Article
Oncology
Sho Takahashi, Shusaku Shibutani, Hiroyuki Iwata
Summary: This study investigated the relationship between the localization and phosphorylation of 4E-BP1. The results showed efficient phosphorylation of 4E-BP1 at lysosomes and the plasma membrane, while it was decreased in the nucleus. Additionally, nuclear-localized TORCAR altered cell cycle distribution and reduced cyclin D1 protein levels.
EXPERIMENTAL CELL RESEARCH
(2022)
Review
Respiratory System
Jilly F. Evans, Francis X. McCormack, Nahum Sonenberg, Vera P. Krymskaya
Summary: This article introduces the pathogenesis of LAM and the current therapeutic methods, and points out that inhibiting mTORC1-driven translation initiation may be an important strategy for treating LAM and other related diseases.
EUROPEAN RESPIRATORY REVIEW
(2023)
Review
Biochemistry & Molecular Biology
Alice Romagnoli, Mattia D'Agostino, Chiara Ardiccioni, Cristina Maracci, Stefano Motta, Anna La Teana, Daniele Di Marino
Summary: eIF4E plays a central role in controlling mRNA translation, with its interaction with eIF4G and 4E-BPs being crucial for the assembly of the translational machinery. Recent discoveries of non-canonical binding motifs could have implications for the development of new therapeutic strategies targeting eIF4E.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Immunology
Ning Wang, Ke Zhou, Zhi Liang, Ruiqi Sun, Hong Tang, Zhentao Yang, Wentao Zhao, Yiyang Peng, Penghong Song, Shusen Zheng, Haiyang Xie
Summary: A third-generation mTOR inhibitor, RapaLink-1, demonstrates effectiveness in inhibiting T-cell proliferation and prolonging graft survival time in organ transplantation. It achieves this by reducing p-4EBP1 levels in T cells, increasing Treg cell population, and decreasing Th1 and Th17 cell populations, resulting in improved rejection outcomes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jianling Xie, Kaikai Shen, Ashley T. Jones, Jian Yang, Andrew R. Tee, Ming Hong Shen, Mengyuan Yu, Swati Irani, Derick Wong, James E. Merrett, Roman Lenchine, Stuart De Poi, Kirk B. Jensen, Paul J. Trim, Marten F. Snel, Makoto Kamei, Sally Kim Martin, Stephen Fitter, Shuye Tian, Xuemin Wang, Lisa M. Butler, Andrew C. W. Zannettino, Christopher G. Proud
Summary: This study uncovers a novel feedback loop in which mTORC1 represses MNK2 activity and oncogenic signaling through eIF4E phosphorylation, providing insights into the reciprocal regulation of these two oncogenic pathways.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Immunology
Ioannis D. Dimitriou, David Meiri, Yulia Jitkova, Alisha R. Elford, Marianne Koritzinsky, Aaron D. Schimmer, Pamela S. Ohashi, Nahum Sonenberg, Robert Rottapel
Summary: In this study, the researchers found that 4E-BP1/2 proteins play a critical role in the proliferation of mouse CD8(+) T cells and the development of antiviral effector function. They also discovered that the translation of genes related to mitochondrial biogenesis is impaired in T cells derived from 4E-BP1/2-deficient mice.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Cell Biology
Yanan Wang, Jiapeng Lei, Song Zhang, Xiaomei Wang, Jiangbo Jin, Yufeng Liu, Mingxi Gan, Yi Yuan, Longhua Sun, Xiaolei Li, Tianyu Han, Jian-Bin Wang
Summary: This study discovered a novel mechanism of 4EBP1 as a cellular glucose sensor in regulating cancer cell death under glucose deprivation conditions. It found that 4EBP1 levels increased in the central region of tumors under nutrient deprivation, and it interacted with STAT3 to induce cell apoptosis.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Yifang He, Qianzhao Ji, Zeming Wu, Yusheng Cai, Jian Yin, Yiyuan Zhang, Sheng Zhang, Xiaoqian Liu, Weiqi Zhang, Guang-Hui Liu, Si Wang, Moshi Song, Jing Qu
Summary: Research shows that the expression of 4E-BP1 decreases during the senescence of human stem cells. The absence of 4E-BP1 leads to abnormal mitochondrial respiration and increased production of reactive oxygen species, resulting in accelerated cellular senescence. However, ectopic expression of 4E-BP1 can alleviate mitochondrial abnormalities and cellular senescence, maintaining mitochondrial homeostasis. This study provides a new potential target for counteracting human stem cell senescence.
Article
Plant Sciences
Ye-Rin Lee, Muhammad Irfan Siddique, Do-Sun Kim, Eun Su Lee, Koeun Han, Sang-Gyu Kim, Hye-Eun Lee
Summary: Genome editing, especially CRISPR/Cas9 technology, is a state-of-the-art approach for trait development in breeding programs. In this study, targeted mutation was generated in the eIF(iso)4E gene of a TuMV-susceptible Chinese cabbage cultivar using CRISPR/Cas9, resulting in the development of TuMV-resistant plants. The edited T-1 plants showed heritable mutations and resistance to TuMV, indicating the potential of CRISPR/Cas9 to improve traits in Chinese cabbage plants.
HORTICULTURE RESEARCH
(2023)
Article
Oncology
Fan Li, Huizhi Sun, Yue Li, Xiaoyu Bai, Xueyi Dong, Nan Zhao, Jie Meng, Baocun Sun, Danfang Zhang
Summary: The study showed that high expression of eIF4E in BRCA is associated with poor prognosis and higher recurrence rates; inhibiting eIF4E can suppress migration and invasion of BRCA cells; eIF4E may play a role in tumor macrophage infiltration and M2 polarization.
Article
Biochemistry & Molecular Biology
Patrick Senechal, Francis Robert, Regina Cencic, Akiko Yanagiya, Jennifer Chu, Nahum Sonenberg, Marilene Paquet, Jerry Pelletier
Summary: The translation initiation factor eIF4F is crucial for cap-dependent protein synthesis initiation. Different subunits of eIF4F have varying roles in development and tumorigenesis, with some being essential for viability and tumor onset, while others have non-essential functions. This study highlights the complex roles of different eIF4F subunits in gene expression regulation during embryogenesis and tumor development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yaoxiang Tang, Jiadi Luo, Yang Yang, Sile Liu, Hongmei Zheng, Yuting Zhan, Songqing Fan, Qiuyuan Wen
Summary: In patients with non-small cell lung cancer, the overexpression of phosphorylated eIF4E and 4EBP1 is associated with poor prognosis, suggesting their potential as novel prognostic markers and targeted therapy in lung cancer.
Article
Chemistry, Multidisciplinary
Reem T. Attia, Menna A. Ewida, Eman Khaled, Sherif Ashraf Fahmy, Iten M. Fawzy
Summary: Translation of mRNA is a process used by cancer cells to ensure survival, and this study explores the inhibition of eIF4E to disrupt the translation process. Synthesized GMP analogs showed high potency against breast cancer cells, and compound 4b exhibited the most activity across multiple cell lines. Chitosan-coated niosomes loaded with compound 4b showed enhanced efficacy against cancer cells, and western blot techniques revealed the inhibition of phosphorylated eIF4E expression. The findings suggest the potential use of niosomal nanovesicles as a targeted nanocarrier for cancer therapy.
Article
Cell Biology
Neha Bhat, Anand Narayanan, Mohsen Fathzadeh, Kanan Shah, Mehdi Dianatpour, Maen D. Abou Ziki, Arya Mani
Summary: Rare gain of function mutations in the gene encoding Dyrk1b are associated with sarcopenic obesity and metabolic syndrome in humans. 4e-bp1 has been identified as a post-transcriptional target of Dyrk1b in C2C12 cells. This study provides insight into the Dyrk1b-4e-bp1-autophagy axis in skeletal muscle development and disorders.
CELLULAR SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Raphael Boehm, Stefan Imseng, Roman P. Jakob, Michael N. Hall, Timm Maier, Sebastian Hiller
Summary: The study reveals that mTORC1 achieves hierarchical phosphorylation of 4E-BP1 through specific interactions, facilitating efficient activation of translation. Furthermore, mTORC1 is capable of recognizing both free and eIF4E-bound 4E-BP1, enabling rapid phosphorylation of the entire 4E-BP1 pool.
Review
Cell Biology
Asiya Batool, Sabreena Aashaq, Khurshid Iqbal Andrabi
EUROPEAN JOURNAL OF CELL BIOLOGY
(2017)
Article
Plant Sciences
Zahoor Ahmad Itoo, Qussin Basharat, Sheikh Tahir Majeed, Khurshid Iqbal Andrabi, Zafar A. Reshi
BRAZILIAN JOURNAL OF BOTANY
(2014)
Review
Biochemistry & Molecular Biology
Sabreena Aashaq, Asiya Batool, Khurshid I. Andrabi
Article
Biochemistry & Molecular Biology
Asiya Batool, Sabreena Aashaq, Khurshid I. Andrabi
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Cell Biology
Asiya Batool, Sheikh Tahir Majeed, Sabreena Aashaq, Rabiya Majeed, Nadiem Nazir Bhat, Khurshid Iqbal Andrabi
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Asiya Batool, Sheikh Tahir Majeed, Sabreena Aashaq, Rabiya Majeed, Khurshid Iqbal Andrabi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Cell Biology
Sheikh Tahir Majeed, Asiya Batool, Rabiya Majeed, Nadiem Nazir Bhat, Muhammad Afzal Zargar, Khurshid Iqbal Andrabi
Summary: Phosphorylated S209-eIF4E interacts with the TOS motif of S6K1, releasing it from auto-inhibition and priming it for activation in an mTORC1-independent manner. The role of mTORC1 is limited to engaging eIF4E with the S6K1-TOS motif to influence S6K1's state of activation.
Review
Cell Biology
Sabreena Aashaq, Asiya Batool, Shabir Ahmad Mir, Mushtaq Ahmad Beigh, Khurshid Iqbal Andrabi, Zaffar Amin Shah
Summary: TGF-beta serves as a dual role in tumor progression, acting both as a tumor suppressor in the early stages and a metastatic promoter in the later stages. The signaling pathways of TGF-beta are complex, involving both SMAD-dependent and SMAD-independent pathways.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Umer Majeed Wani, Sheikh Tahir Majeed, Vaseem Raja, Zubair Ahmad Wani, Nelofer Jan, Khursid Iqbal Andrabi, Riffat John
Summary: The study found that the cold-responsive protein1 (BoCRP1) isolated from Brassica oleracea showed significant function in response to chilling stress, leading to improved cold stress tolerance in tomato plants.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Asma Rafiq, Sabreena Aashaq, Iqra Jan, Mushtaq A. Beigh
Summary: Sine Oculis Homeobox 1 (SIX1) is a vital member of the homeobox transcription factor family, playing crucial roles in organismal development and differentiation. Its aberrant expression has been linked to hearing impairment, renal anomalies, and tumorigenesis, highlighting its importance in various pathological conditions. As a transcription factor, SIX1 primarily regulates cellular functions by controlling the expression of different proteins.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Cell Biology
Sheikh Tahir Majeed, Rabiya Majeed, Khurshid I. Andrabi
Summary: The article reviews the recent advances in our understanding of the molecular events that define the process of autophagy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)