Review
Biochemistry & Molecular Biology
Klaudia Ciesielska-Figlon, Karolina Wojciechowicz, Anna Wardowska, Katarzyna Aleksandra Lisowska
Summary: Background: Nigella sativa has been traditionally used for medicinal purposes and has known antibacterial, virucidal, fungicidal, and antiparasitic properties. However, studies on its immunomodulatory effects are limited. This review examines in vitro and in vivo research supporting the role of Nigella sativa in modulating immune responses. The results suggest its potential as a therapeutic agent for regulating immune reactions.
Article
Biotechnology & Applied Microbiology
Prathiba Gnanasekaran, Anitha Roy, Nagabhishek Sirpu Natesh, Varshini Raman, Priyanka Ganapathy, Madan Kumar Arumugam
Summary: In this study, nano thymoquinone (nTQ) was synthesized and characterized. The results showed that biologically synthesized nTQ exhibited higher activity in removing potential microbial pathogens and increasing cancer cell death compared to chemically synthesized nTQ. These findings may support the use of biosynthesis method of nTQ over the chemosynthesis method.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Infectious Diseases
Salima Tiji, Mohammed Lakrat, Yahya Rokni, El Miloud Mejdoubi, Christophe Hano, Mohamed Addi, Abdeslam Asehraou, Mostafa Mimouni
Summary: This study investigates the encapsulation of N. sativa extracts in a hydroxyapatite nanoparticle sodium silicate glass (nHap/SSG) scaffold to enhance their antimicrobial properties. The loaded scaffolds demonstrate significant antimicrobial activity against various bacterial strains, making them promising materials for medical applications.
Article
Chemistry, Medicinal
T. A. Khudoiberdiev, Yu Oshchepkova
Summary: A lipolytic enzyme was isolated from Nigella sativa seeds and optimized for maximum activity. Comparisons with Sebelipase Alfa showed that this enzyme can effectively reduce total cholesterol concentration in rats.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2022)
Article
Nutrition & Dietetics
Mona S. Almujaydil, Reham M. Algheshairy, Raghad M. Alhomaid, Hend F. Alharbi, Hoda A. Ali
Summary: This study assessed the protective effects of Nigella sativa floral honey (NS floral honey) and multi-floral honey (M-floral honey) compared to Nigella sativa oil (NS oil) against azathioprine-induced testicular degeneration in rats. Both NS floral honey and NS oil partially restored testicular function and improved sperm quality, while the effects of M-floral honey were inconclusive. Further clinical studies are needed to investigate the bioactive constituents of these substances.
Article
Pharmacology & Pharmacy
Amin F. Majdalawieh, Sarah M. Yousef, Imad A. Abu-Yousef
Summary: Atherosclerosis is a prevalent chronic arterial disease characterized by dyslipidemia and inflammation, with Thymoquinone (TQ) from Nigella sativa seeds showing potential as a natural therapeutic agent for its anti-atherosclerotic effects. Studies support TQ's ability to combat key hallmarks of atherosclerosis, such as hyperlipidemia and inflammation, while also preventing foam cell formation. Experimental evidence suggests TQ could be a safe and natural therapeutic option against atherosclerosis and its complications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Saad A. Alkahtani, Ali Mohamed Alshabi, Basel A. Abdel-Wahab, Adel Aljadaan, Ibrahim Ahmed Shaikh, Masood Medleri Khateeb, Mohammed Shafiuddin Habeeb
Summary: The study found that Nigella sativa oil and honey have antinociceptive effects, and concurrent administration enhances the antinociceptive effect, shortens the onset time, and prolongs the duration.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Bushra Javaid, Nadia Majeed, Farah Deeba, Amna Muhammad, M. Sheeraz Ahmad, Ata Ur Rehman, Christopher Blanchard, S. M. Saqlan Naqvi
Summary: Protease inhibitors are a diverse group of molecules present in all organisms, with the ability to regulate intracellular proteolysis as well as inactivate proteases from predators/pathogens. Extracts from Nigella sativa seeds contain proteins with trypsin inhibitory activity, which can be extracted and isolated through ammonium sulphate precipitation. These protein extracts may have health-promoting effects against important proteases like Dipeptidyl peptidase-IV and angiotensin-converting enzyme, suggesting a potential use in managing hypertension.
PAKISTAN JOURNAL OF AGRICULTURAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Subha Veeramani, Arya P. Narayanan, Kousika Yuvaraj, Ramachandran Sivaramakrishnan, Arivalagan Pugazhendhi, Ilangovan Rishivarathan, Sujin P. Jose, Rajangam Ilangovan
Summary: In this investigation, gold nanoparticles (Au-NPs) with anti-diabetic properties were synthesized using a plant-based method. The seed extract of Nigella sativa acted as a reducing agent and coating material for the Au-NPs. The synthesized Au-NPs exhibited good antioxidant activity and significant anti-diabetic properties. The size of the nanoparticles was confirmed by SEM and TEM, while the presence of functional groups was analyzed using FTIR.
PROCESS BIOCHEMISTRY
(2022)
Article
Infectious Diseases
Anna S. Barashkova, Vera S. Sadykova, Victoria A. Salo, Sergey K. Zavriev, Eugene A. Rogozhin
Summary: High-cationic biologically active peptides, termed Nigellothionins, were isolated from black cumin seeds and classified as class I thionin subfamily members. These peptides play a role in plant innate immunity and exhibit antifungal properties. Nigellothionins show potential as natural compounds for antifungal and anti-proliferative applications based on their cytotoxic and antifungal activities.
Article
Biochemistry & Molecular Biology
Hussah Abdullah Alshwyeh, Sahar Khamees Aldosary, Muna Abdulsalam Ilowefah, Raheem Shahzad, Adeeb Shehzad, Saqib Bilal, In-Jung Lee, Jannah Ahmed Al Mater, Fatima Najf Al-Shakhoari, Waad Abdulrahman Alqahtani, Nurkhalida Kamal, Ahmed Mediani
Summary: Nigella species, particularly the roasted seeds, have been found to have various health benefits due to the presence of bioactive components. This study investigated the effect of roasting on the composition and biological activities of Nigella arvensis and Nigella sativa seed extracts. The results showed that roasted seeds exhibited strong antimicrobial activities and extracts significantly decreased cancer cell viability.
Review
Immunology
Asha Caroline Cyril, Najma Mohamed Ali, Anagha Nelliyulla Parambath, Cijo George Vazhappilly, Reem Kais Jan, Noushad Karuvantevida, Haneen Aburamadan, Yosra Lozon, Rajan Radhakrishnan
Summary: Recent studies have shown that extracts from Nigella sativa may have the potential to prevent the entry of SARS-CoV-2 into host cells and treat COVID-19 symptoms. Active compounds from Nigella sativa could potentially interfere with the binding between the virus and host cells. These studies provide evidence for the potential use of Nigella sativa in combating the pandemic.
INFLAMMOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Nethi Walia, Ajeet Sidana, Priti Arun, Gurjit Kaur, Vishal Sharma
Summary: The study found that telomerase activity was higher in drug-naive patients with major depressive disorder (MDD) compared to healthy controls, and it was significantly correlated with the severity of depression. Non-responders had significantly higher telomerase activity compared to responders, indicating telomerase activity as a potential biomarker in the underlying biological mechanism of MDD and response to antidepressant pharmacotherapy.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Chemistry, Physical
Kishore Chand, Cheng Jiao, Muhammad Nazim Lakhan, Ahmer Hussain Shah, Vinod Kumar, Diaa Eldin Fouad, Muhammad Basit Chandio, Asif Ali Maitlo, Mukhtiar Ahmed, Dianxue Cao
Summary: This study introduces a new method for synthesis of silver nanoparticles using Nigella Sativa extract, which acts as a stabilizing and reducing agent. Various characterization techniques were used to study the synthesized AgNPs, demonstrating strong photo catalytic activity in degrading Congo red dye due to high energy and smaller particle size.
CHEMICAL PHYSICS LETTERS
(2021)
Review
Biochemistry & Molecular Biology
Mohammed Dalli, Oussama Bekkouch, Salah-eddine Azizi, Ali Azghar, Nadia Gseyra, Bonglee Kim
Summary: This review analyzes the bioactive compounds and pharmacological activities of Nigella sativa, based on a multitude of research articles. It provides guidance for future studies in this field.
Article
Food Science & Technology
Parisa Solhi, Sodeif Azadmard-Damirchi, Javad Hesari, Hamed Hamishehkar
INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY
(2020)
Article
Food Science & Technology
Yeganeh Mazaheri, Mohammadali Torbati, Sodeif Azadmard-Damirchi, Geoffrey P. Savage
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2019)
Article
Agriculture, Multidisciplinary
Afsaneh Dehghan-Manshadi, Seyed Hadi Peighambardoust, Sodeif Azadmard-Damirchi, Mehrdad Niakousari
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2020)
Article
Chemistry, Applied
Arezoo Fekri, Mohammadali Torbati, Ahmad Yari Khosrowshahi, Hasan Bagherpour Shamloo, Sodeif Azadmard-Damirchi
Article
Food Science & Technology
Parisa Solhi, Sodeif Azadmard-Damirchi, Javad Hesari, Hamed Hamishehkar
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2020)
Article
Food Science & Technology
Parisa Nasirpour-Tabrizi, Sodeif Azadmard-Damirchi, Javad Hesari, Maryam Khakbaz Heshmati, Geoffrey P. Savage
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2020)
Article
Medicine, General & Internal
Ebrahim Afkhami Saray, Sodeif Azadmard-Damirchi, Mahdi Gharekhani
Summary: This study evaluated the effects of rosmarinic acid and thymoquinone on tumor growth inhibition and apoptotic induction of docetaxel in MDA-MB231 breast cancer cells. The results showed that the combination of rosmarinic acid and thymoquinone with docetaxel significantly enhanced the anti-proliferative and apoptosis-inducing effects of docetaxel, through the inhibition of the NF-kappa B pathway and modulation of apoptotic gene expression.
CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Applied
Maryam Naebi, Mohammadali Torbati, Sodeif Azadmard-Damirchi, Shahla Siabi, Geoffrey P. Savage
Summary: This research studied the effect of seed moisture content on the oil yield and quality of Balangu oil. The results showed that the optimal moisture content was 7.5%, which resulted in the highest oil yield. During storage, the physicochemical characteristics of the oil changed, with some components increasing and others decreasing. Overall, Balangu oil is an excellent source of edible vegetable oil.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Horticulture
Soheila Dastborhan, Kazem Ghassemi-Golezani, Sodeif Azadmard-Damirchi, Andrzej Kalisz
Summary: Two field experiments were conducted to investigate the effects of irrigation intervals and seed pretreatments on secondary metabolites of borage. The results showed that moderate and severe water limitations enhanced the saponin, tannin, and mucilage contents of borage leaves, while seed pretreatment with KNO3 and KH2PO4 increased the saponin content. Severe water deficit also led to a reduction in grain yield and oil yield of borage.
JOURNAL OF HORTICULTURAL SCIENCE & BIOTECHNOLOGY
(2022)
Article
Food Science & Technology
Mir-Hossein Mousavi, Mehdi Gharekhani, Kazem Alirezalu, Leila Roufegarinejad, Sodeif Azadmard-Damirchi
Summary: The present study aimed to optimize the formulation of buckwheat/lentil gluten-free beverages and evaluate their physicochemical parameters. The results showed a decrease in the viability of lactobacilli and bifidobacteria during fermentation, with sustained viability during storage.
FOOD SCIENCE & NUTRITION
(2023)
Review
Pharmacology & Pharmacy
Fataneh Hashempour-Baltork, Parastou Farshi, Adel Mirza Alizadeh, Sevda Eskandarzadeh, Solmaz Abedinzadeh, Sodeif Azadmard-Damirchi, Mohammadali Torbati
Summary: Neurodegenerative diseases are a prominent class of neurological diseases that cannot be cured. The review focuses on the effect of refined or unrefined vegetable oil consumption as a preventive or aiding strategy to slow or halt the progression of neurodegenerative diseases.
ADVANCED PHARMACEUTICAL BULLETIN
(2023)
Article
Food Science & Technology
Bahareh Daei, Sodeif Azadmard-Damirchi, Afshin Javadi, Mohammadali Torbati
Summary: This study investigated the effects of two mild thermal processing (MTP) methods on some physicochemical properties of truffles. The results showed that 5% vinegar treatment with 63℃ MTP was effective in reducing weight loss, microbial spoilage, and increasing firmness of truffles during storage. However, it led to a decrease in phenolic compounds and ascorbic acid content. Both MTPs inhibited microbial load, with the 63℃, 3 min MTP being the most effective.
Article
Food Science & Technology
Hashem Andishmand, Behzad Masoumi, Mohammadali Torbati, Aziz Homayouni-Rad, Sodeif Azadmard-Damirchi, Hamed Hamishehkar
Summary: Recent studies have shown that pomegranate peel has valuable phenolic compounds and can be converted from environmental pollutant waste to wealth. This research determined the intensifying effects of ultrasonication and dynamic maceration-assisted extraction methods and optimized the conditions to obtain maximum extraction efficiency of pomegranate peel extract.
FOOD SCIENCE & NUTRITION
(2023)
Article
Agronomy
Zeinab Dezashibi, Sodeif Azadmard-Damirchi, Zahra Piravi-Vanak
Summary: Adding 5% green tea leaves during the extraction of pomegranate seed oil using cold-press method can improve the oil quality and oxidation stability, without the need for additional antioxidant extraction. It is cost-effective, time-efficient, and does not use any chemicals.
OCL-OILSEEDS AND FATS CROPS AND LIPIDS
(2022)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
