Fibroblast growth factor 21 deficiency aggravates obesity-induced hypothalamic inflammation and impairs thermogenic response

FGF21 gene therapy as treatment for obesity and insulin resistance

(2018) Veronica Jimenez et al.   EMBO Molecular Medicine

Hypothalamic Macrophage Inducible Nitric Oxide Synthase Mediates Obesity-Associated Hypothalamic Inflammation

(2018) Chan Hee Lee et al.   Cell Reports

Fibroblast Growth Factor 21—Metabolic Role in Mice and Men

(2017) Harald Staiger et al.   ENDOCRINE REVIEWS

Hypothalamic lipid-laden astrocytes induce microglia migration and activation

(2017) Yoon-Hee Kwon et al.   FEBS LETTERS

FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice

(2017) Qingzhi Wang et al.   MOLECULAR NEUROBIOLOGY

Obesity-Induced Neuroinflammation: Beyond the Hypothalamus

(2017) Owein Guillemot-Legris et al.   TRENDS IN NEUROSCIENCES

Quercetin Protects Obesity-Induced Hypothalamic Inflammation by Reducing Microglia-Mediated Inflammatory Responses via HO-1 Induction

(2017) Jihyeon Yang et al.   Nutrients

Brain Structural Differences between Normal and Obese Adults and their Links with Lack of Perseverance, Negative Urgency and Sensation Seeking

(2017) Haifeng Wang et al.   Scientific Reports

Hypothalamic Inflammation and Energy Balance Disruptions: Spotlight on Chemokines

(2017) Ophélia Le Thuc et al.   Frontiers in Endocrinology

High fat induces acute and chronic inflammation in the hypothalamus: effect of high-fat diet, palmitate and TNF-α on appetite-regulating NPY neurons

(2016) P S Dalvi et al.   INTERNATIONAL JOURNAL OF OBESITY

FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs

(2015) K. H. Kim et al.   JOURNAL OF ENDOCRINOLOGY

Hypothalamic inflammation and gliosis in obesity

(2015) Mauricio D. Dorfman et al.   Current Opinion in Endocrinology Diabetes and Obesity

Neuronal Control of Adaptive Thermogenesis

(2015) Xiaoyong Yang et al.   Frontiers in Endocrinology

The brain and brown fat

(2014) Cristina Contreras et al.   ANNALS OF MEDICINE

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

FGF-21, a novel metabolic regulator, has a robust neuroprotective role and is markedly elevated in neurons by mood stabilizers

(2014) Y Leng et al.   MOLECULAR PSYCHIATRY

Arcuate NPY Controls Sympathetic Output and BAT Function via a Relay of Tyrosine Hydroxylase Neurons in the PVN

(2013) Yan-Chuan Shi et al.   Cell Metabolism

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

(2013) Angie L Bookout et al.   NATURE MEDICINE

Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity

(2013) Dimitris N. Xanthos et al.   NATURE REVIEWS NEUROSCIENCE

Understanding the brown adipocyte as a contributor to energy homeostasis

(2013) Kanta Chechi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Thyrotropin-Releasing Hormone (TRH) Inhibits Melanin-Concentrating Hormone Neurons: Implications for TRH-Mediated Anorexic and Arousal Actions

(2012) X. Zhang et al.   JOURNAL OF NEUROSCIENCE

Fibroblast Growth Factor 21 (FGF21) in Human Cerebrospinal Fluid

(2011) Bee K. Tan et al.   DIABETES

Low-Grade Hypothalamic Inflammation Leads to Defective Thermogenesis, Insulin Resistance, and Impaired Insulin Secretion

(2011) Ana Paula Arruda et al.   ENDOCRINOLOGY

Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats

(2010) D. A. Sarruf et al.   DIABETES

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

(2010) Klementina Fon Tacer et al.   MOLECULAR ENDOCRINOLOGY

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

FGF-21/FGF-21 receptor interaction and activation is determined by βKlotho

(2007) Alexei Kharitonenkov et al.   JOURNAL OF CELLULAR PHYSIOLOGY