Role of Serotonergic System in the Antidepressant Actions of mGlu2/3 Receptor Antagonists: Similarity to Ketamine

Common Neurotransmission Recruited in ( R , S )-Ketamine and (2 R ,6 R )-Hydroxynorketamine–Induced Sustained Antidepressant-like Effects

(2018) Thu Ha Pham et al.   BIOLOGICAL PSYCHIATRY

Ketamine-Induced Prefrontal Serotonin Release Is Mediated by Cholinergic Neurons in the Pedunculopontine Tegmental Nucleus

(2018) Haruko Kinoshita et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Prefrontal alterations in GABAergic and glutamatergic gene expression in relation to depression and suicide

(2018) J. Zhao et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Mechanisms of ketamine action as an antidepressant

(2018) P Zanos et al.   MOLECULAR PSYCHIATRY

Serotonergic mechanisms involved in antidepressant-like responses evoked by GLT-1 blockade in rat infralimbic cortex

(2018) Júlia Gasull-Camós et al.   NEUROPHARMACOLOGY

5-HT 1A receptor stimulation in the medial prefrontal cortex mediates the antidepressant effects of mGlu2/3 receptor antagonist in mice

(2018) Kenichi Fukumoto et al.   NEUROPHARMACOLOGY

S-Ketamine Mediates Its Acute and Sustained Antidepressant-Like Activity through a 5-HT1B Receptor Dependent Mechanism in a Genetic Rat Model of Depression

(2018) Kristian G. du Jardin et al.   Frontiers in Pharmacology

5-Hydroxytryptamine-Independent Antidepressant Actions of (R)-Ketamine in a Chronic Social Defeat Stress Model

(2017) Kai Zhang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Role of 5-HT1A Receptor Stimulation in the Medial Prefrontal Cortex in the Sustained Antidepressant Effects of Ketamine

(2017) Kenichi Fukumoto et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Assessment of Ketamine Binding of the Serotonin Transporter in Humans with Positron Emission Tomography

(2017) Marie Spies et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Targeting glutamate signalling in depression: progress and prospects

(2017) James W. Murrough et al.   NATURE REVIEWS DRUG DISCOVERY

Ketamine treatment involves medial prefrontal cortex serotonin to induce a rapid antidepressant-like activity in BALB/cJ mice

(2017) T.H. Pham et al.   NEUROPHARMACOLOGY

Preclinical predictors that the orthosteric mGlu2/3 receptor antagonist LY3020371 will not engender ketamine-associated neurotoxic, motor, cognitive, subjective, or abuse-liability-related effects

(2017) JM Witkin et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

mGlu2/3 Receptor Antagonists as Novel Antidepressants

(2017) Shigeyuki Chaki   TRENDS IN PHARMACOLOGICAL SCIENCES

Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs

(2017) Julie L. Engers et al.   ACS Medicinal Chemistry Letters

The role of 5-HT receptors in depression

(2017) Christine N. Yohn et al.   Molecular Brain

Glial GLT-1 blockade in infralimbic cortex as a new strategy to evoke rapid antidepressant-like effects in rats

(2017) J Gasull-Camós et al.   Translational Psychiatry

Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity

(2016) Danielle M. Gerhard et al.   DRUG DISCOVERY TODAY

Glutamate-Based Drug Discovery for Novel Antidepressants

(2016) Agnieszka Pałucha-Poniewiera et al.   Expert Opinion on Drug Discovery

Rapid and Sustained Antidepressant Action of the mGlu2/3 Receptor Antagonist MGS0039 in the Social Defeat Stress Model: Comparison with Ketamine

(2016) Chao Dong et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Lower [3H]LY341495 binding to mGlu2/3 receptors in the anterior cingulate of subjects with major depressive disorder but not bipolar disorder or schizophrenia

(2016) Caitlin E McOmish et al.   JOURNAL OF AFFECTIVE DISORDERS

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

Ketamine up-regulates a cluster of intronic miRNAs within the serotonin receptor 2C gene by inhibiting glycogen synthase kinase-3

(2016) Steven F. Grieco et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression

(2015) D. Jeffrey Newport et al.   AMERICAN JOURNAL OF PSYCHIATRY

Impact of subanesthetic doses of ketamine on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons

(2015) Kareem S El Iskandrani et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The Antidepressant Effects of an mGlu2/3 Receptor Antagonist and Ketamine Require AMPA Receptor Stimulation in the mPFC and Subsequent Activation of the 5-HT Neurons in the DRN

(2015) Kenichi Fukumoto et al.   NEUROPSYCHOPHARMACOLOGY

Optogenetic stimulation of infralimbic PFC reproduces ketamine’s rapid and sustained antidepressant actions

(2015) Manabu Fuchikami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats

(2014) Hiroyuki Koike et al.   BEHAVIOURAL BRAIN RESEARCH

Raphe AMPA receptors and nicotinic acetylcholine receptors mediate ketamine-induced serotonin release in the rat prefrontal cortex

(2014) Naoya Nishitani et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Mind the gap: glucocorticoids modulate hippocampal glutamate tone underlying individual differences in stress susceptibility

(2014) C Nasca et al.   MOLECULAR PSYCHIATRY

Rivastigmine improves hippocampal neurogenesis and depression-like behaviors via 5-HT1A receptor stimulation in olfactory bulbectomized mice

(2014) M.R. Islam et al.   NEUROSCIENCE

Serotonin-1A receptor stimulation mediates effects of a metabotropic glutamate 2/3 receptor antagonist, 2S-2-amino-2-(1S,2S-2-carboxycycloprop-1-yl)-3-(xanth-9-yl)propanoic acid (LY341495), and an N-methyl-D-aspartate receptor antagonist, ketamine, in the novelty-suppressed feeding test

(2014) Kenichi Fukumoto et al.   PSYCHOPHARMACOLOGY

A possible mechanism of the nucleus accumbens and ventral pallidum 5-HT1B receptors underlying the antidepressant action of ketamine: a PET study with macaques

(2014) H Yamanaka et al.   Translational Psychiatry

mGlu2/3 Agonist-Induced Hyperthermia: An In Vivo Assay for Detection of mGlu2/3 Receptor Antagonism and its Relation to Antidepressant-Like Efficacy in Mice

(2013) S.D. Gleason et al.   CNS & Neurological Disorders-Drug Targets

Subanesthetic Doses of Ketamine Transiently Decrease Serotonin Transporter Activity: A PET Study in Conscious Monkeys

(2013) Shigeyuki Yamamoto et al.   NEUROPSYCHOPHARMACOLOGY

Effects of ketamine and LY341495 on the depressive-like behavior of repeated corticosterone-injected rats

(2013) Hiroyuki Koike et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism

(2013) Valentina Gigliucci et al.   PSYCHOPHARMACOLOGY

Role of BDNF/TrkB signaling in antidepressant-like effects of a group II metabotropic glutamate receptor antagonist in animal models of depression

(2012) Hiroyuki Koike et al.   BEHAVIOURAL BRAIN RESEARCH

Presynaptic  4 2 Nicotinic Acetylcholine Receptors Increase Glutamate Release and Serotonin Neuron Excitability in the Dorsal Raphe Nucleus

(2012) J. Garduno et al.   JOURNAL OF NEUROSCIENCE

A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge

(2012) Melissa R. Warden et al.   NATURE

Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice

(2012) Yukio Ago et al.   NEUROPHARMACOLOGY

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

(2011) Nanxin Li et al.   BIOLOGICAL PSYCHIATRY

Functional significance of glycogen synthase kinase-3 regulation by serotonin

(2011) Abigail M. Polter et al.   CELLULAR SIGNALLING

mTOR activation is required for the antidepressant effects of mGluR2/3 blockade

(2011) Jason M. Dwyer et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists

(2011) Hiroyuki Koike et al.   NEUROPHARMACOLOGY

F15599, a highly selective post-synaptic 5-HT1A receptor agonist: in-vivo profile in behavioural models of antidepressant and serotonergic activity

(2010) Marie-Bernadette Assié et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice

(2010) Toshiyuki Kawasaki et al.   NEUROPHARMACOLOGY

On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039

(2010) Agnieszka Pałucha-Poniewiera et al.   PSYCHOPHARMACOLOGY

Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression

(2009) Anteneh M. Feyissa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY