Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation

NADPH Oxidase–Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment

(2015) Suvarthi Das et al.   AMERICAN JOURNAL OF PATHOLOGY

Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis

(2015) Diptadip Dattaroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Protective effects of Sparstolonin B, a selective TLR2 and TLR4 antagonist, on mouse endotoxin shock

(2015) Qiaoli Liang et al.   CYTOKINE

P2X7 Receptor as a Key Player in Oxidative Stress-Driven Cell Fate in Nonalcoholic Steatohepatitis

(2015) Saurabh Chatterjee et al.   Oxidative Medicine and Cellular Longevity

Sparstolonin B suppresses rat vascular smooth muscle cell proliferation, migration, inflammatory response and lipid accumulation

(2015) Qing Liu et al.   VASCULAR PHARMACOLOGY

Upregulation of miR21 and Repression of Grhl3 by Leptin Mediates Sinusoidal Endothelial Injury in Experimental Nonalcoholic Steatohepatitis

(2015) Sahar Pourhoseini et al.   PLoS One

Sparstolonin B Attenuates Hypoxia-Induced Apoptosis, Necrosis and Inflammation in Cultured Rat Left Ventricular Tissue Slices

(2014) Qing Liu et al.   CARDIOVASCULAR DRUGS AND THERAPY

GM-CSF Production by Tumor Cells Is Associated with Improved Survival in Colorectal Cancer

(2014) C. A. Nebiker et al.   CLINICAL CANCER RESEARCH

High-mobility group box 1 exacerbates CCl4-induced acute liver injury in mice

(2014) Maojian Chen et al.   CLINICAL IMMUNOLOGY

The Inflammasome in Liver Injury and Non-Alcoholic Fatty Liver Disease

(2014) Wajahat Zafar Mehal   DIGESTIVE DISEASES

Sparstolonin B attenuates hypoxia–reoxygenation-induced cardiomyocyte inflammation

(2014) Qing Liu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Sparstolonin B, a Novel Plant Derived Compound, Arrests Cell Cycle and Induces Apoptosis in N-Myc Amplified and N-Myc Nonamplified Neuroblastoma Cells

(2014) Ambrish Kumar et al.   PLoS One

Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease

(2014) Kouichi Miura   WORLD JOURNAL OF GASTROENTEROLOGY

Role of NADPH Oxidases in Liver Fibrosis

(2013) Yong-Han Paik et al.   ANTIOXIDANTS & REDOX SIGNALING

Sparstolonin B suppresses lipopolysaccharide-induced inflammation in human umbilical vein endothelial cells

(2013) Qiaoli Liang et al.   ARCHIVES OF PHARMACAL RESEARCH

Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis

(2013) Yoon Seok Roh et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Leptin up-regulates TLR2 in human monocytes

(2013) Katrin M. Jaedicke et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pharmacological agents for NASH

(2013) Vlad Ratziu   Nature Reviews Gastroenterology & Hepatology

Sparstolonin B Inhibits Pro-Angiogenic Functions and Blocks Cell Cycle Progression in Endothelial Cells

(2013) Henry R. Bateman et al.   PLoS One

Environmental Toxin–Linked Nonalcoholic Steatohepatitis and Hepatic Metabolic Reprogramming in Obese Mice

(2013) Ratanesh Kumar Seth et al.   TOXICOLOGICAL SCIENCES

Effects of probiotics on nonalcoholic fatty liver disease: A meta-analysis

(2013) Yan-Yan Ma   WORLD JOURNAL OF GASTROENTEROLOGY

Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling

(2012) Kento Imajo et al.   Cell Metabolism

Selective Insulin and Leptin Resistance in Metabolic Disorders

(2012) A. Christine Könner et al.   Cell Metabolism

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

(2012) Kosei Eguchi et al.   Cell Metabolism

Mechanisms of Disease Progression in NASH

(2012) Brittany N. Bohinc et al.   Clinics in Liver Disease

A Myriad of Pathways to NASH

(2012) Soledad Larrain et al.   Clinics in Liver Disease

Vitamin E and nonalcoholic fatty liver disease

(2012) Tommy Pacana et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Clinical Spectrum and Therapy of Non-Alcoholic Steatohepatitis

(2012) Christopher Paul Day   DIGESTIVE DISEASES

Innate Immune Reactivity of the Ileum–Liver Axis in Nonalcoholic Steatohepatitis

(2012) Tatsuhiro Tsujimoto et al.   DIGESTIVE DISEASES AND SCIENCES

Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice

(2012) Dewei Ye et al.   GUT

Atorvastatin protects obese mice against hepatic ischemia-reperfusion injury by Toll-like receptor-4 suppression and endothelial nitric oxide synthase activation

(2012) Hussam Ajamieh et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis

(2012) Saurabh Chatterjee et al.   JOURNAL OF HEPATOLOGY

Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model

(2012) Ze Zheng et al.   JOURNAL OF HEPATOLOGY

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Physical activity: an essential component of lifestyle modification in NAFLD

(2012) Benjamin Rodriguez et al.   Nature Reviews Gastroenterology & Hepatology

Sinusoidal Endothelial Dysfunction Precedes Inflammation and Fibrosis in a Model of NAFLD

(2012) Marcos Pasarín et al.   PLoS One

Leaky gut and the liver: A role for bacterial translocation in nonalcoholic steatohepatitis

(2012) Yaron Ilan   WORLD JOURNAL OF GASTROENTEROLOGY

Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice

(2011) Timea Csak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists

(2011) Francesco Peri et al.   BIOTECHNOLOGY ADVANCES

Toll-like receptor 4-dependent Kupffer cell activation and liver injury in a novel mouse model of parenteral nutrition and intestinal injury

(2011) Karim C. El Kasmi et al.   HEPATOLOGY

Characterization of Sparstolonin B, a Chinese Herb-derived Compound, as a Selective Toll-like Receptor Antagonist with Potent Anti-inflammatory Properties

(2011) Qiaoli Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gut Microbiota, Intestinal Permeability, Obesity-Induced Inflammation, and Liver Injury

(2011) Thomas H. Frazier et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Peroxynitrite induces HMGB1 release by cardiac cells in vitro and HMGB1 upregulation in the infarcted myocardium in vivo

(2010) N. Loukili et al.   CARDIOVASCULAR RESEARCH

Status of bacterial colonization, Toll-like receptor expression and nuclear factor-kappa B activation in normal and diseased human livers

(2010) Rashmi Singh et al.   CLINICAL IMMUNOLOGY

Small Intestinal Bacterial Overgrowth in Nonalcoholic Steatohepatitis: Association with Toll-Like Receptor 4 Expression and Plasma Levels of Interleukin 8

(2010) Ahmed Abu Shanab et al.   DIGESTIVE DISEASES AND SCIENCES

Progression of Alcoholic and Non-alcoholic Steatohepatitis: Common Metabolic Aspects of Innate Immune System and Oxidative Stress

(2010) Shuhei Sakaguchi et al.   Drug Metabolism and Pharmacokinetics

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis

(2010) Ashkan Farhadi et al.   LIVER INTERNATIONAL

Nonalcoholic fatty liver disease: A manifestation of the metabolic syndrome

(2009) C. H. KIM et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Kupffer Cells Mediate Leptin-Induced Liver Fibrosis

(2009) Jianhua Wang et al.   GASTROENTEROLOGY

VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice

(2009) Arumugam Velayudham et al.   HEPATOLOGY

Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner

(2009) Scott W. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

(2009) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

The gut–liver-axis: Endotoxemia, inflammation, insulin resistance and NASH

(2008) Jürgen Siebler et al.   JOURNAL OF HEPATOLOGY