Ion channelopathies in functional GI disorders

Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces

(2016) Fan Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

(2016) Jeremiah D. Osteen et al.   NATURE

Diagnosis and management of chronic constipation in adults

(2016) Satish S. C. Rao et al.   Nature Reviews Gastroenterology & Hepatology

Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells

(2015) Leila Neshatian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Alternative Paradigms for Ion Channelopathies: Disorders of Ion Channel Membrane Trafficking and Posttranslational Modification

(2015) Jerry Curran et al.   Annual Review of Physiology

Gastrointestinal Manifestations of Cystic Fibrosis

(2015) Thomas Kelly et al.   DIGESTIVE DISEASES AND SCIENCES

677 IBS Patients Have SCN5A Mutations That Result in Decreased NaV1.5 Current and Mechanosensitivity

(2015) Leila Neshatian et al.   GASTROENTEROLOGY

Expression and function of theScn5a-encoded voltage-gated sodium channel NaV1.5 in the rat jejunum

(2015) A. Beyder et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The voltage-gated sodium channel NaV1.9 in visceral pain

(2015) J. R. F. Hockley et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The role of theSCN5A-encoded channelopathy in irritable bowel syndrome and other gastrointestinal disorders

(2015) T. E. Verstraelen et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Gain-of-function mutations in sodium channel NaV1.9 in painful neuropathy

(2014) Jianying Huang et al.   BRAIN

Loss-of-Function of the Voltage-Gated Sodium Channel NaV1.5 (Channelopathies) in Patients With Irritable Bowel Syndrome

(2014) Arthur Beyder et al.   GASTROENTEROLOGY

Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts

(2014) Weronica E Ek et al.   GUT

Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease–derived stimuli

(2014) James R.F. Hockley et al.   PAIN

A de novo gain-of-function mutation in SCN11A causes loss of pain perception

(2013) Enrico Leipold et al.   NATURE GENETICS

Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

(2013) Gary M. Mawe et al.   Nature Reviews Gastroenterology & Hepatology

Genes and functional GI disorders: from casual to causal relationship

(2013) Mauro D'Amato   NEUROGASTROENTEROLOGY AND MOTILITY

Ion Channels as Therapeutic Targets: A Drug Discovery Perspective

(2012) Sharan K. Bagal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Familial Diarrhea Syndrome Caused by an ActivatingGUCY2CMutation

(2012) Torunn Fiskerstrand et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Relationship Between Gastric Myoelectric Activity and Mutation Suggesting Sodium Channelopathy in Patients With Brugada Syndrome and Functional Dyspepsia - A Pilot Study

(2012) Kyo Tae Jung et al.   Journal of Neurogastroenterology and Motility

Altered Expression of Ano1 Variants in Human Diabetic Gastroparesis

(2011) Amelia Mazzone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantification of gastrointestinal sodium channelopathy

(2011) Yong Cheng Poh et al.   JOURNAL OF THEORETICAL BIOLOGY

Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels

(2011) Stephan A. Pless et al.   Nature Communications

Targeting ion channels for the treatment of gastrointestinal motility disorders

(2011) Arthur Beyder et al.   Therapeutic Advances in Gastroenterology

Genetic Approaches to Functional Gastrointestinal Disorders

(2010) Yuri A. Saito et al.   GASTROENTEROLOGY

Pain as a channelopathy

(2010) Ramin Raouf et al.   JOURNAL OF CLINICAL INVESTIGATION

Paroxysmal extreme pain disorder: a molecular lesion of peripheral neurons

(2010) Jin-Sung Choi et al.   Nature Reviews Neurology

Effect of VX-770 in Persons with Cystic Fibrosis and the G551D-CFTRMutation

(2010) Frank J. Accurso et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pain perception is altered by a nucleotide polymorphism in SCN9A

(2010) F. Reimann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis of mechanosensitivity

(2009) Stuart M. Brierley   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Cardiac sodium channel Nav1.5 and interacting proteins: Physiology and pathophysiology

(2009) Hugues Abriel   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sodium channel mutation in irritable bowel syndrome: evidence for an ion channelopathy

(2008) Yuri A. Saito et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome

(2008) Johannes Kapeller et al.   HUMAN MOLECULAR GENETICS

A Mutation in Telethonin Alters Nav1.5 Function

(2008) Amelia Mazzone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paroxysmal Extreme Pain Disorder M1627K Mutation in Human Nav1.7 Renders DRG Neurons Hyperexcitable

(2008) Sulayman D Dib-Hajj et al.   Molecular Pain

Development of drugs for gastrointestinal motor disorders: translating science to clinical need

(2008) g. j. sanger et al.   NEUROGASTROENTEROLOGY AND MOTILITY