Article
Biochemistry & Molecular Biology
Nonhlakanipho F. Sangweni, Kwazi Gabuza, Ruzayda van Aarde, Lawrence Mabasa, Derick van Vuuren, Barbara Huisamen, Reenen Barry, Rabia Johnson
Summary: In this study, the protective effects of 7-hydroxyflavanone (7H), a flavonoid with antioxidative properties, against doxorubicin-induced cardiotoxicity (DIC) were investigated in an in vitro model. The results showed that 7H co-treatment alleviated oxidative stress, improved mitochondrial function, and attenuated apoptosis and necrosis. These findings suggest that 7H could be a potential cardioprotective agent against DIC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yazdan Naderi, Sara Khosraviani, Saba Nasiri, Fahimeh Hajiaghaei, Ehsan Aali, Tannaz Jamialahmadi, Maciej Banach, Amirhossein Sahebkar
Summary: The study evaluated the cardioprotective effects of minocycline against doxorubicin-induced cardiotoxicity in adult male rats. Results showed that minocycline significantly decreased the activity of lactate dehydrogenase and creatine kinase MB, while increasing the activity of catalase and superoxide dismutase in cardiac tissue. Minocycline also reduced the levels of malondialdehyde, TNF-alpha, and IL-18 in cardiac tissue, and alleviated the tissue damage caused by doxorubicin.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Yihai Liu, Xuan Wei, Mingyue Wu, Jiamin Xu, Biao Xu, Lina Kang
Summary: The study found that BHB could protect from DOX-induced cardiotoxicity by inhibiting cell apoptosis and oxidative stress, and maintaining mitochondrial membrane integrity.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rony Abdi Syahputra, Urip Harahap, Aminah Dalimunthe, M. Pandapotan Nasution, Denny Satria
Summary: Doxorubicin is a widely used anticancer drug, but its therapeutic value is hindered by dose-dependent cardiotoxicity. This review summarizes the cardioprotective effects of flavonoids against doxorubicin-induced cardiac toxicity in both in vitro and in vivo models.
Article
Chemistry, Medicinal
Farhad Eisvand, Mohsen Imenshahidi, Mahboobeh Ghasemzadeh Rahbardar, Seyed Abbas Tabatabaei Yazdi, Maryam Rameshrad, Bibi Marjan Razavi, Hossein Hosseinzadeh
Summary: Doxorubicin can lead to cardiotoxicity, while alpha-mangostin exerts protective effects against doxorubicin-induced cardiotoxicity through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms, improving heart function and ameliorating heart tissue damage.
PHYTOTHERAPY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ronja Bjornstad, Ingeborg Nerbo Reiten, Kaja Skalnes Knudsen, Jan Schjott, Lars Herfindal
Summary: Co-encapsulation of simvastatin and doxorubicin in liposomes can effectively reduce the risk of doxorubicin-induced cardiotoxicity while retaining or even potentiating the anticancer effect of doxorubicin.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Medicine, Research & Experimental
Fatemah A. Alherz, Thanaa A. El-Masry, Walaa A. Negm, Aya H. El-Kadem
Summary: Amentoflavone (AMF) has cardioprotective effects against doxorubicin (DOX) cardiotoxicity through its antioxidant, anti-inflammatory, anti-apoptotic effects and restoration of mitochondrial function.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Azar Hosseini, Mohammad-Kazem Safari, Arezoo Rajabian, Samaneh Boroumand-Noughabi, Ali H. Eid, Yusra Al Dhaheri, Eric Gumpricht, Amirhossein Sahebkar
Summary: The study demonstrated that Rheum turkestanicum extract alleviated doxorubicin-induced cardiac toxicity by modulating oxidative stress-related pathways. Liquid chromatography-mass spectrometry analysis of R. turkestanicum indicated several components with potent pharmacological properties.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hossein Moutabian, Ruhollah Ghahramani-Asl, Tohid Mortezazadeh, Reza Laripour, Asghar Narmani, Hamed Zamani, Gholamreza Ataei, Hamed Bagheri, Bagher Farhood, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: Nano-curcumin can alleviate doxorubicin-induced cardiotoxicity and improve treatment efficacy.
