Toll-like receptor 4 mutation suppresses hyperhomocysteinemia-induced hypertension

Inhibition of Hyperhomocysteinemia-Induced Inflammasome Activation and Glomerular Sclerosis by NLRP3 Gene Deletion

(2017) Min Xia et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hyperhomocysteinemia-induced upper extremity deep vein thrombosis and pulmonary embolism in a patient with methyltetrahydrofolate reductase mutation

(2016) Lin Gao et al.   BLOOD COAGULATION & FIBRINOLYSIS

The toll of the gridiron: damage-associated molecular patterns and hypertension in American football

(2016) Cameron G. McCarthy et al.   FASEB JOURNAL

Cystathionine β-synthase regulates endothelial function via protein S-sulfhydration

(2016) Sounik Saha et al.   FASEB JOURNAL

Reversal of right ventricular remodeling by dichloroacetate is related to inhibition of mitochondria-dependent apoptosis

(2016) Xiao-Qing Sun et al.   HYPERTENSION RESEARCH

p120 catenin attenuates the angiotensin II-induced apoptosis of human umbilical vein endothelial cells by suppressing the mitochondrial pathway

(2016) YAN ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

High Methionine Diet Poses Cardiac Threat: A Molecular Insight

(2016) Pankaj Chaturvedi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

LEADER-4

(2016) John R. Petrie et al.   JOURNAL OF HYPERTENSION

Folic Acid and Vitamins D and B12 Correlate With Homocysteine in Chinese Patients With Type-2 Diabetes Mellitus, Hypertension, or Cardiovascular Disease

(2016) Xudong Mao et al.   MEDICINE

Coenzyme Q10 Attenuates High Glucose-Induced Endothelial Progenitor Cell Dysfunction through AMP-Activated Protein Kinase Pathways

(2016) Hsiao-Ya Tsai et al.   Journal of Diabetes Research

Placental Regulation of Inflammation and Hypoxia after TNF-α Infusion in Mice

(2015) Gabriele Bobek et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Phosphocreatine protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway

(2015) Anil Ahsan et al.   APOPTOSIS

Macrophages in vascular inflammation – From atherosclerosis to vasculitis

(2015) Tsuyoshi Shirai et al.   AUTOIMMUNITY

Neuroprotective Effects of Dexmedetomidine Against Hypoxia-Induced Nervous System Injury are Related to Inhibition of NF-κB/COX-2 Pathways

(2015) Wanying Pan et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Homocysteine andMTHFRMutations

(2015) Stephan Moll et al.   CIRCULATION

Emerging Role of Nitric Oxide and Heat Shock Proteins in Insulin Resistance

(2015) Marisa Nile Molina et al.   CURRENT HYPERTENSION REPORTS

Hyperhomocysteinemia suppresses bone marrow CD34+/VEGF receptor 2+ cells and inhibits progenitor cell mobilization and homing to injured vasculature—a role of β1-integrin in progenitor cell migration and adhesion

(2015) Jun Nelson et al.   FASEB JOURNAL

Transglutaminase 2 is involved in homocysteine-induced activation of human THP-1 monocytes

(2015) M. Currò et al.   FREE RADICAL RESEARCH

Homocysteine Triggers Inflammatory Responses in Macrophages through Inhibiting CSE-H2S Signaling via DNA Hypermethylation of CSE Promoter

(2015) Jiao-Jiao Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lectin-like oxidized low-density lipoprotein receptor-1 regulates autophagy and Toll-like receptor 4 in the brain of hypertensive mice

(2015) Zufeng Ding et al.   JOURNAL OF HYPERTENSION

Toll-like receptor 4 inhibition within the paraventricular nucleus attenuates blood pressure and inflammatory response in a genetic model of hypertension

(2015) Rahul B Dange et al.   Journal of Neuroinflammation

Protective effects of genistein in homocysteine-induced endothelial cell inflammatory injury

(2015) Shengbo Han et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease

(2015) Tommy Pacana et al.   PLoS One

Pathological concentrations of homocysteine increases IL-1β production in macrophages in a P2X7, NF-ĸB, and erk-dependent manner

(2015) Rafael Fernandes Zanin et al.   Purinergic Signalling

Genetic contribution in sporadic thoracic aortic aneurysm? Emerging evidence of genetic variants related to TLR-4-mediated signaling pathway as risk determinants

