Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling

Membrane tethering of APP c-terminal fragments is a prerequisite for T668 phosphorylation preventing nuclear sphere generation

(2016) Hassan Bukhari et al.   CELLULAR SIGNALLING

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Dual-specificity phosphatase 26 (DUSP26) stimulates Aβ42 generation by promoting amyloid precursor protein axonal transport during hypoxia

(2016) Sunmin Jung et al.   JOURNAL OF NEUROCHEMISTRY

Masitinib for the treatment of mild to moderate Alzheimer’s disease

(2015) Jaume Folch et al.   Expert Review of Neurotherapeutics

Masitinib for the treatment of mild to moderate Alzheimer’s disease

(2015) Jaume Folch et al.   Expert Review of Neurotherapeutics

The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cells

(2014) Mallory Gough et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention

(2014) Sam Butterworth et al.   Future Medicinal Chemistry

The Neuroprotective Effect of Klotho is Mediated via Regulation of Members of the Redox System

(2014) Ella Zeldich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Amyloid Precursor Protein Represses Expression of Acetylcholinesterase in Neuronal Cell Lines

(2013) David A. Hicks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Antiaging Protein Klotho Enhances Oligodendrocyte Maturation and Myelination of the CNS

(2013) C.-D. Chen et al.   JOURNAL OF NEUROSCIENCE

Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer’s Disease Pathology

(2013) Fanggeng Zou et al.   PLoS One

Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance

(2012) Carmela Matrone et al.   AGING CELL

Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization

(2012) Ling-Ling Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic targeting of c-KIT in cancer

(2012) Leonie K Ashman et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Identification of potent small-molecule inhibitors of STAT3 with anti-inflammatory properties in RAW 264.7 macrophages

(2012) Hemachander Capiralla et al.   FEBS Journal

Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop

(2012) Nicola Aceto et al.   NATURE MEDICINE

Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical Implications

(2012) Johan Lennartsson et al.   PHYSIOLOGICAL REVIEWS

Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization

(2012) James E. Dowling et al.   ACS Medicinal Chemistry Letters

Susceptibility to diet-induced obesity and glucose intolerance in the APP SWE/PSEN1 A246E mouse model of Alzheimer’s disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein

(2011) N. Mody et al.   DIABETOLOGIA

Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4

(2011) Mariana Cooke et al.   JOURNAL OF LIPID RESEARCH

Preclinical Development of the Novel Chk1 Inhibitor SCH900776 in Combination with DNA-Damaging Agents and Antimetabolites

(2011) R. Montano et al.   MOLECULAR CANCER THERAPEUTICS

New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck

(2010) Nina Gommermann et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach—Part 1

(2010) Michael P. Dwyer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Illuminating Insights into Firefly Luciferase and Other Bioluminescent Reporters Used in Chemical Biology

(2010) Natasha Thorne et al.   CHEMISTRY & BIOLOGY

Sorting of the Alzheimer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex

(2010) Patricia V. Burgos et al.   DEVELOPMENTAL CELL

A -Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP61

(2010) P. Kurup et al.   JOURNAL OF NEUROSCIENCE

Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model

(2010) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced Dimerization of the Amyloid Precursor Protein Leads to Decreased Amyloid-β Protein Production

(2009) Simone Eggert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains

(2009) Robert Tamayev et al.   Molecular Neurodegeneration

Phosphorylation of amyloid precursor protein (APP) at Tyr687 regulates APP processing by α- and γ-secretase

(2008) Keita Takahashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Amyloid β-Protein Precursor by Phosphorylation and Protein Interactions

(2008) Toshiharu Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gab2 Is Involved in Differential Phosphoinositide 3-Kinase Signaling by Two Splice Forms of c-Kit

(2008) Jianmin Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

7-Aminopyrazolo[1,5-a]pyrimidines as Potent Multitargeted Receptor Tyrosine Kinase Inhibitors

(2008) Robin R. Frey et al.   JOURNAL OF MEDICINAL CHEMISTRY

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking

(2008) K. Hellmuth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA