Human lung fibroblasts produce proresolving peroxisome proliferator-activated receptor-γ ligands in a cyclooxygenase-2-dependent manner

Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice

(2016) Jennifer M. Dolan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inhibition of Neutrophil Extracellular Trap Formation after Stem Cell Transplant by Prostaglandin E2

(2016) Racquel Domingo-Gonzalez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Alveolar Epithelial Cell–Derived Prostaglandin E2Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation

(2016) Jennifer M. Speth et al.   JOURNAL OF IMMUNOLOGY

PGE2 -treated macrophages inhibit development of allergic lung inflammation in mice

(2016) Christina Draijer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Antifibrogenic Potential of PPARγ Ligands in Pulmonary Fibrosis

(2016) Patricia J. Sime   JOURNAL OF INVESTIGATIVE MEDICINE

Airway epithelial cell PPARγ modulates cigarette smoke-induced chemokine expression and emphysema susceptibility in mice

(2015) Siva Kumar Solleti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Thy1 (CD90) controls adipogenesis by regulating activity of the Src family kinase, Fyn

(2015) Collynn F. Woeller et al.   FASEB JOURNAL

Selenoprotein Expression in Macrophages Is Critical for Optimal Clearance of Parasitic HelminthNippostrongylus brasiliensis

(2015) Shakira M. Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of interleukin-1 beta (IL-1β) is a critical component of lung inflammation during influenza A (H1N1) virus infection

(2015) Kwang Seok Kim et al.   JOURNAL OF MEDICAL VIROLOGY

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

(2015) Charles N. Serhan et al.   SEMINARS IN IMMUNOLOGY

PPARγand the Innate Immune System Mediate the Resolution of Inflammation

(2015) Amanda Croasdell et al.   PPAR Research

Normal Human Lung Epithelial Cells Inhibit Transforming Growth Factor-β Induced Myofibroblast Differentiation via Prostaglandin E2

(2015) Amali P. Epa et al.   PLoS One

Refractory asthma: mechanisms, targets, and therapy

(2014) J. L. Trevor et al.   ALLERGY

Eicosanomic profiling reveals dominance of the epoxygenase pathway in human amniotic fluid at term in spontaneous labor

(2014) Krishna Rao Maddipati et al.   FASEB JOURNAL

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Prostaglandin E2Inhibits α-Smooth Muscle Actin Transcription during Myofibroblast Differentiation via Distinct Mechanisms of Modulation of Serum Response Factor and Myocardin-related Transcription Factor-A

(2014) Loka R. K. Penke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Agonistic induction of PPARγ reverses cigarette smoke–induced emphysema

(2014) Ming Shan et al.   JOURNAL OF CLINICAL INVESTIGATION

PPAR Gamma agonists regulate tobacco smoke-induced toll like receptor 4 expression in alveolar macrophages

(2014) Yan Yin et al.   RESPIRATORY RESEARCH

Lipid Mediators in the Resolution of Inflammation

(2014) Charles N. Serhan et al.   Cold Spring Harbor Perspectives in Biology

Human inflammatory and resolving lipid mediator responses to resistance exercise and ibuprofen treatment

(2013) James F. Markworth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

EP4 and EP2 Receptor Activation of Protein Kinase A by Prostaglandin E2Impairs Macrophage Phagocytosis ofClostridium sordellii

(2013) Lisa M. Rogers et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Resolution of Acute Inflammation in the Lung

(2013) Bruce D. Levy et al.   Annual Review of Physiology

Antifibrotic effect of atorvastatin on paraquat-induced pulmonary fibrosis: Role of PPARγ receptors

(2013) Hassan Malekinejad et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The effect of peroxisome proliferator-activated receptor-  ligands on in vitro and in vivo models of COPD

(2013) S. Lea et al.   EUROPEAN RESPIRATORY JOURNAL

Prostaglandin E2 suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells

(2013) Zbigniew Zasłona et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prostaglandin E2-Induced Changes in Alveolar Macrophage Scavenger Receptor Profiles Differentially Alter Phagocytosis of Pseudomonas aeruginosa and Staphylococcus aureus Post-Bone Marrow Transplant

(2013) R. Domingo-Gonzalez et al.   JOURNAL OF IMMUNOLOGY

Novel Biphasic Role of Resolvin D1 on Expression of Cyclooxygenase-2 in Lipopolysaccharide-Stimulated Lung Fibroblasts Is Partly through PI3K/AKT and ERK2 Pathways

(2013) Derong Wu et al.   MEDIATORS OF INFLAMMATION

A Novel Anti-Inflammatory and Pro-Resolving Role for Resolvin D1 in Acute Cigarette Smoke-Induced Lung Inflammation

(2013) Hsi-Min Hsiao et al.   PLoS One

Nontypeable Haemophilus Influenzae Infection Upregulates the NLRP3 Inflammasome and Leads to Caspase-1-Dependent Secretion of Interleukin-1β — A Possible Pathway of Exacerbations in COPD

(2013) Johannes Rotta detto Loria et al.   PLoS One

Novel Antiinflammatory Therapies for COPD

(2012) Nicholas J. Gross   CHEST

Resolution of Inflammation in Asthma

(2012) Bruce D. Levy et al.   CLINICS IN CHEST MEDICINE

E-prostanoid 2 receptor signaling suppresses lung innate immunity against Streptococcus pneumoniae

(2012) David M. Aronoff et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Prostaglandin E2 and Pain—An Update

(2011) Atsufumi Kawabata   BIOLOGICAL & PHARMACEUTICAL BULLETIN

PPAR-γ Ligands Repress TGFβ-Induced Myofibroblast Differentiation by Targeting the PI3K/Akt Pathway: Implications for Therapy of Fibrosis

(2011) Ajit A. Kulkarni et al.   PLoS One

Stability and analysis of eicosanoids and docosanoids in tissue culture media

(2011) Krishna Rao Maddipati et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Electrophilic PPARγ Ligands Attenuate IL-1β and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPARγ-Independent Mechanism

(2011) Christopher M. Hogan et al.   PPAR Research

Antenatally administered PPAR-γ agonist rosiglitazone prevents hyperoxia-induced neonatal rat lung injury

(2010) Virender K. Rehan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Regulation in chronic obstructive pulmonary disease: the role of regulatory T-cells and Th17 cells

(2010) Nina Lane et al.   CLINICAL SCIENCE

Peroxisome proliferator-activated receptor-γ ligands induce heme oxygenase-1 in lung fibroblasts by a PPARγ-independent, glutathione-dependent mechanism

(2009) Heather E. Ferguson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hyperoxia-induced neonatal rat lung injury involves activation of TGF-β and Wnt signaling and is protected by rosiglitazone

(2009) Chiranjib Dasgupta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Electrophilic Peroxisome Proliferator–Activated Receptor-γ Ligands Have Potent Antifibrotic Effects in Human Lung Fibroblasts

(2009) Heather E. Ferguson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Targeting PPAR receptors in the airway for the treatment of inflammatory lung disease

(2009) Maria G Belvisi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Deletion of PPAR  in Alveolar Macrophages Is Associated with a Th-1 Pulmonary Inflammatory Response

(2009) A. Malur et al.   JOURNAL OF IMMUNOLOGY

E-Prostanoid 3 Receptor Deletion Improves Pulmonary Host Defense and Protects Mice from Death in Severe Streptococcus pneumoniae Infection

(2009) D. M. Aronoff et al.   JOURNAL OF IMMUNOLOGY

Pathways connecting inflammation and cancer

(2008) Paola Allavena et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Peroxisome proliferator-activated receptors: a therapeutic target in COPD?

(2008) A. H. Remels et al.   EUROPEAN RESPIRATORY JOURNAL

The Aryl Hydrocarbon Receptor Attenuates Tobacco Smoke-induced Cyclooxygenase-2 and Prostaglandin Production in Lung Fibroblasts through Regulation of the NF-κB Family Member RelB

(2008) Carolyn J. Baglole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2and LXA4in the induction of macrophage death

(2008) Minjian Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Amelioration of pulmonary dysfunction and neutrophilic inflammation by PPARγ agonist in LPS-exposed guinea pigs

(2008) Rohini Sharma et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

The Role of PPAR in the Cyclooxygenase Pathway in Lung Cancer

(2008) Saswati Hazra et al.   PPAR Research

PPAR-γ agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis

(2007) Jami E. Milam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Rosiglitazone and 15-Deoxy-Δ12,14-Prostaglandin J2, PPARγ Agonists, Differentially Regulate Cigarette Smoke-Mediated Pro-Inflammatory Cytokine Release in Monocytes/Macrophages

(2007) Samuel Caito et al.   ANTIOXIDANTS & REDOX SIGNALING