Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention

Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects

(2015) Taolin Yi et al.   Oncotarget

Targeting Protein-Tyrosine Phosphatases in Breast Cancer

(2015)   Oncotarget

Targeting SHP2 phosphatase in Myeloproliferative Neoplasms

(2015) Raghuveer Singh Mali et al.   Oncotarget

Targeting the disordered C terminus of PTP1B with an allosteric inhibitor

(2014) Navasona Krishnan et al.   Nature Chemical Biology

Structural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11)

(2014) Wei Qiu et al.   BMC STRUCTURAL BIOLOGY

Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma

(2013) Jie Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

(2013) A. Mazharian et al.   BLOOD

Blocking initial infiltration of pioneer CD8+T-cells into the CNS via inhibition of SHP-2 ameliorates experimental autoimmune encephalomyelitis in mice

(2013) Qiong Luo et al.   BRITISH JOURNAL OF PHARMACOLOGY

New Approaches to Prevent LEOPARD Syndrome-associated Cardiac Hypertrophy by Specifically Targeting Shp2-dependent Signaling

(2013) Christine Schramm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations

(2013) Zhi-Hong Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Disruption ofShp2in Chondrocytes Leads to Metachondromatosis With Multiple Cartilaginous Protrusions

(2013) Harry KW Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases

(2013) Yantao He et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Cryptotanshinone as an Inhibitor of Oncogenic Protein Tyrosine Phosphatase SHP2 (PTPN11)

(2013) Wei Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Epithelial Tyrosine Phosphatase SHP-2 Protects against Intestinal Inflammation in Mice

(2013) G. Coulombe et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting Protein Tyrosine Phosphatase SHP2 for the Treatment of PTPN11-Associated Malignancies

(2013) B. Yu et al.   MOLECULAR CANCER THERAPEUTICS

Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling

(2013) Wentian Yang et al.   NATURE

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

(2013) David T W Jones et al.   NATURE GENETICS

The genetic landscape of high-risk neuroblastoma

(2013) Trevor J Pugh et al.   NATURE GENETICS

Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase

(2013) K Miura et al.   ONCOGENE

Loss of SHP-2 activity in CD4+ T cells promotes melanoma progression and metastasis

(2013) Tao Zhang et al.   Scientific Reports

Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT

(2012) R. S. Mali et al.   BLOOD

Tautomycetin Induces Apoptosis by Inactivating Akt Through a PP1-Independent Signaling Pathway in Human Breast Cancer Cells

(2012) Mingshan Niu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Differential Effects of Tautomycetin and Its Derivatives on Protein Phosphatase Inhibition, Immunosuppressive Function and Antitumor Activity

(2012) Mingshan Niu et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

SH2 Domain-Containing Phosphatase 2 Is a Critical Regulator of Connective Tissue Mast Cell Survival and Homeostasis in Mice

(2012) N. Sharma et al.   MOLECULAR AND CELLULAR BIOLOGY

Shp2 Controls Female Body Weight and Energy Balance by Integrating Leptin and Estrogen Signals

(2012) Z. He et al.   MOLECULAR AND CELLULAR BIOLOGY

Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop

(2012) Nicola Aceto et al.   NATURE MEDICINE

Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis

(2012) Shuangwei Li et al.   Frontiers of Medicine

Checks and balances: Interplay of RTKs and PTPs in cancer progression

(2011) Sarita K. Sastry et al.   BIOCHEMICAL PHARMACOLOGY

The use of estramustine phosphate in the modern management of advanced prostate cancer

(2011) Vincent Ravery et al.   BJU INTERNATIONAL

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

(2011) Emilie A. Bard-Chapeau et al.   CANCER CELL

SHP2 Is a Target of the Immunosuppressant Tautomycetin

(2011) Sijiu Liu et al.   CHEMISTRY & BIOLOGY

Loss-of-Function Mutations in PTPN11 Cause Metachondromatosis, but Not Ollier Disease or Maffucci Syndrome

