Article
Hematology
Jacob Stauber, John M. Greally, Ulrich Steidl
Summary: This review discusses the role of clonal evolution in hematological malignancies and emphasizes the contribution of the hematopoietic stem cell population in disease progression and relapse. Recent advances and unanswered questions in this field are highlighted.
Review
Oncology
Igor Valentim Barreto, Flavia Melo Cunha de Pinho Pessoa, Caio Bezerra Machado, Laudreisa da Costa Pantoja, Rodrigo Monteiro Ribeiro, Germison Silva Lopes, Maria Elisabete Amaral de Moraes, Manoel Odorico de Moraes Filho, Lucas Eduardo Botelho de Souza, Rommel Mario Rodriguez Burbano, Andre Salim Khayat, Caroline Aquino Moreira-Nunes
Summary: This article describes the characteristics and differences between hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs), as well as the challenges of LSCs treatment and possible alternative approaches.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Tony Marchand, Sandra Pinho
Summary: Acute myeloid leukemia (AML) is a common type of leukemia in adults, with complete remission attainable in young and fit patients through intensive chemotherapy, but with frequent relapse and poor prognosis. Leukemic stem cells (LSCs) at the top of the hierarchy are thought to drive relapse due to their specific mutations and metabolic profile, which make them resistant to chemotherapy, as opposed to healthy hematopoietic stem cells (HSCs).
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Lina Liu, Ana Vujovic, Nandan P. Deshpande, Shashank Sathe, Govardhan Anande, He Tian Tony Chen, Joshua Xu, Mark D. Minden, Gene W. Yeo, Ashwin Unnikrishnan, Kristin J. Hope, Yu Lu
Summary: The splicing factor RBM17 supports leukemic stem cells (LSCs) in acute myeloid leukemia (AML) by avoiding nonsense-mediated decay of pro-leukemic factors such as the translation initiation factor EIF4A2. Targeting RBM17 and its downstream NMD-sensitive splicing substrates may provide a therapeutic strategy for AML treatment.
NATURE COMMUNICATIONS
(2022)
Review
Pathology
Mohsen Karami Fath, Setareh Garousi, Mehran Mottahedi, Nasim Ghasemzadeh, Kiana Salmani, Fatemeh Olfati, Miad Beit Saeed, Sina Sotoudeh, Ghasem Barati
Summary: Breast tumor is a heterogeneous cancer with high morbidity and mortality rates, especially in developing countries. Despite efforts to reduce its implications, the number of newly diagnosed cases is increasing worldwide. It is believed that cancer stem cells (CSCs) play a crucial role in tumor initiation, progression, metastasis, and chemotherapeutic resistance. These events are mediated by the hypoxia-inducible factor (HIF) pathway, which regulates genes involved in CSC maintenance and tumorigenesis. In this review, the mechanisms by which hypoxia or chemotherapy-induced HIFs promote breast CSC specification are discussed.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Cell Biology
Eimear O'Reilly, Hojjat Alizadeh Zeinabad, Caoimhe Nolan, Jamileh Sefy, Thomas Williams, Marina Tarunina, Diana Hernandez, Yen Choo, Eva Szegezdi
Summary: The main challenge in AML treatment is relapse, driven by quiescent LSCs in the BMM. Culturing AML cells in a 3D system can replicate the quiescence-driving BMM, providing a platform for high-throughput screening of combination drug treatments to break BMM-mediated LSC quiescence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Plant Sciences
Antoine Nicolas, Patrick Laufs
Summary: Plant aerial development relies on meristem activity, with shoot apical meristem (SAM) formed in the embryo contributing to the main stem and axillary meristems (AMs) formed post-embryonically contributing to the branched structure. This review discusses recent findings on the de novo establishment of AMs and emphasizes the progressive process of stem cell formation, different from functional meristems.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Cell Biology
Puneet Agarwal, Hui Li, Kwangmin Choi, Kathleen Hueneman, Jianbo He, Robert S. Welner, Daniel T. Starczynowski, Ravi Bhatia
Summary: Chronic myeloid leukemia is maintained and propagated by leukemia stem cells (LSCs) in bone marrow through tumor necrosis factor alpha-mediated CXCL1-CXCR2 signaling. Inhibition of CXCR2 effectively depletes CML LSCs and can enhance LSC targeting when combined with tyrosine kinase inhibitors (TKIs). TNF-alpha-induced alterations in CML BM stromal niches support LSC maintenance and growth.
Article
Multidisciplinary Sciences
Yuxuan Liu, Zhimin Gu, Hui Cao, Pranita Kaphle, Junhua Lyu, Yuannyu Zhang, Wenhuo Hu, Stephen S. Chung, Kathryn E. Dickerson, Jian Xu
Summary: Identifying how genetic alterations cooperate in driving cancer progression is challenging. This study analyzed leukemia mouse models with oncogenic NRAS and EZH2 mutations, revealing their cooperation in regulating leukemia-initiating cells and identifying GEM as a potential regulator. Integrating histopathology, leukemia repopulation, and leukemia-initiating cell assays helped validate transcriptome-based cellular profiles and elucidate the role of gene mutations in cancer evolution at single-cell resolution in vivo.
NATURE COMMUNICATIONS
(2021)
Review
Health Care Sciences & Services
Kinga Nit, Malgorzata Tyszka-Czochara, Sylwia Bobis-Wozowicz
Summary: Human-induced pluripotent stem cells offer great potential in medicine, especially for personalized drug testing and cell therapy. However, their safety and reliability must be proven. Low oxygen pressure has been found to have beneficial effects on these cells, influencing their functions and activities.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Cell Biology
Nariaki Nakamura, Xiaobing Shi, Radbod Darabi, Yong Li
Summary: Cellular reprogramming is a crucial topic in stem cell and molecular biology research, involving aspects such as cell proliferation, determination of cell fate, and stem cell renewal. Factors like hypoxia and epigenetics play significant roles in tissue and organ development during this process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Jirarat Poohadsuan, George A. O'Doherty, Weerapat Owattanapanich, Smith Kungwankiattichai, Yon Rojanasakul, Surapol Issaragrisil, Sudjit Luanpitpong
Summary: Cardiac glycosides show significant therapeutic effects on LSCs in AML, inducing apoptosis independent of cell differentiation status. The cell cycle distribution and intrinsic apoptotic regulatory mechanisms of LSCs are crucial factors determining the sensitivity to cardiac glycosides.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Medicine, Research & Experimental
Filip Matthijssens, Nitesh D. Sharma, Monique Nysus, Christian K. Nickl, Huining Kang, Dominique R. Perez, Beatrice Lintermans, Wouter Van Loocke, Juliette Roels, Sofie Peirs, Lisa Demoen, Tim Pieters, Lindy Reunes, Tim Lammens, Barbara De Moerloose, Filip Van Nieuwerburgh, Dieter L. Deforce, Laurence C. Cheung, Rishi S. Kotecha, Martijn D. P. Risseeuw, Serge Van Calenbergh, Takeshi Takarada, Yukio Yoneda, Frederik W. van Delft, Richard B. Lock, Seth D. Merkley, Alexandre Chigaev, Larry A. Sklar, Charles G. Mullighan, Mignon L. Loh, Stuart S. Winter, Stephen P. Hunger, Steven Goossens, Eliseo F. Castillo, Wojciech Ornatowski, Pieter Van Vlierberghe, Ksenia Matlawska-Wasowska
Summary: The study demonstrates that the upregulation of RUNX2 acts as a dependency factor in high-risk subtypes of human T-ALL by regulating tumor metabolism and leukemic cell migration simultaneously.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Lena-Marie Martin, Anne Kruchen, Boris Fehse, Ingo Mueller
Summary: Persistence of fetal cells in the mother's circulation has a beneficial effect on children with leukemia undergoing haploidentical hematopoietic stem cell transplantation. Maternal genetic factors and NK cells play important roles, but cytotoxicity is not solely determined by these factors.
Review
Immunology
Livius Penter, Satyen H. Gohil, Catherine J. Wu
Summary: Blood malignancies offer unique opportunities for studying disease evolution and monitoring anti-tumor immune changes. The development of single-cell sequencing technologies allows us to delve into the underlying mechanisms at an unprecedented level of detail. The identification of molecular events as in-vivo barcodes enables tracking of malignant and immune cell populations over time.
FRONTIERS IN IMMUNOLOGY
(2022)
