The crucial role of ZEB2: From development to epithelial-to-mesenchymal transition and cancer complexity

miR-200c inhibits TGF-β-induced-EMT to restore trastuzumab sensitivity by targeting ZEB1 and ZEB2 in gastric cancer

(2018) Xinliang Zhou et al.   CANCER GENE THERAPY

A p53/miR-30a/ZEB2 axis controls triple negative breast cancer aggressiveness

(2018) Alessandra di Gennaro et al.   CELL DEATH AND DIFFERENTIATION

Transcriptional Regulator ZEB2 Is Essential for Bergmann Glia Development

(2018) Li He et al.   JOURNAL OF NEUROSCIENCE

EMT: Mechanisms and therapeutic implications

(2018) Mohini Singh et al.   PHARMACOLOGY & THERAPEUTICS

Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency

(2018) Bruno Bernardes de Jesus et al.   Nature Communications

Novel Epigenetic Controlling of Hypoxia Pathway Related to Overexpression and Promoter Hypomethylation of TET1 and TET2 in RPE Cells

(2017) Mohammad Reza Alivand et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MicroRNA-192 regulates hypertrophic scar fibrosis by targeting SIP1

(2017) Yan Li et al.   JOURNAL OF MOLECULAR HISTOLOGY

The role of epithelial-mesenchymal transition drivers ZEB1 and ZEB2 in mediating docetaxel-resistant prostate cancer

(2017) Karen Hanrahan et al.   Molecular Oncology

Short stretches of rare codons regulate translation of the transcription factor ZEB2 in cancer cells

(2017) W R Wan Makhtar et al.   ONCOGENE

Downregulation of miR-218 contributes to epithelial–mesenchymal transition and tumor metastasis in lung cancer by targeting Slug/ZEB2 signaling

(2017) Z-M Shi et al.   ONCOGENE

MicroRNA-200c regulates cisplatin resistance by targeting ZEB2 in human gastric cancer cells

(2017) Tao Jiang et al.   ONCOLOGY REPORTS

Long Noncoding RNA-1604 Orchestrates Neural Differentiation through the miR-200c/ZEB Axis

(2017) Rong Weng et al.   STEM CELLS

MiR-204/ZEB2 axis functions as key mediator for MALAT1-induced epithelial–mesenchymal transition in breast cancer

(2017) Yuzhou Wang et al.   TUMOR BIOLOGY

Downregulation of long noncoding RNA TUG1 inhibits proliferation and induces apoptosis through the TUG1/miR-142/ZEB2 axis in bladder cancer cells

(2017) Qian Liu et al.   OncoTargets and Therapy

The putative tumor suppressor microRNA-30a-5p modulates clear cell renal cell carcinoma aggressiveness through repression of ZEB2

(2017) Zhenhua Chen et al.   Cell Death & Disease

Cooperation between ZEB2 and Sp1 promotes cancer cell survival and angiogenesis during metastasis through induction of survivin and VEGF

(2017) Dongjoon Ko et al.   Oncotarget

Direct interaction between miR-203 and ZEB2 suppresses epithelial–mesenchymal transition signaling and reduces lung adenocarcinoma chemoresistance

(2016) Xunhuang Duan et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

The role of microRNAs in colorectal cancer

(2016) Ali Mohammadi et al.   BIOMEDICINE & PHARMACOTHERAPY

The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling

(2016) Jin Li et al.   BLOOD

The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia

(2016) Hubo Li et al.   BLOOD

Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals

(2016) Yotam Menuchin-Lasowski et al.   DEVELOPMENT

The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2

(2016) Charlotte L. Scott et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Zeb2 recruits HDAC–NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination

(2016) Lai Man Natalie Wu et al.   NATURE NEUROSCIENCE

Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate

(2016) Xiaodi Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells

(2016) Agata Stryjewska et al.   STEM CELLS

miR-154 inhibits migration and invasion of human non-small cell lung cancer by targeting ZEB2

(2016) XINGYU LIN et al.   Oncology Letters

microRNA-145 modulates epithelial-mesenchymal transition and suppresses proliferation, migration and invasion by targeting SIP1 in human cervical cancer cells

(2016) Anusha Sathyanarayanan et al.   CELLULAR ONCOLOGY

A directly negative interaction of miR-203 and ZEB2 modulates tumor stemness and chemotherapy resistance in nasopharyngeal carcinoma

(2016) Qingping Jiang et al.   Oncotarget

FOXO1 inhibits the invasion and metastasis of hepatocellular carcinoma by reversing ZEB2-induced epithelial-mesenchymal transition

(2016) Tianxiu Dong et al.   Oncotarget

DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis

(2016) Eunsohl Lee et al.   NEOPLASIA

Genotypes of cancer stem cells characterized by epithelial-to-mesenchymal transition and proliferation related functions

(2016) Chueh-Lin Hsu et al.   Scientific Reports

miR-200 family controls late steps of postnatal forebrain neurogenesis via Zeb2 inhibition

(2016) Christophe Beclin et al.   Scientific Reports

miR-590-3p suppresses cancer cell migration, invasion and epithelial–mesenchymal transition in glioblastoma multiforme by targeting ZEB1 and ZEB2

(2015) Hengyuan Pang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-139-5p inhibits epithelial–mesenchymal transition, migration and invasion of hepatocellular carcinoma cells by targeting ZEB1 and ZEB2

(2015) Gongcai Qiu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-138 Regulates Metastatic Potential of Bladder Cancer Through ZEB2

(2015) De-Kang Sun et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The RAF-MEK-ERK pathway: targeting ERK to overcome obstacles to effective cancer therapy

(2015) Zutao Yu et al.   Future Medicinal Chemistry

ZEB2/SIP1 as novel prognostic indicator in eyelid sebaceous gland carcinoma

(2015) Mansi Bhardwaj et al.   HUMAN PATHOLOGY

MicroRNA-200b inhibits the growth and metastasis of glioma cells via targeting ZEB2

(2015) JIAN LI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection

(2015) Claudia X. Dominguez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection

(2015) Mary J. van Helden et al.   JOURNAL OF EXPERIMENTAL MEDICINE

miR-154 targeting ZEB2 in hepatocellular carcinoma functions as a potential tumor suppressor

(2015) Xiaoli Pang et al.   ONCOLOGY REPORTS

MicroRNA-153 functions as a tumor suppressor by targeting SET7 and ZEB2 in ovarian cancer cells

(2015) JUN ZHOU et al.   ONCOLOGY REPORTS

Zeb2: A multifunctional regulator of nervous system development

(2015) Shane V. Hegarty et al.   PROGRESS IN NEUROBIOLOGY

The role of the transcription factor Ets1 in carcinoma

(2015) Jürgen Dittmer   SEMINARS IN CANCER BIOLOGY

miR-215 functions as a tumor suppressor and directly targets ZEB2 in human non-small cell lung cancer

(2015) YAN HOU et al.   Oncology Letters

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

(2015) Steven Goossens et al.   Nature Communications

MiR-338-3p inhibits epithelial-mesenchymal transition in gastric cancer cells by targeting ZEB2 and MACC1/Met/Akt signaling

(2015) Na Huang et al.   Oncotarget

Double-negative feedback loop between ZEB2 and miR-145 regulates epithelial-mesenchymal transition and stem cell properties in prostate cancer cells

(2014) Dong Ren et al.   CELL AND TISSUE RESEARCH

Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression

(2014) G Denecker et al.   CELL DEATH AND DIFFERENTIATION

Fra-1/AP-1 induces EMT in mammary epithelial cells by modulating Zeb1/2 and TGFβ expression

(2014) L Bakiri et al.   CELL DEATH AND DIFFERENTIATION

NF-κB pathways in hematological malignancies

(2014) Chiara Gasparini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Zinc finger E-box-binding homeobox 2 (ZEB2) regulated by miR-200b contributes to multi-drug resistance of small cell lung cancer

(2014) Shun Fang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

miR-200c modulates ovarian cancer cell metastasis potential by targeting zinc finger E-box-binding homeobox 2 (ZEB2) expression

(2014) Yan-ming Lu et al.   MEDICAL ONCOLOGY

MicroRNA-335 inhibits invasion and metastasis of colorectal cancer by targeting ZEB2

(2014) ZhiFeng Sun et al.   MEDICAL ONCOLOGY

Honokiol Suppresses Renal Cancer Cells’ Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling

(2014) Weidong Li et al.   MOLECULES AND CELLS

Oncogenic roles of EMT-inducing transcription factors

(2014) Alain Puisieux et al.   NATURE CELL BIOLOGY

miR-101 suppresses the epithelial-to-mesenchymal transition by targeting ZEB1 and ZEB2 in ovarian carcinoma

(2014) FEI GUO et al.   ONCOLOGY REPORTS

MiR-141 Suppresses the Migration and Invasion of HCC Cells by Targeting Tiam1

(2014) Ying Liu et al.   PLoS One

MiR-132 Suppresses the Migration and Invasion of Lung Cancer Cells via Targeting the EMT Regulator ZEB2

(2014) Jiacong You et al.   PLoS One

miR-141 targets ZEB2 to suppress HCC progression

(2014) Shi-Min Wu et al.   TUMOR BIOLOGY

miR-132 inhibits colorectal cancer invasion and metastasisviadirectly targeting ZEB2

(2014) Yong-Bin Zheng   WORLD JOURNAL OF GASTROENTEROLOGY

miRNA-205 Is a Candidate Tumor Suppressor that Targets ZEB2 in Renal Cell Carcinoma

(2014) Zhi Chen et al.   Oncology Research and Treatment

CD8 + DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3

(2013) C. Seillet et al.   BLOOD

A Switch in the Expression of Embryonic EMT-Inducers Drives the Development of Malignant Melanoma

(2013) Julie Caramel et al.   CANCER CELL

MiR-200, a new star miRNA in human cancer

(2013) Xiangling Feng et al.   CANCER LETTERS

ZEB2 zinc-finger missense mutations lead to hypomorphic alleles and a mild Mowat–Wilson syndrome

(2013) Jamal Ghoumid et al.   HUMAN MOLECULAR GENETICS

The Ski-Zeb2-Meox2 pathway provides a novel mechanism for regulation of the cardiac myofibroblast phenotype

(2013) R. H. Cunnington et al.   JOURNAL OF CELL SCIENCE

Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development

(2013) Abby L. Manthey et al.   MECHANISMS OF DEVELOPMENT

Four Amino Acids within a Tandem QxVx Repeat in a Predicted Extended α-Helix of the Smad-Binding Domain of Sip1 Are Necessary for Binding to Activated Smad Proteins

(2013) Andrea Conidi et al.   PLoS One

MicroRNA-200b Regulates Cell Proliferation, Invasion, and Migration by Directly Targeting ZEB2 in Gastric Carcinoma

(2012) Junji Kurashige et al.   ANNALS OF SURGICAL ONCOLOGY

EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer

(2012) Alexandria M Haslehurst et al.   BMC CANCER

EMT and MET in Metastasis: Where Are the Cancer Stem Cells?

(2012) Thomas Brabletz   CANCER CELL

Evolutionary functional analysis and molecular regulation of the ZEB transcription factors

(2012) Alexander Gheldof et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness

(2012) Ester Sánchez-Tilló et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A novel long-range enhancer regulates postnatal expression of Zeb2: implications for Mowat-Wilson syndrome phenotypes

(2012) M. M. El-Kasti et al.   HUMAN MOLECULAR GENETICS

Dual-Mode Modulation of Smad Signaling by Smad-Interacting Protein Sip1 Is Required for Myelination in the Central Nervous System

(2012) Qinjie Weng et al.   NEURON

Epithelial–mesenchymal transition transcription factor ZEB1/ZEB2 co-expression predicts poor prognosis and maintains tumor-initiating properties in head and neck cancer

(2012) Pen-Yuan Chu et al.   ORAL ONCOLOGY

ZEB2 Mediates Multiple Pathways Regulating Cell Proliferation, Migration, Invasion, and Apoptosis in Glioma

(2012) Songtao Qi et al.   PLoS One

In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma

(2011) Florian A. Karreth et al.   CELL

ZEB proteins link cell motility with cell cycle control and cell survival in cancer

(2011) Gareth Browne et al.   CELL CYCLE

Evolutionary crossroads in developmental biology: the tunicates

(2011) P. Lemaire   DEVELOPMENT

MicroRNA-200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E-cadherin repressor ZEB2

(2011) Qiuhua Wu et al.   GYNECOLOGIC ONCOLOGY

Functional Cooperation between Snail1 and Twist in the Regulation ofZEB1Expression during Epithelial to Mesenchymal Transition

(2011) Natàlia Dave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

(2011) Taewan Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability

(2011) Monika Jeub et al.   PAIN

Glutathione transferases and development of new principles to overcome drug resistance

(2010) Andrea Sau et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

NFκB inhibitors induce cell death in glioblastomas

(2010) Alfeu Zanotto-Filho et al.   BIOCHEMICAL PHARMACOLOGY

SIP1 Mediates Cell-Fate Decisions between Neuroectoderm and Mesendoderm in Human Pluripotent Stem Cells

(2010) Zhenzhi Chng et al.   Cell Stem Cell

The ZEB/miR-200 feedback loop—a motor of cellular plasticity in development and cancer?

(2010) Simone Brabletz et al.   EMBO REPORTS

Focus on Molecules: Smad Interacting Protein 1 (Sip1, ZEB2, ZFHX1B)

(2010) Abby L. Grabitz et al.   EXPERIMENTAL EYE RESEARCH

Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin

(2010) Igor P. Pogribny et al.   INTERNATIONAL JOURNAL OF CANCER

Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer

(2010) Erik D. Wiklund et al.   INTERNATIONAL JOURNAL OF CANCER

miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor

(2010) N. E. Renthal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptation to Oxidative Stress, Chemoresistance, and Cell Survival

(2009) Matteo Landriscina et al.   ANTIOXIDANTS & REDOX SIGNALING

miR-200a-mediated downregulation of ZEB2 and CTNNB1 differentially inhibits nasopharyngeal carcinoma cell growth, migration and invasion

(2009) Hongping Xia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

miR-200 Expression Regulates Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Reverses Resistance to Epidermal Growth Factor Receptor Therapy

(2009) L. Adam et al.   CLINICAL CANCER RESEARCH

MicroRNA-141 Regulates Smad Interacting Protein 1 (SIP1) and Inhibits Migration and Invasion of Colorectal Cancer Cells

(2009) Minghua Hu et al.   DIGESTIVE DISEASES AND SCIENCES

Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1α, POU/OCT, and NF-κB

(2009) Katoh   INTERNATIONAL JOURNAL OF ONCOLOGY

Identification of the role of Smad interacting protein 1 (SIP1) in glioma

(2009) Microgene Xia et al.   JOURNAL OF NEURO-ONCOLOGY

Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors

(2009) Eve Seuntjens et al.   NATURE NEUROSCIENCE

SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer

(2009) A. E. Sayan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

(2008) C. P. Bracken et al.   CANCER RESEARCH

TGFβ in Cancer

(2008) Joan Massagué   CELL

A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition

(2008) M. Beltran et al.   GENES & DEVELOPMENT

Atypical Mowat-Wilson patient confirms the importance of the novel association between ZFHX1B/SIP1 and NuRD corepressor complex

(2008) G. Verstappen et al.   HUMAN MOLECULAR GENETICS

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY