Role of 5-HT1A Receptor Stimulation in the Medial Prefrontal Cortex in the Sustained Antidepressant Effects of Ketamine

Ketamine treatment involves medial prefrontal cortex serotonin to induce a rapid antidepressant-like activity in BALB/cJ mice

(2017) T.H. Pham et al.   NEUROPHARMACOLOGY

Serotonin Signaling through Prefrontal Cortex 5-HT 1A Receptors during Adolescence Can Determine Baseline Mood-Related Behaviors

(2017) Alvaro L. Garcia-Garcia et al.   Cell Reports

Glial GLT-1 blockade in infralimbic cortex as a new strategy to evoke rapid antidepressant-like effects in rats

(2017) J Gasull-Camós et al.   Translational Psychiatry

Serotonin-1A receptor alterations in depression: a meta-analysis of molecular imaging studies

(2016) Ling Wang et al.   BMC Psychiatry

Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity

(2016) Danielle M. Gerhard et al.   DRUG DISCOVERY TODAY

Structural Insights into 5-HT1A/D4 Selectivity of WAY-100635 Analogues: Molecular Modeling, Synthesis, and in Vitro Binding

(2016) Sébastien Dilly et al.   Journal of Chemical Information and Modeling

Rapid and Sustained Reductions in Current Suicidal Ideation Following Repeated Doses of Intravenous Ketamine

(2016) Dawn F. Ionescu et al.   JOURNAL OF CLINICAL PSYCHIATRY

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors

(2016) Raquel Linge et al.   NEUROPHARMACOLOGY

Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression

(2016) Kristian Gaarn du Jardin et al.   PSYCHOPHARMACOLOGY

Does Ketamine Have Anti-Suicidal Properties? Current Status and Future Directions

(2015) Rebecca B. Price et al.   CNS DRUGS

Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor Ligands

(2015) Zdzisław Chilmonczyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of a ventral hippocampus–medial prefrontal cortex pathway is both necessary and sufficient for an antidepressant response to ketamine

(2015) F R Carreno et al.   MOLECULAR PSYCHIATRY

5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response

(2015) Benjamin Adam Samuels et al.   NATURE NEUROSCIENCE

The Antidepressant Effects of an mGlu2/3 Receptor Antagonist and Ketamine Require AMPA Receptor Stimulation in the mPFC and Subsequent Activation of the 5-HT Neurons in the DRN

(2015) Kenichi Fukumoto et al.   NEUROPSYCHOPHARMACOLOGY

Optogenetic stimulation of infralimbic PFC reproduces ketamine’s rapid and sustained antidepressant actions

(2015) Manabu Fuchikami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Raphe AMPA receptors and nicotinic acetylcholine receptors mediate ketamine-induced serotonin release in the rat prefrontal cortex

(2014) Naoya Nishitani et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Rivastigmine improves hippocampal neurogenesis and depression-like behaviors via 5-HT1A receptor stimulation in olfactory bulbectomized mice

(2014) M.R. Islam et al.   NEUROSCIENCE

Serotonin-1A receptor stimulation mediates effects of a metabotropic glutamate 2/3 receptor antagonist, 2S-2-amino-2-(1S,2S-2-carboxycycloprop-1-yl)-3-(xanth-9-yl)propanoic acid (LY341495), and an N-methyl-D-aspartate receptor antagonist, ketamine, in the novelty-suppressed feeding test

(2014) Kenichi Fukumoto et al.   PSYCHOPHARMACOLOGY

Rapid-Acting Glutamatergic Antidepressants: The Path to Ketamine and Beyond

(2013) John H. Krystal et al.   BIOLOGICAL PSYCHIATRY

Subanesthetic Doses of Ketamine Transiently Decrease Serotonin Transporter Activity: A PET Study in Conscious Monkeys

(2013) Shigeyuki Yamamoto et al.   NEUROPSYCHOPHARMACOLOGY

The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor

(2013) Bryan L. Roth et al.   PLoS One

Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism

(2013) Valentina Gigliucci et al.   PSYCHOPHARMACOLOGY

Ketamine for Depression: Where Do We Go from Here?

(2012) Marije aan het Rot et al.   BIOLOGICAL PSYCHIATRY

Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression?

(2012) Rafael A Barreto et al.   BMC NEUROSCIENCE

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

(2012) Ronald S. Duman et al.   TRENDS IN NEUROSCIENCES

Functional significance of glycogen synthase kinase-3 regulation by serotonin

(2011) Abigail M. Polter et al.   CELLULAR SIGNALLING

Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists

(2011) Hiroyuki Koike et al.   NEUROPHARMACOLOGY

F15599, a highly selective post-synaptic 5-HT1A receptor agonist: in-vivo profile in behavioural models of antidepressant and serotonergic activity

(2010) Marie-Bernadette Assié et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder

(2008) Bernadeta Szewczyk et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY