Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention
Authors
Keywords
-
Journal
Future Medicinal Chemistry
Volume 6, Issue 12, Pages 1423-1437
Publisher
Future Science, LTD
Online
2014-10-20
DOI
10.4155/fmc.14.88
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects
- (2015) Taolin Yi et al. Oncotarget
- Targeting Protein-Tyrosine Phosphatases in Breast Cancer
- (2015) Oncotarget
- Targeting SHP2 phosphatase in Myeloproliferative Neoplasms
- (2015) Raghuveer Singh Mali et al. Oncotarget
- Targeting the disordered C terminus of PTP1B with an allosteric inhibitor
- (2014) Navasona Krishnan et al. Nature Chemical Biology
- Structural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11)
- (2014) Wei Qiu et al. BMC STRUCTURAL BIOLOGY
- Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma
- (2013) Jie Xu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function
- (2013) A. Mazharian et al. BLOOD
- Blocking initial infiltration of pioneer CD8+T-cells into the CNS via inhibition of SHP-2 ameliorates experimental autoimmune encephalomyelitis in mice
- (2013) Qiong Luo et al. BRITISH JOURNAL OF PHARMACOLOGY
- New Approaches to Prevent LEOPARD Syndrome-associated Cardiac Hypertrophy by Specifically Targeting Shp2-dependent Signaling
- (2013) Christine Schramm et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations
- (2013) Zhi-Hong Yu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeted Disruption ofShp2in Chondrocytes Leads to Metachondromatosis With Multiple Cartilaginous Protrusions
- (2013) Harry KW Kim et al. JOURNAL OF BONE AND MINERAL RESEARCH
- A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases
- (2013) Yantao He et al. JOURNAL OF MEDICINAL CHEMISTRY
- Identification of Cryptotanshinone as an Inhibitor of Oncogenic Protein Tyrosine Phosphatase SHP2 (PTPN11)
- (2013) Wei Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Epithelial Tyrosine Phosphatase SHP-2 Protects against Intestinal Inflammation in Mice
- (2013) G. Coulombe et al. MOLECULAR AND CELLULAR BIOLOGY
- Targeting Protein Tyrosine Phosphatase SHP2 for the Treatment of PTPN11-Associated Malignancies
- (2013) B. Yu et al. MOLECULAR CANCER THERAPEUTICS
- Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling
- (2013) Wentian Yang et al. NATURE
- Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
- (2013) David T W Jones et al. NATURE GENETICS
- The genetic landscape of high-risk neuroblastoma
- (2013) Trevor J Pugh et al. NATURE GENETICS
- Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase
- (2013) K Miura et al. ONCOGENE
- Loss of SHP-2 activity in CD4+ T cells promotes melanoma progression and metastasis
- (2013) Tao Zhang et al. Scientific Reports
- Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT
- (2012) R. S. Mali et al. BLOOD
- Tautomycetin Induces Apoptosis by Inactivating Akt Through a PP1-Independent Signaling Pathway in Human Breast Cancer Cells
- (2012) Mingshan Niu et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Differential Effects of Tautomycetin and Its Derivatives on Protein Phosphatase Inhibition, Immunosuppressive Function and Antitumor Activity
- (2012) Mingshan Niu et al. KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- SH2 Domain-Containing Phosphatase 2 Is a Critical Regulator of Connective Tissue Mast Cell Survival and Homeostasis in Mice
- (2012) N. Sharma et al. MOLECULAR AND CELLULAR BIOLOGY
- Shp2 Controls Female Body Weight and Energy Balance by Integrating Leptin and Estrogen Signals
- (2012) Z. He et al. MOLECULAR AND CELLULAR BIOLOGY
- Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop
- (2012) Nicola Aceto et al. NATURE MEDICINE
- Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis
- (2012) Shuangwei Li et al. Frontiers of Medicine
- Checks and balances: Interplay of RTKs and PTPs in cancer progression
- (2011) Sarita K. Sastry et al. BIOCHEMICAL PHARMACOLOGY
- The use of estramustine phosphate in the modern management of advanced prostate cancer
- (2011) Vincent Ravery et al. BJU INTERNATIONAL
- Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis
- (2011) Emilie A. Bard-Chapeau et al. CANCER CELL
- SHP2 Is a Target of the Immunosuppressant Tautomycetin
- (2011) Sijiu Liu et al. CHEMISTRY & BIOLOGY
- Loss-of-Function Mutations in PTPN11 Cause Metachondromatosis, but Not Ollier Disease or Maffucci Syndrome
- (2011) Margot E. Bowen et al. PLoS Genetics
- Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112
- (2010) Liwei Chen et al. BIOCHEMICAL PHARMACOLOGY
- Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs
- (2010) Latanya M. Scott et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Phosphatase-Dependent and -Independent Functions of Shp2 in Neural Crest Cells Underlie LEOPARD Syndrome Pathogenesis
- (2010) Rodney A. Stewart et al. DEVELOPMENTAL CELL
- Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations
- (2010) T. J. Bauler et al. Disease Models & Mechanisms
- Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development
- (2010) Alastair J Barr Future Medicinal Chemistry
- Novel SHP-1 Inhibitors Tyrosine Phosphatase Inhibitor-1 and Analogs with Preclinical Anti-Tumor Activities as Tolerated Oral Agents
- (2010) S. Kundu et al. JOURNAL OF IMMUNOLOGY
- Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)
- (2010) Xian Zhang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Whole-Genome Sequencing of a Single Proband Together with Linkage Analysis Identifies a Mendelian Disease Gene
- (2010) Nara L. M. Sobreira et al. PLoS Genetics
- NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26)
- (2009) Mina Song et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Protein tyrosine phosphatase SHP-2: A proto-oncogene product that promotes Ras activation
- (2009) Takashi Matozaki et al. CANCER SCIENCE
- Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome
- (2009) Alastair J. Barr et al. CELL
- Serine/Threonine Phosphatases: Mechanism through Structure
- (2009) Yigong Shi CELL
- Tyrosine phosphorylation: thirty years and counting
- (2009) Tony Hunter CURRENT OPINION IN CELL BIOLOGY
- The therapeutic potential of phosphatase inhibitors
- (2009) Viktor V Vintonyak et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- GLEPP1/Protein-tyrosine Phosphatase ϕ Inhibitors Block Chemotaxisin Vitroandin Vivoand Improve Murine Ulcerative Colitis
- (2009) Rosanna Pescini Gobert et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Recent Advances in the Discovery of Competitive Protein Tyrosine Phosphatase 1B Inhibitors for the Treatment of Diabetes, Obesity, and Cancer
- (2009) Andrew P. Combs JOURNAL OF MEDICINAL CHEMISTRY
- Pentavalent Antimonials: New Perspectives for Old Drugs
- (2009) Frédéric Frézard et al. MOLECULES
- Selectivity and therapeutic inhibition of kinases: to be or not to be?
- (2009) Kamran Ghoreschi et al. NATURE IMMUNOLOGY
- Focal amplification and oncogene dependency of GAB2 in breast cancer
- (2009) M Bocanegra et al. ONCOGENE
- Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic -cells
- (2009) S. S. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The tyrosine phosphatase Shp2 (PTPN11) in cancer
- (2008) Gordon Chan et al. CANCER AND METASTASIS REVIEWS
- Deletion of Ptpn11 (Shp2) in Cardiomyocytes Causes Dilated Cardiomyopathy via Effects on the Extracellular Signal–Regulated Kinase/Mitogen-Activated Protein Kinase and RhoA Signaling Pathways
- (2008) Maria I. Kontaridis et al. CIRCULATION
- SHP2 is up-regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis
- (2008) X Zhou et al. HISTOPATHOLOGY
- 2-Thiazolylimino/Heteroarylimino-5-arylidene-4-thiazolidinones as New Agents with SHP-2 Inhibitory Action
- (2008) A. Geronikaki et al. JOURNAL OF MEDICINAL CHEMISTRY
- Identification of Small Molecular Weight Inhibitors of Src Homology 2 Domain-Containing Tyrosine Phosphatase 2 (SHP-2) via in Silico Database Screening Combined with Experimental Assay
- (2008) Wen-Mei Yu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Inhibitors of Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (Shp2) Based on Oxindole Scaffolds
- (2008) Harshani R. Lawrence et al. JOURNAL OF MEDICINAL CHEMISTRY
- Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors
- (2008) D Miyamoto et al. ONCOGENE
- Leopard syndrome
- (2008) Anna Sarkozy et al. Orphanet Journal of Rare Diseases
- Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking
- (2008) K. Hellmuth et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now