(2015) Carmela Rita Balistreri   VASCULAR PHARMACOLOGY

The Bcl-2 family: structures, interactions and targets for drug discovery

(2014) Marc Kvansakul et al.   APOPTOSIS

Central blockade of TLR4 improves cardiac function and attenuates myocardial inflammation in angiotensin II-induced hypertension

(2014) Rahul B. Dange et al.   CARDIOVASCULAR RESEARCH

Hydrogen sulfide as a potent cardiovascular protective agent

(2014) Xiao-Hua Yu et al.   CLINICA CHIMICA ACTA

Epigenetic regulation of aortic remodeling in hyperhomocysteinemia

(2014) Nithya Narayanan et al.   FASEB JOURNAL

Can the TLR-4-Mediated Signaling Pathway Be “A Key Inflammatory Promoter for Sporadic TAA”?

(2014) Giovanni Ruvolo et al.   MEDIATORS OF INFLAMMATION

Mild Hyperhomocysteinemia Increases Brain Acetylcholinesterase and Proinflammatory Cytokine Levels in Different Tissues

(2014) Emilene B. S. Scherer et al.   MOLECULAR NEUROBIOLOGY

Protection of Ischemic Postconditioning against Neuronal Apoptosis Induced by Transient Focal Ischemia Is Associated with Attenuation of NF-κB/p65 Activation

(2014) Jianmin Liang et al.   PLoS One

Toll-Like Receptor 4 Upregulation by Angiotensin II Contributes to Hypertension and Vascular Dysfunction through Reactive Oxygen Species Production

(2014) Priscila R. De Batista et al.   PLoS One

Toll-like receptors and damage-associated molecular patterns: novel links between inflammation and hypertension

(2013) Cameron G. McCarthy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Toll-Like Receptor 4 Mutation Protects Obese Mice Against Endothelial Dysfunction by Decreasing NADPH Oxidase Isoforms 1 and 4

(2013) Chao-Fan Liang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Folic Acid Mitigates Angiotensin-II-Induced Blood Pressure and Renal Remodeling

(2013) Sathnur B. Pushpakumar et al.   PLoS One

Severe Hyperhomocysteinemia Promotes Bone Marrow–Derived and Resident Inflammatory Monocyte Differentiation and Atherosclerosis in LDLr/CBS-Deficient Mice

(2012) Daqing Zhang et al.   CIRCULATION RESEARCH

Toll-like receptor 4 contributes to blood pressure regulation and vascular contraction in spontaneously hypertensive rats

(2012) Gisele F. Bomfim et al.   CLINICAL SCIENCE

Protection by silibinin against experimental ischemic stroke: Up-regulated pAkt, pmTOR, HIF-1α and Bcl-2, down-regulated Bax, NF-κB expression

(2012) Chaohui Wang et al.   NEUROSCIENCE LETTERS

Acid Sphingomyelinase Gene Knockout Ameliorates Hyperhomocysteinemic Glomerular Injury in Mice Lacking Cystathionine-β-Synthase

(2012) Krishna M. Boini et al.   PLoS One

Homocysteine-Induced Apoptosis in Endothelial Cells Coincides With Nuclear NOX2 and Peri-nuclear NOX4 Activity

(2011) Jessica A. Sipkens et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Heart Disease and Stroke Statistics—2012 Update

(2011) et al.   CIRCULATION

Vitamin B12 protects against superoxide-induced cell injury in human aortic endothelial cells

(2011) Edward S. Moreira et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypertension augments cardiac Toll-like receptor 4 expression and activity

(2011) Ruth Eißler et al.   HYPERTENSION RESEARCH

Mechanisms of Cardiovascular Remodeling in Hyperhomocysteinemia

(2010) Mesia M. Steed et al.   ANTIOXIDANTS & REDOX SIGNALING

Endogenous Inflammatory Molecules Engage Toll-Like Receptors in Cardiovascular Disease

(2010) Mihaela G. Ionita et al.   Journal of Innate Immunity

Toll-like receptors 4 induces expression of matrix metalloproteinase-9 in human aortic smooth muscle cells

(2010) Hongli Li et al.   MOLECULAR BIOLOGY REPORTS

Hydrogen sulfide: Regulatory role on blood pressure in hyperhomocysteinemia

(2010) Sagiraju Sowmya et al.   VASCULAR PHARMACOLOGY

Vessel-Specific Toll-Like Receptor Profiles in Human Medium and Large Arteries

(2008) Olga Pryshchep et al.   CIRCULATION

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY