Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes

Unraveling the CNOT: A new player in the autophagy–cell death nexus

(2018) Saumya Das   Science Signaling

Unraveling the CNOT: A new player in the autophagy–cell death nexus

(2018) Saumya Das   Science Signaling

Ductular reaction in liver diseases: pathological mechanisms and translational significances

(2018) Keisaku Sato et al.   HEPATOLOGY

Adipocyte-specific disruption of mouseCnot3causes lipodystrophy

(2017) Xue Li et al.   FEBS LETTERS

DND1 maintains germline stem cells via recruitment of the CCR4–NOT complex to target mRNAs

(2017) Masashi Yamaji et al.   NATURE

Coordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expression

(2016) Suzan Ruijtenberg et al.   CELL CYCLE

MicroRNA-122 regulates polyploidization in the murine liver

(2016) Shu-hao Hsu et al.   HEPATOLOGY

Regulation of hepatocyte identity and quiescence

(2015) Carmen Berasain et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Orchestrating liver development

(2015) M. Gordillo et al.   DEVELOPMENT

CNOT3 contributes to early B cell development by controllingIghrearrangement andp53mRNA stability

(2015) Takeshi Inoue et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Post-transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity

(2015) Akinori Takahashi et al.   Cell Reports

Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy

(2014) Marcelo A. Mori et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNAs Trigger Dissociation of eIF4AI and eIF4AII from Target mRNAs in Humans

(2014) Akira Fukao et al.   MOLECULAR CELL

ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK–RSK pathway

(2014) Shungo Adachi et al.   NUCLEIC ACIDS RESEARCH

A Mutation in cnot8, Component of the Ccr4-Not Complex Regulating Transcript Stability, Affects Expression Levels of Developmental Regulators and Reveals a Role of Fgf3 in Development of Caudal Hypothalamic Dopaminergic Neurons

(2014) Peter Koch et al.   PLoS One

Stability of mRNA influences osteoporotic bone mass via CNOT3

(2014) C. Watanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs shape circadian hepatic gene expression on a transcriptome-wide scale

(2014) Ngoc-Hien Du et al.   eLife

Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by tristetraprolin

(2013) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Involvement of CNOT3 in mitotic progression through inhibition of MAD1 expression

(2012) Akinori Takahashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deadenylation of cytoplasmic mRNA by the mammalian Ccr4–Not complex

(2012) Rachel Doidge et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Hepcidin and iron homeostasis

(2012) Tomas Ganz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver

(2012) Shu-hao Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis

(2012) Wei-Chih Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets

(2012) Eric Huntzinger et al.   NUCLEIC ACIDS RESEARCH

Transcriptome Comparison between Fetal and Adult Mouse Livers: Implications for Circadian Clock Mechanisms

(2012) Chengwei Li et al.   PLoS One

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

Coordinate regulation of mRNA decay networks by GU-rich elements and CELF1

(2011) Irina Vlasova-St. Louis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Obesity resistance and increased hepatic expression of catabolism-related mRNAs inCnot3+/−mice

(2011) Masahiro Morita et al.   EMBO JOURNAL

A Feedback Loop Between the Liver-Enriched Transcription Factor Network and Mir-122 Controls Hepatocyte Differentiation

(2011) Ilaria Laudadio et al.   GASTROENTEROLOGY

The Ccr4–Not complex

(2011) Martine A. Collart et al.   GENE

CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death

(2011) Kentaro Ito et al.   GENES TO CELLS

Liver stem/progenitor cells: their characteristics and regulatory mechanisms

(2011) M. Tanaka et al.   JOURNAL OF BIOCHEMISTRY

The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4–Not complex contribute to the prevention of cell death and senescence

(2011) Saloni Mittal et al.   MOLECULAR BIOLOGY OF THE CELL

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4–NOT

(2011) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miRNA repression involves GW182-mediated recruitment of CCR4–NOT through conserved W-containing motifs

(2011) Marina Chekulaeva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Zhx2 and Zbtb20: Novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer

(2011) Martha L. Peterson et al.   SEMINARS IN CANCER BIOLOGY

Pause locally, splice globally

(2011) Fernando Carrillo Oesterreich et al.   TRENDS IN CELL BIOLOGY

A Global In Vivo Drosophila RNAi Screen Identifies NOT3 as a Conserved Regulator of Heart Function

(2010) G. Gregory Neely et al.   CELL

Klf6/copeb is required for hepatic outgrowth in zebrafish and for hepatocyte specification in mouse ES cells

(2010) Xiao Zhao et al.   DEVELOPMENTAL BIOLOGY

Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells

(2009) Shinya Ohata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Disruption of Dicer1 Induces Dysregulated Fetal Gene Expression and Promotes Hepatocarcinogenesis

(2009) Shigeki Sekine et al.   GASTROENTEROLOGY

A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal

(2009) G. Hu et al.   GENES & DEVELOPMENT

Mouse hepatoblasts at distinct developmental stages are characterized by expression of EpCAM and DLK1: Drastic change of EpCAM expression during liver development

(2009) Minoru Tanaka et al.   MECHANISMS OF DEVELOPMENT

The Silencing Domain of GW182 Interacts with PABPC1 To Promote Translational Repression and Degradation of MicroRNA Targets and Is Required for Target Release

(2009) L. Zekri et al.   MOLECULAR AND CELLULAR BIOLOGY

The Ccr4–Not Deadenylase Subunits CNOT7 and CNOT8 Have Overlapping Roles and Modulate Cell Proliferation

(2009) Akhmed Aslam et al.   MOLECULAR BIOLOGY OF THE CELL

Rates of in situ transcription and splicing in large human genes

(2009) Jarnail Singh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dicer Ablation Affects Antibody Diversity and Cell Survival in the B Lymphocyte Lineage

(2008) Sergei B. Koralov et al.   CELL

A deadenylation negative feedback mechanism governs meiotic metaphase arrest

(2008) Eulàlia Belloc et al.   NATURE

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

(2008) Witold Filipowicz et al.   NATURE REVIEWS GENETICS

Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver

(2008) Z. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA