GeneLab Database Analyses Suggest Long-Term Impact of Space Radiation on the Cardiovascular System by the Activation of FYN Through Reactive Oxygen Species

Possible Molecular Targets of Novel Ruthenium Complexes in Antiplatelet Therapy

(2018) Thanasekaran Jayakumar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Signalling through Src family kinase isoforms is not redundant in models of thrombo-inflammatory vascular disease

(2018) Matthew J. Harrison et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Structure-Antiplatelet Activity Relationships of Novel Ruthenium (II) Complexes: Investigation of Its Molecular Targets

(2018) Chih-Hsuan Hsia et al.   MOLECULES

NASA GeneLab Project: Bridging Space Radiation Omics with Ground Studies

(2018) Afshin Beheshti et al.   RADIATION RESEARCH

Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization

(2018) Franco Cortese et al.   Oncotarget

Global transcriptomic analysis suggests carbon dioxide as an environmental stressor in spaceflight: A systems biology GeneLab case study

(2018) Afshin Beheshti et al.   Scientific Reports

FYN KYNASE IS A NOVEL MODULATOR OF ERYTHROPOIETIN SIGNALING AND STRESS ERYTHROPOIESIS

(2018) Elisabetta Beneduce et al.   AMERICAN JOURNAL OF HEMATOLOGY

A microRNA signature and TGF-β1 response were identified as the key master regulators for spaceflight response

(2018) Afshin Beheshti et al.   PLoS One

Molecular Pathways Associated With Methylmercury-Induced Nrf2 Modulation

(2018) Takamitsu Unoki et al.   Frontiers in Genetics

Phosphorylation of cardiac voltage‐gated sodium channel: Potential players with multiple dimensions

(2018) Shahid M. Iqbal et al.   Acta Physiologica

Nrf2, the Master Regulator of Anti-Oxidative Responses

(2017) Sandra Vomund et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of Oxidative Stress on Cardiovascular System in Response to Gravity

(2017) Ken Takahashi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of MicroRNAs in Myocardial Infarction: From Molecular Mechanism to Clinical Application

(2017) Teng Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heart in space: effect of the extraterrestrial environment on the cardiovascular system

(2017) Richard L. Hughson et al.   Nature Reviews Cardiology

The Omics Dashboard for interactive exploration of gene-expression data

(2017) Suzanne Paley et al.   NUCLEIC ACIDS RESEARCH

Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation

(2017) Sanae Ben Mkaddem et al.   Nature Communications

Interplay of space radiation and microgravity in DNA damage and DNA damage response

(2017) María Moreno-Villanueva et al.   NPJ Microgravity

Src- and Fyn-dependent apical membrane trafficking events control endothelial lumen formation during vascular tube morphogenesis

(2017) Dae Joong Kim et al.   PLoS One

Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma

(2016) D. Ravi et al.   CANCER RESEARCH

Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling

(2016) Shouji Matsushima et al.   JOURNAL OF CLINICAL INVESTIGATION

Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart

(2016) Igor Koturbash et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The roles of extracellular related-kinases 1 and 2 signaling in CNS myelination

(2016) David Gonsalvez et al.   NEUROPHARMACOLOGY

Interplay between oxidant species and energy metabolism

(2016) Celia Quijano et al.   Redox Biology

HZE Radiation Non-Targeted Effects on the Microenvironment That Mediate Mammary Carcinogenesis

(2016) Mary Helen Barcellos-Hoff et al.   Frontiers in Oncology

Low-dose radiation affects cardiac physiology: gene networks and molecular signaling in cardiomyocytes

(2015) Matthew A. Coleman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Host Age Is a Systemic Regulator of Gene Expression Impacting Cancer Progression

(2015) A. Beheshti et al.   CANCER RESEARCH

Toll-Like Receptors and Src-Family Kinases in Atherosclerosis　– Focus on Macrophages –

(2015) Jian-Guo Wang et al.   CIRCULATION JOURNAL

Cardiac Nonmyocytes in the Hub of Cardiac Hypertrophy

(2015) T. Kamo et al.   CIRCULATION RESEARCH

Nrf2-Mediated Cardiac Maladaptive Remodeling and Dysfunction in a Setting of Autophagy InsufficiencyNovelty and Significance

(2015) Qingyun Qin et al.   HYPERTENSION

Redox Roles of Reactive Oxygen Species in Cardiovascular Diseases

(2015) Feng He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proton irradiation impacts age-driven modulations of cancer progression influenced by immune system transcriptome modifications from splenic tissue

(2015) Justin Wage et al.   JOURNAL OF RADIATION RESEARCH

Fyn is an important molecule in cancer pathogenesis and drug resistance

(2015) Daniel Elias et al.   PHARMACOLOGICAL RESEARCH

The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review)

(2015) Hawa N. Siti et al.   VASCULAR PHARMACOLOGY

Tumor-host signaling interaction reveals a systemic, age-dependent splenic immune influence on tumor development

(2015) Afshin Beheshti et al.   Oncotarget

Cardiac Mitochondria and Reactive Oxygen Species Generation

(2014) Yeong-Renn Chen et al.   CIRCULATION RESEARCH

c-Myc Programs Fatty Acid Metabolism and Dictates Acetyl-CoA Abundance and Fate

(2014) Lia R. Edmunds et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiovascular Risks Associated with Low Dose Ionizing Particle Radiation

(2014) Xinhua Yan et al.   PLoS One

Proton Irradiation Augments the Suppression of Tumor Progression Observed with Advanced Age

(2014) Afshin Beheshti et al.   RADIATION RESEARCH

Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3β/Fyn kinase axis during oxidative hepatocellular toxicity

(2014) F Rizvi et al.   Cell Death & Disease

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

A critical role for Lyn kinase in strengthening endothelial integrity and barrier function

(2013) J. Han et al.   BLOOD

High LET56Fe ion irradiation induces tissue-specific changes in DNA methylation in the mouse

(2013) Florence Lima et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

The challenging environment on board the International Space Station affects endothelial cell function by triggering oxidative stress through thioredoxin interacting protein overexpression: the ESA-SPHINX experiment

(2013) Silvia Versari et al.   FASEB JOURNAL

Persistence of apoptosis and inflammatory responses in the heart and bone marrow of mice following whole-body exposure to 28Silicon (28Si) ions

(2013) Montree Tungjai et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

Age and Space Irradiation Modulate Tumor Progression: Implications for Carcinogenesis Risk

(2013) Afshin Beheshti et al.   RADIATION RESEARCH

Fold change and p-value cutoffs significantly alter microarray interpretations

(2012) Mark R Dalman et al.   BMC BIOINFORMATICS

Systematic Review and Meta-analysis of Circulatory Disease from Exposure to Low-Level Ionizing Radiation and Estimates of Potential Population Mortality Risks

(2012) Mark P. Little et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The influence of reactive oxygen species on cell cycle progression in mammalian cells

(2012) Eline Hendrike Verbon et al.   GENE

In Vivo Space Radiation-Induced Non-Targeted Responses: Late Effects on Molecular Signaling in Mitochondria

(2012) Mohit R. Jain et al.   Current Molecular Pharmacology

Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury

(2011) Edouard I. Azzam et al.   CANCER LETTERS

Iron-Ion Radiation Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice

(2011) Tao Yu et al.   RADIATION RESEARCH

HZE56Fe-Ion Irradiation Induces Endothelial Dysfunction in Rat Aorta: Role of Xanthine Oxidase

(2011) Kevin G. Soucy et al.   RADIATION RESEARCH

Fyn

(2010) Yoshihito D. Saito et al.   CANCER

microRNAs in heart disease: putative novel therapeutic targets?

(2010) G. Condorelli et al.   EUROPEAN HEART JOURNAL

Effects of Ionizing Radiation on Three-Dimensional Human Vessel Models: Differential Effects According to Radiation Quality and Cellular Development

(2010) Peter Grabham et al.   RADIATION RESEARCH

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

Long-term changes in rat hematopoietic and other physiological systems after high-energy iron ion irradiation

(2008) Daila S. Gridley et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY