The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation
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Title
The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation
Authors
Keywords
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Journal
Nature Communications
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-05-11
DOI
10.1038/s41467-021-22979-3
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Note: Only part of the references are listed.- RIP-roaring inflammation: RIPK1 and RIPK3 driven NLRP3 inflammasome activation and autoinflammatory disease
- (2020) Mary Speir et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Inflammasomes and Cell Death: Common Pathways in Microparticle Diseases
- (2020) Maryam Rashidi et al. TRENDS IN MOLECULAR MEDICINE
- ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination
- (2019) Guangming Ren et al. EMBO JOURNAL
- Inflammasomes in neuroinflammatory and neurodegenerative diseases
- (2019) Sofie Voet et al. EMBO Molecular Medicine
- Control of the inflammasome by the ubiquitin system
- (2019) Gloria Lopez‐Castejon FEBS Journal
- SUMO1 SUMOylates and SENP3 deSUMOylates NLRP3 to orchestrate the inflammasome activation
- (2019) Luyao Shao et al. FASEB JOURNAL
- The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages
- (2018) Charles L. Evavold et al. IMMUNITY
- Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
- (2018) Dave Boucher et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1β Secretion
- (2018) Kaiwen W. Chen et al. JOURNAL OF IMMUNOLOGY
- K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains
- (2018) Fumiaki Ohtake et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SUMO-mediated regulation of NLRP3 modulates inflammasome activity
- (2018) Rachael Barry et al. Nature Communications
- Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion
- (2018) Mercedes Monteleone et al. Cell Reports
- Stressing out the mitochondria: Mechanistic insights into NLRP3 inflammasome activation
- (2018) Monica Yabal et al. JOURNAL OF LEUKOCYTE BIOLOGY
- POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity
- (2018) Li Zhang et al. Nature Communications
- Regulation of NLRP3 Inflammasome by Phosphorylation
- (2018) Nan Song et al. Frontiers in Immunology
- Posttranslational Modification as a Critical Determinant of Cytoplasmic Innate Immune Recognition
- (2017) Paul J. Baker et al. PHYSIOLOGICAL REVIEWS
- The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1β Secretion by Inflammasomes
- (2017) Matthew J.G. Eldridge et al. Cell Reports
- Protein post-translational modifications: In silico prediction tools and molecular modeling
- (2017) Martina Audagnotto et al. Computational and Structural Biotechnology Journal
- Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion
- (2016) S A Conos et al. CELL DEATH AND DIFFERENTIATION
- Ubiquitin modifications
- (2016) Kirby N Swatek et al. CELL RESEARCH
- Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
- (2016) Xing Liu et al. NATURE
- Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation
- (2016) Seth L. Masters et al. Science Translational Medicine
- Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis
- (2016) Mary Speir et al. Nature Microbiology
- Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
- (2015) Wan-ting He et al. CELL RESEARCH
- Mechanisms of unconventional secretion of IL-1 family cytokines
- (2015) Mercedes Monteleone et al. CYTOKINE
- A20 Restricts Ubiquitination of Pro-Interleukin-1β Protein Complexes and Suppresses NLRP3 Inflammasome Activity
- (2015) Bao H. Duong et al. IMMUNITY
- Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme
- (2015) Inna S. Afonina et al. IMMUNITY
- Chaperone-mediated 26S Proteasome Remodeling Facilitates Free K63 Ubiquitin Chain Production and Aggresome Clearance
- (2015) Priyaanka Nanduri et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibiting the Inflammasome: A Chemical Perspective
- (2015) Alex G. Baldwin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
- (2015) Nobuhiko Kayagaki et al. NATURE
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
- (2015) Qing Zhou et al. NATURE GENETICS
- RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
- (2015) Kate E. Lawlor et al. Nature Communications
- The Proteasome Distinguishes between Heterotypic and Homotypic Lysine-11-Linked Polyubiquitin Chains
- (2015) Guinevere L. Grice et al. Cell Reports
- Dendritic Cell IL-1α and IL-1β Are Polyubiquitinated and Degraded by the Proteasome
- (2014) Joseph S. Ainscough et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lysosomes Integrate Metabolic-Inflammatory Cross-talk in Primary Macrophage Inflammasome Activation
- (2014) Kassandra Weber et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis
- (2014) Lieselotte Vande Walle et al. NATURE
- The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge
- (2014) Kaiwen W. Chen et al. Cell Reports
- Granzyme A Produces Bioactive IL-1β through a Nonapoptotic Inflammasome-Independent Pathway
- (2014) Dagmar Hildebrand et al. Cell Reports
- Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1 via Caspase-8 in Dendritic Cells
- (2013) C. Antonopoulos et al. JOURNAL OF IMMUNOLOGY
- Proteasomes Activate Aggresome Disassembly and Clearance by Producing Unanchored Ubiquitin Chains
- (2013) Rui Hao et al. MOLECULAR CELL
- Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation
- (2012) James E. Vince et al. IMMUNITY
- Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1 and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner
- (2012) L. Bossaller et al. JOURNAL OF IMMUNOLOGY
- Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity
- (2012) Bénédicte F. Py et al. MOLECULAR CELL
- Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
- (2012) Chong-Shan Shi et al. NATURE IMMUNOLOGY
- Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
- (2012) Charles A. Dinarello et al. NATURE REVIEWS DRUG DISCOVERY
- The NLRP3 inflammasome in health and disease: the good, the bad and the ugly
- (2011) P. Menu et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment
- (2011) Jürgen Cox et al. JOURNAL OF PROTEOME RESEARCH
- The Inflammasomes
- (2010) Kate Schroder et al. CELL
- Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation
- (2009) Ping Xu et al. CELL
- Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome
- (2009) Yasushi Saeki et al. EMBO JOURNAL
- Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20
- (2008) Emre E. Turer et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8
- (2008) Jonathan Maelfait et al. JOURNAL OF EXPERIMENTAL MEDICINE
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