Article
Pharmacology & Pharmacy
Apiwan Arinno, Chayodom Maneechote, Thawatchai Khuanjing, Benjamin Ongnok, Nanthip Prathumsap, Titikorn Chunchai, Busarin Arunsak, Sasiwan Kerdphoo, Krekwit Shinlapawittayatorn, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Studies have shown that melatonin and metformin can reduce oxidative stress, inflammation, autophagy, apoptosis, and improve mitochondrial function to protect against Doxorubicin-induced cardiotoxicity.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiaoyu Fu, Mathew Eggert, Sieun Yoo, Nikhil Patel, Juming Zhong, Ian Steinke, Manoj Govindarajulu, Emine Akyuz Turumtay, Shravanthi Mouli, Peter Panizzi, Ronald Beyers, Thomas Denney, Robert Arnold, Rajesh H. Amin
Summary: Doxorubicin (DOX) is a cancer chemotherapeutic agent with cardiotoxicity issues, while PAESe has shown effectiveness in mitigating DOX-induced cardiac hypertrophy through its antioxidative properties. The study found that DOX affects mitochondrial function and iron-sulfur cluster biogenesis, whereas PAESe protects against these effects and enhances cellular respiration.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Tavga Ahmed Aziz
Summary: The study evaluated the cardioprotective effects of quercetin and sitagliptin combination in doxorubicin-induced cardiotoxicity. Results demonstrated that the combination treatment was more effective in restoring several markers compared to individual treatments. The combination showed potential for clinical testing due to its additive effects in antioxidant, anti-inflammatory, lipid lowering, and anti-atherogenic activities.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ivana Sirangelo, Maria Liccardo, Clara Iannuzzi
Summary: The major phenolic compound HT in olive oil shows potential in counteracting cardiotoxicity induced by Dox while not interfering with its anti-tumor properties. This study identifies HT as a promising molecule for the development of additional therapeutic approaches to prevent anthracycline-related cardiotoxicity and improve antineoplastic treatments.
Article
Nutrition & Dietetics
Salwa R. Abo El-Ela, Randa A. Zaghloul, Laila A. Eissa
Summary: Baicalin, a flavonoid extracted from Scutellariae baicalensis Georgi, exhibits potential in attenuating doxorubicin-induced cardiotoxicity. It has anti-inflammatory and antioxidant effects, and can inhibit the TLR4/NF-kB pathway while activating the Wnt/β-catenin pathway.
Article
Biochemistry & Molecular Biology
Paulina Koczurkiewicz-Adamczyk, Katarzyna Klas, Agnieszka Gunia-Krzyzak, Kamil Piska, Kalina Andrysiak, Jacek Stepniewski, Slawomir Lasota, Katarzyna Wojcik-Pszczola, Jozef Dulak, Zbigniew Madeja, Elzbieta Pekala
Summary: Cinnamic acid (CA) derivatives show a multitarget protective effect against DOX-induced cardiotoxicity by ameliorating oxidative stress and viability reduction in cardiomyocytes. Further research is encouraged to elucidate the exact molecular mechanism of these compounds' activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
G. B. Rosa, L. C. Cavalet, A. B. S. de Melo, M. D. F. Junior, P. R. Lopes, R. A. Cardoso, L. A. Ferreira, F. D. Tome, P. R. A. Nagib, M. R. N. Celes, G. R. Pedrino, C. H. Castro, P. C. F. Mathias, R. M. Gomes
BRITISH JOURNAL OF NUTRITION
(2020)
Article
Multidisciplinary Sciences
Jose Rodrigues do Carmo Neto, Marcos Vinicius da Silva, Yarlla Loyane Lira Braga, Arthur Wilson Florencio da Costa, Simone Goncalves Fonseca, Patricia Resende Alo Nagib, Mara Rubia Nunes Celes, Milton Adriano Pelli Oliveira, Juliana Reis Machado
Summary: In a study using C57Bl/6 mice infected with T. cruzi Y strain, it was found that BMP2 and IFN gamma production in the intestine increased during the acute phase and correlated with inflammatory infiltrate. A decrease in the number of neurons in the myenteric plexus was observed during this phase. Collagen deposition gradually increased throughout the infection, especially in the chronic phase.
Review
Pathology
Simone Gusmao Ramos, Bruna Amanda da Cruz Rattis, Giulia Ottaviani, Mara Rubia Nunes Celes, Eliane Pedra Dias
Summary: COVID-19, caused by SARS-CoV-2, produces extensive damage to the body and affects important organ systems, leading to changes in microcirculation and injury mechanisms in different organs. The research provides a new assessment of COVID-19, exploring it as a transient molecular disease, and offers new insights for a rational treatment strategy.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Cell Biology
Bruna A. C. Rattis, Ana C. Freitas, Jordana F. Oliveira, Joao L. A. Calandrini-Lima, Maria J. Figueiredo, Danilo F. Soave, Simone G. Ramos, Mara R. N. Celes
Summary: Sepsis-induced myocardial dysfunction leads to altered expression of CAV3 in the heart, with potential implications for L-type calcium channel regulation. This study suggests a crucial role for CAV3 in the development of cardiac dysfunction in sepsis and highlights the potential link between L-type calcium channels and CAV3 expression.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Pharmacology & Pharmacy
