Human challenge models: tools to accelerate the development of malaria vaccines

Safety, Immunogenicity, and Protective Efficacy against Controlled Human Malaria Infection of Plasmodium falciparum Sporozoites Vaccine in Tanzanian Adults

(2018) Said A. Jongo et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Malaria Vaccines: Recent Advances and New Horizons

(2018) Simon J. Draper et al.   Cell Host & Microbe

A controlled human malaria infection model enabling evaluation of transmission-blocking interventions

(2018) Katharine A. Collins et al.   JOURNAL OF CLINICAL INVESTIGATION

Early Changes in CD4+ T-Cell Activation During Blood-Stage Plasmodium falciparum Infection

(2018) Chelsea L Edwards et al.   JOURNAL OF INFECTIOUS DISEASES

Immunization of Malaria-Preexposed Volunteers With PfSPZ Vaccine Elicits Long-Lived IgM Invasion-Inhibitory and Complement-Fixing Antibodies

(2018) Isabelle Zenklusen et al.   JOURNAL OF INFECTIOUS DISEASES

A new site of attack for a malaria vaccine

(2018) Simon J Draper et al.   NATURE MEDICINE

A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein

(2018) Joshua Tan et al.   NATURE MEDICINE

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

(2018) Neville K Kisalu et al.   NATURE MEDICINE

GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing

(2018) Michael Filarsky et al.   SCIENCE

RTS,S/AS01 malaria vaccine mismatch observed among Plasmodium falciparum isolates from southern and central Africa and globally

(2018) Julia C. Pringle et al.   Scientific Reports

Blood-stage Challenge for Malaria Vaccine Efficacy Trials: A Pilot Study with Discussion of Safety and Potential Value

(2018) Frances Sanderson et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial

(2018) Rebecca Pawliw et al.   MALARIA JOURNAL

Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure

(2018) Isabel Rodriguez-Barraquer et al.   eLife

Blood schizonticidal activity and safety of tafenoquine when administered as chemoprophylaxis to healthy, non-immune participants followed by blood stage Plasmodium falciparum challenge: A randomized, double-blinded, placebo-controlled Phase 1b study

(2018) James S McCarthy et al.   CLINICAL INFECTIOUS DISEASES

Malaria prevention: from immunological concepts to effective vaccines and protective antibodies

(2018) Ian A. Cockburn et al.   NATURE IMMUNOLOGY

Combating multidrug-resistant Plasmodium falciparum malaria

(2017) Aung Myint Thu et al.   FEBS Journal

Vaccine candidate discovery for the next generation of malaria vaccines

(2017) James Tuju et al.   IMMUNOLOGY

γδ T Cells Are Required for the Induction of Sterile Immunity during Irradiated Sporozoite Vaccinations

(2017) Irfan Zaidi et al.   JOURNAL OF IMMUNOLOGY

Safety and efficacy of PfSPZ Vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double-blind phase 1 trial

(2017) Mahamadou S Sissoko et al.   LANCET INFECTIOUS DISEASES

Comparison of statistical models to estimate parasite growth rate in the induced blood stage malaria model

(2017) Leesa F. Wockner et al.   MALARIA JOURNAL

Sterile protection against human malaria by chemoattenuated PfSPZ vaccine

(2017) Benjamin Mordmüller et al.   NATURE

Attenuated PfSPZ Vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection

(2017) Kirsten E. Lyke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infectivity of Plasmodium falciparum sporozoites determines emerging parasitemia in infected volunteers

(2017) Matthew B. B. McCall et al.   Science Translational Medicine

Plasmodium vivax Controlled Human Malaria Infection – Progress and Prospects

(2017) Ruth O. Payne et al.   TRENDS IN PARASITOLOGY

The frontline of controlled human malaria infections: A report from the controlled human infection models Workshop in Leiden University Medical Centre 5 May 2016

(2017) Meta Roestenberg et al.   VACCINE

The Power of Malaria Vaccine Trials Using Controlled Human Malaria Infection

(2017) Luc E. Coffeng et al.   PLoS Computational Biology

Developing transmission-blocking strategies for malaria control

(2017) Robert E. Sinden   PLoS Pathogens

Novel Plasmodium antigens identified via genome-based antibody screen induce protection associated with polyfunctional T cell responses

(2017) Sophie Schussek et al.   Scientific Reports

Vaccination in early life: standing up to the challenges

(2016) Elodie Mohr et al.   CURRENT OPINION IN IMMUNOLOGY

Development of whole sporozoite malaria vaccines

(2016) Michael R. Hollingdale et al.   Expert Review of Vaccines

Liver-Resident Memory CD8 + T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

(2016) Daniel Fernandez-Ruiz et al.   IMMUNITY

Infectivity of Plasmodium falciparum in Malaria-Naive Individuals Is Related to Knob Expression and Cytoadherence of the Parasite

(2016) Danielle I. Stanisic et al.   INFECTION AND IMMUNITY

Demonstration of the Blood-StagePlasmodium falciparumControlled Human Malaria Infection Model to Assess Efficacy of theP. falciparumApical Membrane Antigen 1 Vaccine, FMP2.1/AS01

(2016) Ruth O. Payne et al.   JOURNAL OF INFECTIOUS DISEASES

Piperaquine Monotherapy of Drug-SusceptiblePlasmodium falciparumInfection Results in Rapid Clearance of Parasitemia but Is Followed by the Appearance of Gametocytemia

(2016) Cielo J. Pasay et al.   JOURNAL OF INFECTIOUS DISEASES

Fractional Third and Fourth Dose of RTS,S/AS01 Malaria Candidate Vaccine: A Phase 2a Controlled Human Malaria Parasite Infection and Immunogenicity Study

(2016) Jason A. Regules et al.   JOURNAL OF INFECTIOUS DISEASES

Protection against malaria at 1 year and immune correlates following PfSPZ vaccination

(2016) Andrew S Ishizuka et al.   NATURE MEDICINE

Immune activation and induction of memory: lessons learned from controlled human malaria infection with Plasmodium falciparum

(2016) ANJA SCHOLZEN et al.   PARASITOLOGY

Systems Approaches towards Molecular Profiling of Human Immunity

(2016) Julie G. Burel et al.   TRENDS IN IMMUNOLOGY

Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection

(2016) Marcela Montes de Oca et al.   Cell Reports

Protective Efficacy of Plasmodium vivax Radiation-Attenuated Sporozoites in Colombian Volunteers: A Randomized Controlled Trial

(2016) Myriam Arévalo-Herrera et al.   PLoS Neglected Tropical Diseases

Phase 1/2a Trial of Plasmodium vivax Malaria Vaccine Candidate VMP001/AS01B in Malaria-Naive Adults: Safety, Immunogenicity, and Efficacy

(2016) Jason W. Bennett et al.   PLoS Neglected Tropical Diseases

Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria Transmission

(2016) Paul Griffin et al.   PLoS Neglected Tropical Diseases

Plasmodium vivax but Not Plasmodium falciparum Blood-Stage Infection in Humans Is Associated with the Expansion of a CD8+ T Cell Population with Cytotoxic Potential

(2016) Julie G. Burel et al.   PLoS Neglected Tropical Diseases

Reduced Plasmodium Parasite Burden Associates with CD38+ CD4+ T Cells Displaying Cytolytic Potential and Impaired IFN-γ Production

(2016) Julie G. Burel et al.   PLoS Pathogens

Changes in Serological Immunology Measures in UK and Kenyan Adults Post-controlled Human Malaria Infection

(2016) Susanne H. Hodgson et al.   Frontiers in Microbiology

Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

(2015)   LANCET

Controlled human malaria infection by intramuscular and direct venous inoculation of cryopreserved Plasmodium falciparum sporozoites in malaria-naïve volunteers: effect of injection volume and dose on infectivity rates

(2015) Gloria P Gómez-Pérez et al.   MALARIA JOURNAL

Lessons learnt from the first controlled human malaria infection study conducted in Nairobi, Kenya

(2015) Susanne H Hodgson et al.   MALARIA JOURNAL

Development of cultured Plasmodium falciparum blood-stage malaria cell banks for early phase in vivo clinical trial assessment of anti-malaria drugs and vaccines

(2015) Danielle I Stanisic et al.   MALARIA JOURNAL

Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine

(2015) Daniel E. Neafsey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Heterologous Protection against Malaria after Immunization with Plasmodium falciparum Sporozoites

(2015) Remko Schats et al.   PLoS One

Transcriptional changes induced by candidate malaria vaccines and correlation with protection against malaria in a human challenge model

(2015) Susanna Dunachie et al.   VACCINE

Designing malaria vaccines to circumvent antigen variability

(2015) Amed Ouattara et al.   VACCINE

Large screen approaches to identify novel malaria vaccine candidates

(2015) D. Huw Davies et al.   VACCINE

Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines

(2015) Thomas L. Richie et al.   VACCINE

Mosquitoes Reset Malaria Parasites

(2015) Philip J. Spence et al.   PLoS Pathogens

Controlled Human Malaria Infection of Tanzanians by Intradermal Injection of Aseptic, Purified, Cryopreserved Plasmodium falciparum Sporozoites

(2014) Seif Shekalaghe et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

The hunt for protective correlates of immunity to Plasmodium falciparummalaria

(2014) Ann M Moormann et al.   BMC Medicine

Correlates of protective immunity following whole sporozoite vaccination against malaria

(2014) Katherine L. Doll et al.   IMMUNOLOGIC RESEARCH

Memory B-Cell and Antibody Responses Induced by Plasmodium falciparum Sporozoite Immunization

(2014) Wiebke Nahrendorf et al.   JOURNAL OF INFECTIOUS DISEASES

The Chemokine Receptor CXCR6 Is Required for the Maintenance of Liver Memory CD8+ T Cells Specific for Infectious Pathogens

(2014) Sze-Wah Tse et al.   JOURNAL OF INFECTIOUS DISEASES

Sporozoite immunization of human volunteers under chemoprophylaxis induces functional antibodies against pre-erythrocytic stages of Plasmodium falciparum

(2014) Marije C Behet et al.   MALARIA JOURNAL

RTS,S Vaccination Is Associated With Serologic Evidence of Decreased Exposure toPlasmodium falciparumLiver- and Blood-Stage Parasites

(2014) Joe J. Campo et al.   MOLECULAR & CELLULAR PROTEOMICS

Plasmodium vivax Sporozoite Challenge in Malaria-Naïve and Semi-Immune Colombian Volunteers

(2014) Myriam Arévalo-Herrera et al.   PLoS One

Efficacy and Safety of the RTS,S/AS01 Malaria Vaccine during 18 Months after Vaccination: A Phase 3 Randomized, Controlled Trial in Children and Young Infants at 11 African Sites

(2014)   PLOS MEDICINE

Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection

(2014) Susanne H. Hodgson et al.   Frontiers in Microbiology

Strategies for Designing and Monitoring Malaria Vaccines Targeting Diverse Antigens

(2014) Alyssa E. Barry et al.   Frontiers in Immunology

Comparison of Modeling Methods to Determine Liver-to-blood Inocula and Parasite Multiplication Rates During Controlled Human Malaria Infection

(2013) Alexander D. Douglas et al.   JOURNAL OF INFECTIOUS DISEASES

Experimentally Induced Blood-Stage Plasmodium vivax Infection in Healthy Volunteers

(2013) James S. McCarthy et al.   JOURNAL OF INFECTIOUS DISEASES

Malaria vaccine technology roadmap

(2013) Vasee S Moorthy et al.   LANCET

Primaquine Failure and Cytochrome P-450 2D6 in Plasmodium vivax Malaria

(2013) Jason W. Bennett et al.   NEW ENGLAND JOURNAL OF MEDICINE

Successful Human Infection with P. falciparum Using Three Aseptic Anopheles stephensi Mosquitoes: A New Model for Controlled Human Malaria Infection

(2013) Matthew B. Laurens et al.   PLoS One

Functional Limitations of Plasmacytoid Dendritic Cells Limit Type I Interferon, T Cell Responses and Virus Control in Early Life

(2013) Elodie Belnoue et al.   PLoS One

Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity

(2013) E. M. Bijker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pre-erythrocytic antibody profiles induced by controlled human malaria infections in healthy volunteers under chloroquine prophylaxis

(2013) Philip L. Felgner et al.   Scientific Reports

Controlled Human Blood Stage Malaria Infection: Current Status and Potential Applications

(2012) Christopher J. A. Duncan et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Controlled Human Malaria Infections by Intradermal Injection of Cryopreserved Plasmodium falciparum Sporozoites

(2012) Meta Roestenberg et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

NF135.C10: A New Plasmodium falciparum Clone for Controlled Human Malaria Infections

(2012) Anne C. Teirlinck et al.   JOURNAL OF INFECTIOUS DISEASES

A consultation on the optimization of controlled human malaria infection by mosquito bite for evaluation of candidate malaria vaccines

(2012) Matthew B. Laurens et al.   VACCINE

Consistent Safety and Infectivity in Sporozoite Challenge Model of Plasmodium vivax in Malaria-Naive Human Volunteers

(2011) Sócrates Herrera et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination

(2011) T. Bousema et al.   CLINICAL MICROBIOLOGY REVIEWS

Substantially Reduced Pre-patent Parasite Multiplication Rates Are Associated With Naturally Acquired Immunity to Plasmodium falciparum

(2011) A. D. Douglas et al.   JOURNAL OF INFECTIOUS DISEASES

Sterile Protective Immunity to Malaria is Associated with a Panel of NovelP. falciparumAntigens

(2011) Angela Trieu et al.   MOLECULAR & CELLULAR PROTEOMICS

Vaccines against malaria

(2011) A. V. S. Hill   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Impact on Malaria Parasite Multiplication Rates in Infected Volunteers of the Protein-in-Adjuvant Vaccine AMA1-C1/Alhydrogel+CPG 7909

(2011) Christopher J. A. Duncan et al.   PLoS One

A Pilot Randomised Trial of Induced Blood-Stage Plasmodium falciparum Infections in Healthy Volunteers for Testing Efficacy of New Antimalarial Drugs

(2011) James S. McCarthy et al.   PLoS One

The contribution of Plasmodium chabaudi to our understanding of malaria

(2011) Robin Stephens et al.   TRENDS IN PARASITOLOGY

Longevity and Composition of Cellular Immune Responses Following Experimental Plasmodium falciparum Malaria Infection in Humans

(2011) Anne C. Teirlinck et al.   PLoS Pathogens

Regulatory T cells in human geohelminth infection suppress immune responses to BCG andPlasmodium falciparum

(2010) Linda J. Wammes et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray

(2010) P. D. Crompton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Successful Sporozoite Challenge Model in Human Volunteers with Plasmodium vivax Strain Derived from Human Donors

(2009) Sócrates Herrera et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Acquired Immunity to Malaria

(2009) D. L. Doolan et al.   CLINICAL MICROBIOLOGY REVIEWS

Protection against a Malaria Challenge by Sporozoite Inoculation

(2009) Meta Roestenberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impact of RTS,S/AS02A and RTS,S/AS01B on Genotypes of P. falciparum in Adults Participating in a Malaria Vaccine Clinical Trial

(2009) John N. Waitumbi et al.   PLoS One

Contrasting Population Structures of the Genes Encoding Ten Leading Vaccine-Candidate Antigens of the Human Malaria Parasite, Plasmodium falciparum

(2009) Alyssa E. Barry et al.   PLoS One

Profiling humoral immune responses to P. falciparum infection with protein microarrays

(2008) Denise L. Doolan et al.   PROTEOMICS