Article
Microbiology
Jawad Alharake, Frederique Bidard, Thiziri Aouam, Catherine Senamaud-Beaufort, Antoine Margeot, Senta Heiss-Blanquet
Summary: The transcription factor RES2 in the T. reesei Rut-C30 strain contributes to higher protein secretion by adjusting the expression of genes involved in different steps of protein synthesis and the secretion pathway.
Article
Biochemistry & Molecular Biology
Prathyush Pothukuchi, Ilenia Agliarulo, Marinella Pirozzi, Riccardo Rizzo, Domenico Russo, Gabriele Turacchio, Julian Nuechel, Jia-Shu Yang, Charlotte Gehin, Laura Capolupo, Maria Jose Hernandez-Corbacho, Ansuman Biswas, Giovanna Vanacore, Nina Dathan, Takahiro Nitta, Petra Henklein, Mukund Thattai, Jin-Ichi Inokuchi, Victor W. Hsu, Markus Plomann, Lina M. Obeid, Yusuf A. Hannun, Alberto Luini, Giovanni D'Angelo, Seetharaman Parashuraman
Summary: The Golgi matrix protein GRASP55 plays a crucial role in regulating the compartmentalized localization of key enzymes involved in glycosphingolipid biosynthesis. Lack of GRASP55 or expression of mutant enzymes without GRASP55 binding sites can affect the synthesis of glycosphingolipids by altering metabolic flux.
Article
Multidisciplinary Sciences
Swarna L. Vijayaraj, Rebecca Feltham, Maryam Rashidi, Daniel Frank, Zhengyang Liu, Daniel S. Simpson, Gregor Ebert, Angelina Vince, Marco J. Herold, Andrew Kueh, Jaclyn S. Pearson, Laura F. Dagley, James M. Murphy, Andrew I. Webb, Kate E. Lawlor, James E. Vince
Summary: IL-1β is regulated by ubiquitination to prevent excessive activity, reducing inflammation and potential immunopathological damage.
NATURE COMMUNICATIONS
(2021)
Article
Hematology
Wuwei Rong, Chenchen Liu, Xiaoming Li, Naifu Wan, Lijiang Wei, Wentong Zhu, Peiyuan Bai, Ming Li, Yangjing Ou, Fang Li, Lingxia Wang, Xuanhui Wu, Jianling Liu, Mingyan Xing, Xiaoming Zhao, Han Liu, Haibing Zhang, Ankang Lyu
Summary: This study reveals the role of caspase-8 in regulating IL-1 beta activation in macrophages and its involvement in pulmonary arterial hypertension (PAH). Caspase-8 promotes inflammatory cell infiltration and pulmonary arterial smooth muscle cell proliferation via NLRP3/IL-1 beta activation, contributing to the pathogenesis of PAH.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Review
Cell Biology
Barry J. Laird, Donald McMillan, Richard J. E. Skipworth, Marie T. Fallon, D. Robert Paval, Iain McNeish, Iain J. Gallagher
Summary: Treatment of cancer cachexia is still an unmet need, with recent trials showing a potential role for targeting IL-1 beta using monoclonal antibody canakinumab in lung cancer. The neuroinflammation mediated by IL-1 beta plays a critical role in cachexia development, leading to muscle proteolysis and adipose lipolysis, but the precise mechanism of targeting IL-1 beta in treating cachexia remains unclear.
Article
Engineering, Environmental
Ramesh Kumawat, Raghuvir Singh Tomar
Summary: Heavy metal pollution is a severe environmental problem that adversely affects human health. This study shows that the Tup1-Cyc8 complex plays a crucial role in activating genes involved in mitigating oxidative and endoplasmic reticulum stress during heavy metal exposure.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Multidisciplinary Sciences
Hae-Ri Lee, Young-Jin Jeong, Joong-Woon Lee, JooYeon Jhun, Hyun Sik Na, Keun-Hyung Cho, Seok Jung Kim, Mi-La Cho, Tae-Hwe Heo
Summary: The study revealed that tannic acid (TA) inhibits IL-1 beta-induced inflammation and matrix degradation in human OA chondrocytes by blocking IL-1 beta-IL-1R1 interaction. In addition, TA showed protective effects in a rat OA model by reducing pain, cartilage degradation, and IL-1 beta-mediated inflammation.
Article
Immunology
Andrea Borrego, Francesca Colombo, Jean Gabriel de Souza, Jose Ricardo Jensen, Alice Dassano, Rocco Piazza, Barbara Anais Rodrigues dos Santos, Orlando Garcia Ribeiro, Marcelo De Franco, Wafa Hanna Koury Cabrera, Marcelo Yudi Icimoto, Nancy Starobinas, Geraldo Magalhaes, Leticia Figueiredo Monteleone, Silas Fernandes Eto, Carlos DeOcesano-Pereira, Mauricio Barbugiani Goldfeder, Kerly Fernanda Mesquita Pasqualoto, Tommaso A. Dragani, Olga Celia Martinez Ibanez
Summary: We identified Pycard and BC017158 genes as potential effectors of a Quantitative Trait locus (QTL) on chromosome 7, controlling acute inflammatory response and IL-1 beta production. A mutation in ASC protein was found to play a crucial role in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Jun Zhang, Nirmal Veeramachaneni
Summary: Inflammation is a process that protects organs and enables repair, but dysregulated inflammation leads to diseases like cancer. Cancer-related inflammation modulates the tumor microenvironment, an important factor in tumor progression, and targeting its immune component is the basis of immunotherapy. Blocking interleukin-1 beta has shown promise in reducing the incidence of lung cancer, opening up a new avenue for lung cancer therapy.
BIOMARKER RESEARCH
(2022)
Review
Cell Biology
Yalan Jiang, Zehua Tao, Hua Chen, Sheng Xia
Summary: The endoplasmic reticulum quality control system plays a crucial role in immune cells, maintaining protein homeostasis and ensuring normal development and function of immune cells. Imbalance in ER homeostasis may impact immune responses, suggesting new therapeutic targets for immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hend Alfadul, Shaun Sabico, Mohammed G. A. Ansari, Abdullah M. Alnaami, Osama E. Amer, Syed D. Hussain, Kaiser Wani, Malak N. K. Khattak, Mario Clerici, Nasser M. Al-Daghri
Summary: Inflammasome activation of NLRP3 is involved in the pathogenesis of inflammatory diseases. Limited studies have reported the associations between NLRP3 levels or other circulating interleukins and glycemic status. This study investigated the differences and associations between serum levels of NLRP3 and ILs in Arab adults with prediabetes and type 2 diabetes mellitus.
Article
Cardiac & Cardiovascular Systems
Jan Hettwer, Julia Hinterdobler, Benedikt Miritsch, Marcus-Andre Deutsch, Xinghai Li, Carina Mauersberger, Aldo Moggio, Quinte Braster, Hermann Gram, Avril A. B. Robertson, Matthew A. Cooper, Olaf Gross, Markus Krane, Christian Weber, Wolfgang Koenig, Oliver Soehnlein, Nicholas H. Adamstein, Paul Ridker, Heribert Schunkert, Peter Libby, Thorsten Kessler, Hendrik B. Sager
Summary: This study investigates the mechanisms of IL-1 beta-targeted therapies and finds that anti-IL-1 beta treatment and NLRP3-inflammasome inhibition can reduce vascular inflammation and progression of atherosclerosis through decreased supply and uptake of inflammatory leucocytes in the blood.
CARDIOVASCULAR RESEARCH
(2022)
Review
Immunology
Yang Li, Qianzhou Jiang
Summary: Inflammasomes are supramolecular platforms that respond to damage-associated and pathogen-associated patterns, activating caspases and leading to pyroptosis and cytokine secretion. The uncoupling preferences between pyroptosis and cytokine secretion have context-dependent effects and contribute to various pathological conditions. Precise coupling and uncoupling decisions are crucial for tissue repair and threat elimination.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Microbiology
Manal H. Alshareef, Elizabeth L. Hartland, Kathleen McCaffrey
Summary: The unfolded protein response (UPR) is a homeostatic response to endoplasmic reticulum (ER) stress within eukaryotic cells. It plays a crucial role in host defense against bacterial infection, but UPR-mediated apoptosis can also contribute to tissue damage and disease.
Article
Immunology
Masashi Mizuno, Rei Nakano, Saki Nose, Moeka Matsumura, Yasuyuki Nii, Kentaro Kurogochi, Hiroshi Sugiya, Masami Uechi
Summary: In this study, it was found that interleukin 1 beta (IL-1 beta) induces the expression of interleukin 8 (IL-8) in canine cardiac fibroblasts through the activation of nuclear factor (NF)-kappa B p65.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Advait Subramanian, Anita Capalbo, Namrata Ravi Iyengar, Riccardo Rizzo, Antonella di Campli, Rosaria Di Martino, Matteo Lo Monte, Andrea R. Beccari, Amol Yerudkar, Carmen del Vecchio, Luigi Glielmo, Gabriele Turacchio, Marinella Pirozzi, Sang Geon Kim, Petra Henklein, Jorge Cancino, Seetharaman Parashuraman, Dario Diviani, Francesca Fanelli, Michele Sallese, Alberto Luini
Article
Cell Biology
Roxana-Olimpia Gheorghe, Alexandru Deftu, Alexandru Filippi, Andreea Grosu, Melania Bica-Popi, Marioara Chiritoiu, Gabriela Chiritoiu, Cristian Munteanu, Luigi Silvestro, Violeta Ristoiu
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2020)
Article
Cell Biology
Benjamin J. Swartzwelter, Francesco Barbero, Alessandro Verde, Maria Mangini, Marinella Pirozzi, Anna Chiara De Luca, Victor F. Puntes, Luciana C. C. Leite, Paola Italiani, Diana Boraschi
Article
Agriculture, Dairy & Animal Science
Antonio Di Loria, Vincenzo Dattilo, Domenico Santoro, Jacopo Guccione, Adriana De Luca, Paolo Ciaramella, Marinella Pirozzi, Enrico Iaccino
Article
Biochemistry & Molecular Biology
Marioara Chiritoiu, Gabriela N. Chiritoiu, Cristian V. A. Munteanu, Florin Pastrama, N. Erwin Ivessa, Stefana M. Petrescu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Polymer Science
Anita Ioana Visan, Gianina Popescu-Pelin, Oana Gherasim, Andreea Mihailescu, Marcela Socol, Irina Zgura, Mari Chiritoiu, Livia Elena Sima, Felicia Antohe, Luminita Ivan, Diana M. Vranceanu, Cosmin M. Cotrut, Rodica Cristescu, Gabriel Socol
Review
Medicine, Research & Experimental
Gheorghita Isvoranu, Mihaela Surcel, Adriana Narcisa Munteanu, Ovidiu Gabriel Bratu, Florentina Ionita-Radu, Monica Teodora Neagu, Marioara Chiritoiu-Butnaru
Summary: IL-15 is a promising candidate for cancer immunotherapy, as it enhances antitumor responses by promoting the activation of T cells, B cells, and NK cells.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Prathyush Pothukuchi, Ilenia Agliarulo, Marinella Pirozzi, Riccardo Rizzo, Domenico Russo, Gabriele Turacchio, Julian Nuechel, Jia-Shu Yang, Charlotte Gehin, Laura Capolupo, Maria Jose Hernandez-Corbacho, Ansuman Biswas, Giovanna Vanacore, Nina Dathan, Takahiro Nitta, Petra Henklein, Mukund Thattai, Jin-Ichi Inokuchi, Victor W. Hsu, Markus Plomann, Lina M. Obeid, Yusuf A. Hannun, Alberto Luini, Giovanni D'Angelo, Seetharaman Parashuraman
Summary: The Golgi matrix protein GRASP55 plays a crucial role in regulating the compartmentalized localization of key enzymes involved in glycosphingolipid biosynthesis. Lack of GRASP55 or expression of mutant enzymes without GRASP55 binding sites can affect the synthesis of glycosphingolipids by altering metabolic flux.
Article
Biochemistry & Molecular Biology
Chiara Tramontano, Bruno Miranda, Giovanna Chianese, Luca De Stefano, Carlo Forestiere, Marinella Pirozzi, Ilaria Rea
Summary: This study combined inorganic diatomite nanoparticles with gelatin-stabilized gold nanoparticles to develop an optical platform for drug delivery. By increasing the thickness of the gelatin shells, the drug loading capacity was improved. Optical modeling was used to monitor drug release processes and proved to be an efficient tool for designing polymer-coated nanocarriers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Giovanna Grimaldi, Angela Filograna, Laura Schembri, Matteo Lo Monte, Rosaria Di Martino, Marinella Pirozzi, Daniela Spano, Andrea R. Beccari, Seetharaman Parashuraman, Alberto Luini, Carmen Valente, Daniela Corda
Summary: This study reveals that the mono-ADP-ribosylation of Golgin-97 by PARP12 selectively regulates the transport of specific basolateral proteins, contributing to the maintenance of cell polarity and cell-cell junctions. The enzymatic activity of PARP12 depends on the activation of protein kinase D, which is essential for its catalytic activity and involvement in the basolateral transport pathway.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Genetics & Heredity
Simona Ghenea, Marioara Chiritoiu, Robi Tacutu, Antonio Miranda-Vizuete, Stefana Maria Petrescu
Summary: This study investigates the role of EDEM proteins in ER stress response and reveals that they have a broader function than previously recognized. The findings provide insights into the regulation of ER stress and have implications for clinical and therapeutic investigations.
Article
Multidisciplinary Sciences
Gabriela N. Chiritoiu, Marioara Chiritoiu, Cristian V. A. Munteanu
Summary: This research focuses on the role of EDEM2 in protein selection and degradation, utilizing various proteomics techniques to identify associated proteins and potential substrates. The study verified the findings through biochemical experiments and validated datasets published in Molecular and Cellular Proteomics.
Editorial Material
Cell Biology
Marioara Chiritoiu-Butnaru, Sarah E. E. Stewart, Min Zhang, Vivek Malhotra, Julien Villeneuve
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemical Research Methods
Cristian V. A. Munteanu, Gabriela N. Chiritoiu, Marioara Chiritoiu, Simona Ghenea, Andrei-Jose Petrescu, Stefana M. Petrescu
Summary: The study demonstrates the critical role of EDEM2 in ER homeostasis and its association with cancer progression. By identifying EDEM2 glyco clients and associated proteins, it sheds light on the link between ER homeostasis and cancer progression.
MOLECULAR & CELLULAR PROTEOMICS
(2021)
Article
Multidisciplinary Sciences
Raluca M. Boteanu, Viorel I. Suica, Luminita Ivan, Florentina Safciuc, Elena Uyy, Emanuel Dragan, Sorin M. Croitoru, Valentina Grumezescu, Marioara Chiritoiu, Livia E. Sima, Constantin Vlagioiu, Gabriel Socol, Felicia Antohe
SCIENTIFIC REPORTS
(2020)
