The Power of Malaria Vaccine Trials Using Controlled Human Malaria Infection

Design, recruitment, and microbiological considerations in human challenge studies

(2015) Thomas C Darton et al.   LANCET INFECTIOUS DISEASES

Memory B-Cell and Antibody Responses Induced by Plasmodium falciparum Sporozoite Immunization

(2014) Wiebke Nahrendorf et al.   JOURNAL OF INFECTIOUS DISEASES

Sequential Phase 1 and Phase 2 randomized, controlled trials of the safety, immunogenicity and efficacy of combined pre-erythrocytic vaccine antigens RTS,S and TRAP formulated with AS02 Adjuvant System in healthy, malaria naïve adults

(2014) Kent E. Kester et al.   VACCINE

Comparison of Modeling Methods to Determine Liver-to-blood Inocula and Parasite Multiplication Rates During Controlled Human Malaria Infection

(2013) Alexander D. Douglas et al.   JOURNAL OF INFECTIOUS DISEASES

Efficacy of RTS,S malaria vaccines: individual-participant pooled analysis of phase 2 data

(2013) Philip Bejon et al.   LANCET INFECTIOUS DISEASES

Optimising Controlled Human Malaria Infection Studies Using Cryopreserved P. falciparum Parasites Administered by Needle and Syringe

(2013) Susanne H. Sheehy et al.   PLoS One

Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity

(2013) E. M. Bijker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlled Human Malaria Infections by Intradermal Injection of Cryopreserved Plasmodium falciparum Sporozoites

(2012) Meta Roestenberg et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Efficacy of Preerythrocytic and Blood-Stage Malaria Vaccines Can Be Assessed in Small Sporozoite Challenge Trials in Human Volunteers

(2012) M. Roestenberg et al.   JOURNAL OF INFECTIOUS DISEASES

NF135.C10: A New Plasmodium falciparum Clone for Controlled Human Malaria Infections

(2012) Anne C. Teirlinck et al.   JOURNAL OF INFECTIOUS DISEASES

A review of malaria vaccine clinical projects based on the WHO rainbow table

(2012) Lauren Schwartz et al.   MALARIA JOURNAL

ChAd63-MVA–vectored Blood-stage Malaria Vaccines Targeting MSP1 and AMA1: Assessment of Efficacy Against Mosquito Bite Challenge in Humans

(2012) Susanne H Sheehy et al.   MOLECULAR THERAPY

Comparison of Clinical and Parasitological Data from Controlled Human Malaria Infection Trials

(2012) Meta Roestenberg et al.   PLoS One

Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study

(2011) Meta Roestenberg et al.   LANCET

Randomized, Double‐Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria‐Naive Adults: Safety, Efficacy, and Immunologic Associates of Protection

(2009) Kent E. Kester et al.   JOURNAL OF INFECTIOUS DISEASES

Protection against a Malaria Challenge by Sporozoite Inoculation

(2009) Meta Roestenberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer

(2009) Christian W. Wang et al.   PARASITOLOGY INTERNATIONAL

Phase 1/2a Study of the Malaria Vaccine Candidate Apical Membrane Antigen-1 (AMA-1) Administered in Adjuvant System AS01B or AS02A

(2009) Michele D. Spring et al.   PLoS One

Report of a Consultation on the Optimization of Clinical Challenge Trials for Evaluation of Candidate Blood Stage Malaria Vaccines, 18–19 March 2009, Bethesda, MD, USA

(2009) V.S. Moorthy et al.   VACCINE