Elevated expression of GNAS promotes breast cancer cell proliferation and migration via the PI3K/AKT/Snail1/E-cadherin axis

GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer

(2018) Raksha R. Bhat et al.   BREAST CANCER RESEARCH AND TREATMENT

GNAS mutations in primary mucinous and non-mucinous lung adenocarcinomas

(2017) Lauren L Ritterhouse et al.   MODERN PATHOLOGY

Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer

(2017) Hui Liu et al.   Cancer Discovery

GPCR Signaling Mediates Tumor Metastasis via PI3K 

(2016) B. D. Khalil et al.   CANCER RESEARCH

Tubular, lactating, and ductal adenomas are devoid of MED12 Exon2 mutations, and ductal adenomas show recurrent mutations in GNAS and the PI3K-AKT pathway

(2016) Anna-Lena Volckmar et al.   GENES CHROMOSOMES & CANCER

G protein-coupled receptors (GPCRs) That Signal via Protein Kinase A (PKA) Cross-talk at Insulin Receptor Substrate 1 (IRS1) to Activate the phosphatidylinositol 3-kinase (PI3K)/AKT Pathway

(2016) Nathan C. Law et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of G s α impairs liver regeneration through a defect in the crosstalk between cAMP and growth factor signaling

(2016) Changli Lu et al.   JOURNAL OF HEPATOLOGY

Regulation, Signaling, and Physiological Functions of G-Proteins

(2016) Viktoriya Syrovatkina et al.   JOURNAL OF MOLECULAR BIOLOGY

CITED2 Modulates Breast Cancer Metastatic Ability through Effects on IKK 

(2016) S. Jayaraman et al.   MOLECULAR CANCER RESEARCH

Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases

(2016) Jing Ni et al.   NATURE MEDICINE

The untapped potential of tyrosine-based G protein signaling

(2016) Pradipta Ghosh   PHARMACOLOGICAL RESEARCH

The relevance of EMT in breast cancer metastasis: Correlation or causality?

(2015) Ruben Bill et al.   FEBS LETTERS

Clinical Significance of GNAS Mutation in Intraductal Papillary Mucinous Neoplasm of the Pancreas With Concomitant Pancreatic Ductal Adenocarcinoma

(2015) Noboru Ideno et al.   PANCREAS

PI3K/AKT signaling pathway and cancer: an updated review

(2014) Miriam Martini et al.   ANNALS OF MEDICINE

PKA signaling drives mammary tumorigenesis through Src

(2014) A G Beristain et al.   ONCOGENE

Harnessing the genome for characterization of G-protein coupled receptors in cancer pathogenesis

(2013) Michael E. Feigin   FEBS Journal

An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer

(2013) I Garcia-Murillas et al.   ONCOGENE

GPCR activation of Ras and PI3Kγ in neutrophils depends on PLCβ2/β3 and the RasGEF RasGRP4

(2012) Sabine Suire et al.   EMBO JOURNAL

GNAS imprinting and pituitary tumors

(2010) G. Mantovani et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

G protein-coupled receptors: novel targets for drug discovery in cancer

(2010) Rosamaria Lappano et al.   NATURE REVIEWS DRUG DISCOVERY

Breast Cancer Metastasis: Challenges and Opportunities

(2009) J. Lu et al.   CANCER RESEARCH