Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death

Impact of DNA repair and stability defects on cortical development

(2018) Federico T. Bianchi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies

(2017) Mar Soto et al.   Cell Reports

The progeroid gene BubR1 regulates axon myelination and motor function

(2016) Chan-Il Choi et al.   Aging-US

Paclitaxel-induced aberrant mitosis and mitotic slippage efficiently lead to proliferative death irrespective of canonical apoptosis and p53

(2016) Shinji Yasuhira et al.   CELL CYCLE

Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain

(2016) Louis-Jan Pilaz et al.   NEURON

Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus

(2016) Raehee Park et al.   Nature Communications

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer

(2016) Robbyn L Weaver et al.   eLife

Molecular genetics of human primary microcephaly: an overview

(2015) Muhammad Faheem et al.   BMC Medical Genomics

A novel homozygous splicing mutation of CASC5 causes primary microcephaly in a large Pakistani family

(2015) Sandra Szczepanski et al.   HUMAN GENETICS

Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells

(2015) Akihiro Ohashi et al.   Nature Communications

Developmental disruptions underlying brain abnormalities in ciliopathies

(2015) Jiami Guo et al.   Nature Communications

The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation

(2015) Tatsuo Miyamoto et al.   Cell Reports

Cortical neurogenesis in the absence of centrioles

(2014) Ryan Insolera et al.   NATURE NEUROSCIENCE

Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size

(2014) Jian-Fu Chen et al.   Nature Communications

Centrosome amplification causes microcephaly

(2013) Véronique Marthiens et al.   NATURE CELL BIOLOGY

A Truncating Mutation of CEP135 Causes Primary Microcephaly and Disturbed Centrosomal Function

(2012) Muhammad Sajid Hussain et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Integration of Kinase and Phosphatase Activities by BUBR1 Ensures Formation of Stable Kinetochore-Microtubule Attachments

(2012) Saskia J.E. Suijkerbuijk et al.   DEVELOPMENTAL CELL

Kinetochore KMN network gene CASC5 mutated in primary microcephaly

(2012) A. Genin et al.   HUMAN MOLECULAR GENETICS

Aneuploid Cells Are Differentially Susceptible to Caspase-Mediated Death during Embryonic Cerebral Cortical Development

(2012) S. E. Peterson et al.   JOURNAL OF NEUROSCIENCE

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

(2012) Darren J. Baker et al.   NATURE CELL BIOLOGY

Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation

(2012) Tobias Wijshake et al.   PLoS Genetics

Genetic causes of microcephaly and lessons for neuronal development

(2012) Edward C. Gilmore et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates

(2011) Tatsuo Miyamoto et al.   HUMAN MOLECULAR GENETICS

BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner

(2011) Pablo Lara-Gonzalez et al.   JOURNAL OF CELL SCIENCE

Protein Interaction Domain Mapping of Human Kinetochore Protein Blinkin Reveals a Consensus Motif for Binding of Spindle Assembly Checkpoint Proteins Bub1 and BubR1

(2011) T. Kiyomitsu et al.   MOLECULAR AND CELLULAR BIOLOGY

Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase

(2011) Emily A. Foley et al.   NATURE CELL BIOLOGY

Mutations in Centrosomal Protein CEP152 in Primary Microcephaly Families Linked to MCPH4

(2010) Duane L. Guernsey et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Molecular Causes for BUBR1 Dysfunction in the Human Cancer Predisposition Syndrome Mosaic Variegated Aneuploidy

(2010) Saskia J.E. Suijkerbuijk et al.   CANCER RESEARCH

Deletion of the Parkin co-regulated gene causes defects in ependymal ciliary motility and hydrocephalus in the quakingviable mutant mouse

(2010) G. R. Wilson et al.   HUMAN MOLECULAR GENETICS

Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface

(2010) Julie P.I. Welburn et al.   MOLECULAR CELL

Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture

(2010) Timothy W Yu et al.   NATURE GENETICS

Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus

(2010) Fadel Tissir et al.   NATURE NEUROSCIENCE

HomozygousBUB1BMutation and Susceptibility to Gastrointestinal Neoplasia

(2010) Thomas Rio Frio et al.   NEW ENGLAND JOURNAL OF MEDICINE

BUB1 and BUBR1: multifaceted kinases of the cell cycle

(2010) Victor M. Bolanos-Garcia et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ependymal cells: biology and pathology

(2009) Marc R. Del Bigio   ACTA NEUROPATHOLOGICA

Mutations in STIL, Encoding a Pericentriolar and Centrosomal Protein, Cause Primary Microcephaly

(2009) Arun Kumar et al.   AMERICAN JOURNAL OF HUMAN GENETICS

BubR1 N Terminus Acts as a Soluble Inhibitor of Cyclin B Degradation by APC/CCdc20 in Interphase

(2009) Liviu A. Malureanu et al.   DEVELOPMENTAL CELL

Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1

(2009) S. Elowe et al.   JOURNAL OF CELL SCIENCE

Myosin IXa Regulates Epithelial Differentiation and Its Deficiency Results in Hydrocephalus

(2009) Marouan Abouhamed et al.   MOLECULAR BIOLOGY OF THE CELL

BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells

(2009) H Izumi et al.   ONCOGENE

Clinical and genetic heterogeneity in patients with mosaic variegated aneuploidy: Delineation of clinical subtypes

(2008) Herbert García‐Castillo et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool

(2008) N. Spassky et al.   DEVELOPMENTAL BIOLOGY

Linking Kinetochore-Microtubule Binding to the Spindle Checkpoint

(2008) Daniel J. Burke et al.   DEVELOPMENTAL CELL

CDK5RAP2 Is a Pericentriolar Protein That Functions in Centrosomal Attachment of the γ-Tubulin Ring Complex

(2007) Ka-Wing Fong et al.   MOLECULAR BIOLOGY OF THE CELL