Interactions of fatty acids, nonsteroidal anti-inflammatory drugs, and coxibs with the catalytic and allosteric subunits of cyclooxygenases-1 and -2

Differential compensation of two cyclooxygenases in renal homeostasis is independent of prostaglandin-synthetic capacity under basal conditions

(2018) Xinzhi Li et al.   FASEB JOURNAL

Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions

(2017) Xinzhi Li et al.   JOURNAL OF LIPID RESEARCH

Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry

(2016) Michael J. Lucido et al.   BIOCHEMISTRY

Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit

(2016) Liang Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2

(2016) Liang Dong et al.   JOURNAL OF LIPID RESEARCH

Different Fatty Acids Compete with Arachidonic Acid for Binding to the Allosteric or Catalytic Subunits of Cyclooxygenases to Regulate Prostanoid Synthesis

(2015) Liang Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Revised Mechanism for Human Cyclooxygenase-2

(2015) Yi Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

13-Methylarachidonic Acid Is a Positive Allosteric Modulator of Endocannabinoid Oxygenation by Cyclooxygenase

(2015) Shalley N. Kudalkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Action at a Distance

(2015) Anna L. Blobaum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytosolic phospholipase A2: physiological function and role in disease

(2015) Christina C. Leslie   JOURNAL OF LIPID RESEARCH

A Cyclooxygenase-2-dependent Prostaglandin E2Biosynthetic System in the Golgi Apparatus

(2014) Chong Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pre-existent Asymmetry in the Human Cyclooxygenase-2 Sequence Homodimer

(2013) Liang Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Investigating Substrate Promiscuity in Cyclooxygenase-2

(2012) Alex J. Vecchio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human cyclooxygenase-1 activity and its responses to COX inhibitors are allosterically regulated by nonsubstrate fatty acids

(2012) Hechang Zou et al.   JOURNAL OF LIPID RESEARCH

Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis

(2011) William L. Smith et al.   CHEMICAL REVIEWS

Endocannabinoid Oxygenation by Cyclooxygenases, Lipoxygenases, and Cytochromes P450: Cross-Talk between the Eicosanoid and Endocannabinoid Signaling Pathways

(2011) Carol A. Rouzer et al.   CHEMICAL REVIEWS

Human Cyclooxygenase-2 Is a Sequence Homodimer That Functions as a Conformational Heterodimer

(2011) Liang Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structural Basis of Endocannabinoid Oxygenation by Cyclooxygenase-2

(2011) Alex J. Vecchio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2

(2011) Kelsey C Duggan et al.   Nature Chemical Biology

Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers,

(2010) Ranjinder S. Sidhu et al.   BIOCHEMISTRY

Localization and function of cytosolic phospholipase A2α at the Golgi

(2010) Christina C. Leslie et al.   BIOCHIMIE

Structural Basis of Fatty Acid Substrate Binding to Cyclooxygenase-2

(2010) Alex J. Vecchio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis for Cyclooxygenase Inhibition by the Non-steroidal Anti-inflammatory Drug Naproxen

(2010) Kelsey C. Duggan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asymmetric Acetylation of the Cyclooxygenase-2 Homodimer by Aspirin and Its Effects on the Oxygenation of Arachidonic, Eicosapentaenoic, and Docosahexaenoic Acids

(2010) N. P. Sharma et al.   MOLECULAR PHARMACOLOGY

Prostaglandin H synthase: Resolved and unresolved mechanistic issues

(2009) Ah-Lim Tsai et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Differential Sensitivity and Mechanism of Inhibition of COX-2 Oxygenation of Arachidonic Acid and 2-Arachidonoylglycerol by Ibuprofen and Mefenamic Acid

(2009) Jeffery J. Prusakiewicz et al.   BIOCHEMISTRY

Cyclooxygenase Allosterism, Fatty Acid-mediated Cross-talk between Monomers of Cyclooxygenase Homodimers

(2009) Chong Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1

(2009) G. Rimon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Bodies Are Reservoirs of Cyclooxygenase-2 and Sites of Prostaglandin-E2 Synthesis in Colon Cancer Cells

(2008) M. T. Accioly et al.   CANCER RESEARCH

Non-redundant Functions of Cyclooxygenases: Oxygenation of Endocannabinoids

(2008) Carol A. Rouzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY