WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis

Abrogating G2/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma

(2014) Paola Indovina et al.   CANCER BIOLOGY & THERAPY

A Wee1 checkpoint inhibits anaphase onset

(2013) Noel Lianga et al.   JOURNAL OF CELL BIOLOGY

Mouse models of BRCA1 and their application to breast cancer research

(2012) Jennifer Dine et al.   CANCER AND METASTASIS REVIEWS

Analysis of BRCA1 Variants in Double-Strand Break Repair by Homologous Recombination and Single-Strand Annealing

(2012) William I. Towler et al.   HUMAN MUTATION

Physiological and Oncogenic Aurora-A Pathway

(2012) Toshiaki SAEKI et al.   International Journal of Biological Sciences

MMTV-Cre transgenes can adversely affect lactation: Considerations for conditional gene deletion in mammary tissue

(2011) Gertraud W. Robinson et al.   ANALYTICAL BIOCHEMISTRY

WEE1 inhibition sensitizes osteosarcoma to radiotherapy

(2011) Jantine PosthumaDeBoer et al.   BMC CANCER

SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

(2011) Hyun-Seok Kim et al.   CANCER CELL

MK-1775, a Potent Wee1 Inhibitor, Synergizes with Gemcitabine to Achieve Tumor Regressions, Selectively in p53-Deficient Pancreatic Cancer Xenografts

(2011) N. V. Rajeshkumar et al.   CLINICAL CANCER RESEARCH

Distinct Cdk1 Requirements during Single-Strand Annealing, Noncrossover, and Crossover Recombination

(2011) Camilla Trovesi et al.   PLoS Genetics

MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil

(2010) Hiroshi Hirai et al.   CANCER BIOLOGY & THERAPY

In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma

(2010) Shahryar E. Mir et al.   CANCER CELL

Polo-like kinase 1 (Plk1) in non-melanoma skin cancers

(2010) Travis Schmit et al.   CELL CYCLE

Cdc25 Phosphatases Are Required for Timely Assembly of CDK1-Cyclin B at the G2/M Transition

(2010) Oleg Timofeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

(2009) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

The APC/C: A Smörgåsbord for Proteolysis

(2009) Jonathon Pines   MOLECULAR CELL

Integrated Functional, Gene Expression and Genomic Analysis for the Identification of Cancer Targets

(2009) Elizabeth Iorns et al.   PLoS One

The function of APC/CCdh1 in cell cycle and beyond

(2009) Min Li et al.   Cell Division

G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer

(2008) N Bucher et al.   BRITISH JOURNAL OF CANCER

Genomic stability and tumour suppression by the APC/C cofactor Cdh1

(2008) Irene García-Higuera et al.   NATURE CELL BIOLOGY