Brune A. C. Rattis, Simone G. Ramos, Mara R. N. Celes
Summary: COVID-19 is a highly infectious disease with high mortality rates, posing challenges in patient management. Curcumin, a natural compound with multiple mechanisms of action, is considered beneficial in the treatment of COVID-19.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Jose Rodrigues do Carmo Neto, Yarlla Loyane Lira Braga, Arthur Wilson Florencio da Costa, Fernanda Helia Lucio, Thais Cardoso do Nascimento, Marlene Antonia dos Reis, Mara Rubia Nunes Celes, Flavia Aparecida de Oliveira, Juliana Reis Machado, Marcos Vinicius da Silva
Summary: The progression of Chagasic megacolon is influenced by the association between inflammatory processes and intestinal neuronal destruction, with components such as neuronal subpopulations, enteric glial cells, mast cells, and homeostasis-related proteins playing crucial roles in both the long-term progression and control of the disease. The review aims to uncover the characteristics of the intestinal microenvironment in Chagasic megacolon by analyzing different biomarkers, which may lead to new therapeutic options and enhance understanding of the association between T. cruzi infection and changes in the immune, endocrine, and neurological systems.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Cell Biology
Jose Rodrigues Neto, Arthur Wilson Florencio da Costa, Yarlla Loyane Lira Braga, Fernanda Helia Lucio, Ana Luisa Monteiro dos Santos Martins, Marlene Antonia dos Reis, Flavia Aparecida de Oliveira, Mara Rubia Nunes Celes, Marcos Vinicius da Silva, Milton Adriano Pelli Oliveira, Juliana Reis Machado
Summary: This study aimed to evaluate the histopathological changes caused by infection with the Colombian strain of Trypanosoma cruzi in acute and chronic phases. Results showed that the infection led to weight loss, intestinal inflammatory infiltrates, increased levels of interferon gamma and tumor necrosis factor-alpha, as well as elevated interleukin-10 in the early chronic phase.
MEDIATORS OF INFLAMMATION
(2022)
Article
Immunology
Yarlla L. L. Braga, Jose R. C. Neto, Arthur W. F. Costa, Muriel V. T. Silva, Marcos V. Silva, Mara R. N. Celes, Milton A. P. Oliveira, Leo A. B. Joosten, Fatima Ribeiro-Dias, Rodrigo S. Gomes, Juliana R. Machado
Summary: IL-32 gamma plays a crucial role in controlling acute phase Chagas disease by influencing immune response characteristics and myocarditis.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Immunology
Ana Paula Junqueira-Kipnis, Carine de Castro Souza, Ana Carolina de Oliveira Carvalho, Fabio Muniz de Oliveira, Vinnycius Pereira Almeida, Alisson Rodrigues de Paula, Mara Rubia Celes, Andre Kipnis
Summary: A new tuberculosis vaccine PEPf was developed, which can reduce lung bacterial load and improve protection. Combining PEPf with the Advax4 adjuvant and using a prime-boost strategy as a subunit vaccine significantly enhances protection.
Article
Pharmacology & Pharmacy
Andre Lopes Saraiva, Allisson Benatti Justino, Rodrigo Rodrigues Franco, Heitor Cappato Guerra Silva, Felipe dos Santos Arruda, Sandra Gabriela Klein, Mara Rubia Nunes Celes, Luiz Ricardo Goulart, Foued Salmen Espindola
Summary: In this study, the antioxidant and anti-inflammatory activities of polyphenols-rich fractions from Annona muricata L. leaves were investigated. The fractions reduced the generation of reactive oxygen species and secretion of inflammatory markers in immune cells. Furthermore, these fractions attenuated oxidative damage and inflammation in experimental acute lung injury. These findings suggest that these fractions might be explored for the development of new therapies for inflammatory conditions.
Article
Pharmacology & Pharmacy
Bruna A. C. Rattis, Henrique L. Piva, Andressa Duarte, Frederico G. F. L. R. Gomes, Janaina R. Lellis, Danilo F. Soave, Simone G. Ramos, Antonio C. Tedesco, Mara R. N. Celes
Summary: Curcumin showed cardioprotective effects in septic mice by reducing the expression of mTOR pathway-related genes, potentially achieved through modulation of the mTOR pathway.
Article
Biochemistry & Molecular Biology
Pablo Igor Ribeiro Franco, Jose Rodrigues do Carmo Neto, Marina Pacheco Miguel, Juliana Reis Machado, Mara Rubia Nunes Celes
Summary: This review summarizes the main molecular mechanisms of T. cruzi-related carcinogenesis and the mechanisms associated with tumor protection mediated by different parasite components.
Article
Pharmacology & Pharmacy
Maria Clara C. Cordeiro, Fernanda D. Tome, Felipe S. Arruda, Simone Goncalves da Fonseca, Patricia R. A. Nagib, Mara R. N. Celes
Summary: This study found that curcumin can interfere with macrophage function and polarization in malaria. It enhances the phagocytic activity of macrophages, particularly in non-inflammatory conditions, and promotes a balance in macrophage polarization by interfering with arginine availability.
Article
Cardiac & Cardiovascular Systems
Lidiane B. Muniz, Aline M. Alves-Santos, Fabricio Camargo, Danieli Brolo Martins, Mara Rubia N. Celes, Maria Margareth Naves
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2019)