(2011) Margot E. Bowen et al.   PLoS Genetics

Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112

(2010) Liwei Chen et al.   BIOCHEMICAL PHARMACOLOGY

Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs

(2010) Latanya M. Scott et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phosphatase-Dependent and -Independent Functions of Shp2 in Neural Crest Cells Underlie LEOPARD Syndrome Pathogenesis

(2010) Rodney A. Stewart et al.   DEVELOPMENTAL CELL

Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations

(2010) T. J. Bauler et al.   Disease Models & Mechanisms

Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development

(2010) Alastair J Barr   Future Medicinal Chemistry

Novel SHP-1 Inhibitors Tyrosine Phosphatase Inhibitor-1 and Analogs with Preclinical Anti-Tumor Activities as Tolerated Oral Agents

(2010) S. Kundu et al.   JOURNAL OF IMMUNOLOGY

Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)

(2010) Xian Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Whole-Genome Sequencing of a Single Proband Together with Linkage Analysis Identifies a Mendelian Disease Gene

(2010) Nara L. M. Sobreira et al.   PLoS Genetics

NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26)

(2009) Mina Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein tyrosine phosphatase SHP-2: A proto-oncogene product that promotes Ras activation

(2009) Takashi Matozaki et al.   CANCER SCIENCE

Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome

(2009) Alastair J. Barr et al.   CELL

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

Tyrosine phosphorylation: thirty years and counting

(2009) Tony Hunter   CURRENT OPINION IN CELL BIOLOGY

The therapeutic potential of phosphatase inhibitors

(2009) Viktor V Vintonyak et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

GLEPP1/Protein-tyrosine Phosphatase ϕ Inhibitors Block Chemotaxisin Vitroandin Vivoand Improve Murine Ulcerative Colitis

(2009) Rosanna Pescini Gobert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent Advances in the Discovery of Competitive Protein Tyrosine Phosphatase 1B Inhibitors for the Treatment of Diabetes, Obesity, and Cancer

(2009) Andrew P. Combs   JOURNAL OF MEDICINAL CHEMISTRY

Pentavalent Antimonials: New Perspectives for Old Drugs

(2009) Frédéric Frézard et al.   MOLECULES

Selectivity and therapeutic inhibition of kinases: to be or not to be?

(2009) Kamran Ghoreschi et al.   NATURE IMMUNOLOGY

Focal amplification and oncogene dependency of GAB2 in breast cancer

(2009) M Bocanegra et al.   ONCOGENE

Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic  -cells

(2009) S. S. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tyrosine phosphatase Shp2 (PTPN11) in cancer

(2008) Gordon Chan et al.   CANCER AND METASTASIS REVIEWS

Deletion of Ptpn11 (Shp2) in Cardiomyocytes Causes Dilated Cardiomyopathy via Effects on the Extracellular Signal–Regulated Kinase/Mitogen-Activated Protein Kinase and RhoA Signaling Pathways

(2008) Maria I. Kontaridis et al.   CIRCULATION

SHP2 is up-regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis

(2008) X Zhou et al.   HISTOPATHOLOGY

2-Thiazolylimino/Heteroarylimino-5-arylidene-4-thiazolidinones as New Agents with SHP-2 Inhibitory Action

(2008) A. Geronikaki et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Small Molecular Weight Inhibitors of Src Homology 2 Domain-Containing Tyrosine Phosphatase 2 (SHP-2) via in Silico Database Screening Combined with Experimental Assay

(2008) Wen-Mei Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibitors of Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (Shp2) Based on Oxindole Scaffolds

(2008) Harshani R. Lawrence et al.   JOURNAL OF MEDICINAL CHEMISTRY

Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors

(2008) D Miyamoto et al.   ONCOGENE

Leopard syndrome

(2008) Anna Sarkozy et al.   Orphanet Journal of Rare Diseases

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking

(2008) K. Hellmuth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA