Epigenomic profiling of newborns with isolated orofacial clefts reveals widespread DNA methylation changes and implicates metastable epiallele regions in disease risk

The long-term impact of folic acid in pregnancy on offspring DNA methylation: follow-up of the Aberdeen Folic Acid Supplementation Trial (AFAST)

(2018) Rebecca C Richmond et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Maternal Folic Acid Supplementation and the Risk of Oral Clefts in Offspring

(2018) Arezoo Jahanbin et al.   JOURNAL OF CRANIOFACIAL SURGERY

Establishment of environmentally sensitive DNA methylation states in the very early human embryo

(2018) Noah J. Kessler et al.   Science Advances

DNA Methylome Profiling on the Infinium HumanMethylation450 Array from Limiting Quantities of Genomic DNA from a Single, Small Archived Bloodspot

(2017) Kripa Asrani et al.   Genetic Testing and Molecular Biomarkers

Impact of cytosine methylation on DNA binding specificities of human transcription factors

(2017) Yimeng Yin et al.   SCIENCE

Genome-wide methylation data mirror ancestry information

(2017) Elior Rahmani et al.   Epigenetics & Chromatin

Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity

(2017) Yanqin Yu et al.   Nature Communications

Distinct DNA methylation profiles in subtypes of orofacial cleft

(2017) Gemma C. Sharp et al.   Clinical Epigenetics

Differential methylation is associated with non-syndromic cleft lip and palate and contributes to penetrance effects

(2017) Lucas Alvizi et al.   Scientific Reports

Sequence variation in folate pathway genes and risks of human cleft lip with or without cleft palate

(2016) Nicholas J. Marini et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Folic acid fortification and prevalences of neural tube defects, orofacial clefts, and gastroschisis in California, 1989 to 2010

(2016) Wei Yang et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Sparse PCA corrects for cell type heterogeneity in epigenome-wide association studies

(2016) Elior Rahmani et al.   NATURE METHODS

Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns

(2016) Bonnie R. Joubert et al.   Nature Communications

Folic acid fortification and prevalences of neural tube defects, orofacial clefts, and gastroschisis in California, 1989 to 2010

(2016) Wei Yang et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Identification of Functional Variants for Cleft Lip with or without Cleft Palate in or near PAX7, FGFR2, and NOG by Targeted Sequencing of GWAS Loci

(2015) Elizabeth J. Leslie et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes

(2015) Semira Gonseth et al.   Epigenetics

Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment

(2015) Matt J Silver et al.   GENOME BIOLOGY

Epigenetic mechanism causes Wnt9b deficiency and nonsyndromic cleft lip and palate in the A/WySn mouse strain

(2014) Diana M. Juriloff et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Genome-wide DNA methylation profiling identifies a folate-sensitive region of differential methylation upstream of ZFP57-imprinting regulator in humans

(2014) Manori Amarasekera et al.   FASEB JOURNAL

DNA methylation dynamics of the human preimplantation embryo

(2014) Zachary D. Smith et al.   NATURE

Maternal nutrition at conception modulates DNA methylation of human metastable epialleles

(2014) Paula Dominguez-Salas et al.   Nature Communications

Genome-Wide Analysis of DNA Methylation Dynamics during Early Human Development

(2014) Hiroaki Okae et al.   PLoS Genetics

Folic acid supplementation use and the MTHFR C677T polymorphism in orofacial clefts etiology: An individual participant data pooled-analysis

(2013) Azeez Butali et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Developmental profiles of the murine palatal methylome

(2013) Ratnam S. Seelan et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

(2013) Yi-an Chen et al.   Epigenetics

The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development

(2013) Sara E. Billings et al.   FASEB JOURNAL

Periconceptional nutrient intakes and risks of orofacial clefts in California

(2013) Matthew B. Wallenstein et al.   PEDIATRIC RESEARCH

Epigenetic regulation ofSox4during palate development

(2013) Ratnam S Seelan et al.   Epigenomics

Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development

(2012) Y.-R. Jin et al.   DEVELOPMENT

Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies

(2012) Andrew E Jaffe et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genetic and Non-Genetic Influences during Pregnancy on Infant Global and Site Specific DNA Methylation: Role for Folate Gene Variants and Vitamin B12

(2012) Jill A. McKay et al.   PLoS One

Biological and epidemiological evidence of interaction of infant genotypes at Rs7205289 and maternal passive smoking in cleft palate

(2011) Ling Li et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Ephrin-B reverse signaling controls septation events at the embryonic midline through separate tyrosine phosphorylation-independent signaling avenues

(2011) Christopher Dravis et al.   DEVELOPMENTAL BIOLOGY

A Conserved Pbx-Wnt-p63-Irf6 Regulatory Module Controls Face Morphogenesis by Promoting Epithelial Apoptosis

(2011) Elisabetta Ferretti et al.   DEVELOPMENTAL CELL

Cleft lip and palate: understanding genetic and environmental influences

(2011) Michael J. Dixon et al.   NATURE REVIEWS GENETICS

Single nucleotide polymorphism associated with nonsyndromic cleft palate influences the processing of miR-140

(2010) Ling Li et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Nonsyndromic cleft lip and palate: CRISPLD genes and the folate gene pathway connection

(2010) Brett T. Chiquet et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Mutations in BMP4 Are Associated with Subepithelial, Microform, and Overt Cleft Lip

(2009) Satoshi Suzuki et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Prdm16 is required for normal palatogenesis in mice

(2009) Bryan C. Bjork et al.   HUMAN MOLECULAR GENETICS

Cleft lip and palate

(2009) Peter A Mossey et al.   LANCET

Nested Case-Control Study of One-Carbon Metabolites in Mid-Pregnancy and Risks of Cleft Lip With and Without Cleft Palate

(2009) Gary M Shaw et al.   PEDIATRIC RESEARCH

Folate and Clefts of the Lip and Palate—A U.K.-Based Case-Control Study: Part I: Dietary and Supplemental Folate

(2008) J. Little et al.   CLEFT PALATE-CRANIOFACIAL JOURNAL

DNA Methylation Changes During Cleft Palate Formation Induced by Retinoic Acid in Mice

(2008) Motone Kuriyama et al.   CLEFT PALATE-CRANIOFACIAL JOURNAL

Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke

(2008) Alberto Izzotti et al.   FASEB JOURNAL

MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis

(2008) Johann K Eberhart et al.   NATURE GENETICS