Central role of the exchange factor GEF-H1 in TNF-α–induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells
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Title
Central role of the exchange factor GEF-H1 in TNF-α–induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells
Authors
Keywords
-
Journal
MOLECULAR BIOLOGY OF THE CELL
Volume 24, Issue 7, Pages 1068-1082
Publisher
American Society for Cell Biology (ASCB)
Online
2013-02-07
DOI
10.1091/mbc.e12-09-0661
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- (2011) Yuta Yoshimura et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2011) Eli Kakiashvili et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- Direct Activation of TACE-Mediated Ectodomain Shedding by p38 MAP Kinase Regulates EGF Receptor-Dependent Cell Proliferation
- (2010) Pinglong Xu et al. MOLECULAR CELL
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- (2010) T Maretzky et al. ONCOGENE
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