Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury

TRPV4 Is Required for Hypoxic Pulmonary Vasoconstriction

(2015) Neil M. Goldenberg et al.   ANESTHESIOLOGY

TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury

(2014) Shrilatha Balakrishna et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TRPV4: an exciting new target to promote alveolocapillary barrier function

(2014) Rory E. Morty et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Differential Regulation of Lung Endothelial Permeability in Vitro and in Situ

(2014) Stefan Uhlig et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Neutrophil cell surface receptors and their intracellular signal transduction pathways

(2013) Krisztina Futosi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Central role of the exchange factor GEF-H1 in TNF-α–induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells

(2013) Faiza Waheed et al.   MOLECULAR BIOLOGY OF THE CELL

Prone Positioning in Severe Acute Respiratory Distress Syndrome

(2013) Claude Guérin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acute Respiratory Distress Syndrome

(2012)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Transient Receptor Potential Vanilloid 4 blockade protects against experimental colitis in mice: a new strategy for inflammatory bowel diseases treatment?

(2012) J. Fichna et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Soluble epoxide hydrolase regulates hematopoietic progenitor cell function via generation of fatty acid diols

(2012) T. Fromel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

(2012) Kevin S. Thorneloe et al.   Science Translational Medicine

Lung Endothelial Ca2+and Permeability Response to Platelet-Activating Factor Is Mediated by Acid Sphingomyelinase and Transient Receptor Potential Classical 6

(2011) Rudi Samapati et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An Official American Thoracic Society Workshop Report: Features and Measurements of Experimental Acute Lung Injury in Animals

(2011) Gustavo Matute-Bello et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Role of transient receptor potential vanilloid 4 in rat joint inflammation

(2011) Alexandre Denadai-Souza et al.   ARTHRITIS AND RHEUMATISM

Inhibition of Rac activity alleviates lipopolysaccharide-induced acute pulmonary injury in mice

(2011) Hong-yi Yao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Rac regulates PtdInsP3 signaling and the chemotactic compass through a redox-mediated feedback loop

(2011) J. W. P. Kuiper et al.   BLOOD

Pre-B Cell Colony-Enhancing Factor (PBEF/Nampt/Visfatin) Primes Neutrophils for Augmented Respiratory Burst Activity through Partial Assembly of the NADPH Oxidase

(2011) Z. Malam et al.   JOURNAL OF IMMUNOLOGY

TRPV4 channels augment macrophage activation and ventilator-induced lung injury

(2010) Kazutoshi Hamanaka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Therapeutic strategies for severe acute lung injury

(2010) Janet V. Diaz et al.   CRITICAL CARE MEDICINE

Channelopathies converge on TRPV4

(2010) Bernd Nilius et al.   NATURE GENETICS

TRPV2 has a pivotal role in macrophage particle binding and phagocytosis

(2010) Tiffany M Link et al.   NATURE IMMUNOLOGY

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

(2010) W. Everaerts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ca2+ entry via α1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium

(2009) Songwei Wu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mechanotransduction by TRP Channels: General Concepts and Specific Role in the Vasculature

(2009) Jun Yin et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

The calcium-conducting ion channel transient receptor potential canonical 6 is involved in macrophage inflammatory protein-2-induced migration of mouse neutrophils

(2008) N. Damann et al.   Acta Physiologica

Animal models of acute lung injury

(2008) Gustavo Matute-Bello et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Negative-Feedback Loop Attenuates Hydrostatic Lung Edema via a cGMP-Dependent Regulation of Transient Receptor Potential Vanilloid 4

(2008) Jun Yin et al.   CIRCULATION RESEARCH

IP3Receptor Binds to and Sensitizes TRPV4 Channel to Osmotic Stimuli via a Calmodulin-binding Site

(2008) Anna Garcia-Elias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Conserved Rac-binding Site on NADPH Oxidases Supports a Direct GTPase Regulatory Mechanism

(2008) Yu-Ya Kao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Real-Time PCR Detection of TRPV1–4 Gene Expression in Human Leukocytes from Healthy and Hyposensitive Subjects

(2008) Giacomo Spinsanti et al.   Molecular Pain

High Vascular Pressure–Induced Lung Injury Requires P450 Epoxygenase–Dependent Activation of TRPV4

(2007) Ming-Yuan Jian et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY