An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

(2012) Anirudh Prahallad et al.   NATURE

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane

(2012) S. V. Consonni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ZNF703is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium

(2011) Daniel G. Holland et al.   EMBO Molecular Medicine

ZNF703gene amplification at 8p12 specifies luminal B breast cancer

(2011) Fabrice Sircoulomb et al.   EMBO Molecular Medicine

Extra-long Gαs Variant XLαs Protein Escapes Activation-induced Subcellular Redistribution and Is Able to Provide Sustained Signaling

(2011) Zun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

(2011) H. W. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development

(2011) J. Wu et al.   Science Translational Medicine

Functional Viability Profiles of Breast Cancer

(2011) R. Brough et al.   Cancer Discovery

Potent constitutive cyclic AMP-generating activity of XLαs implicates this imprinted GNAS product in the pathogenesis of McCune–Albright Syndrome and fibrous dysplasia of bone

(2010) Virginie Mariot et al.   BONE

FGFR1 Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer

(2010) N. Turner et al.   CANCER RESEARCH

Alteration of Topoisomerase II–Alpha Gene in Human Breast Cancer: Association With Responsiveness to Anthracycline-Based Chemotherapy

(2010) Michael F. Press et al.   JOURNAL OF CLINICAL ONCOLOGY

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade

(2010) F. Donelson Smith et al.   NATURE CELL BIOLOGY

Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer

(2010) J. Weiss et al.   Science Translational Medicine

A high-resolution integrated analysis of genetic and expression profiles of breast cancer cell lines

(2009) Alan Mackay et al.   BREAST CANCER RESEARCH AND TREATMENT

An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers

(2009) Rachael Natrajan et al.   BREAST CANCER RESEARCH AND TREATMENT

Tiling Path Genomic Profiling of Grade 3 Invasive Ductal Breast Cancers

(2009) R. Natrajan et al.   CLINICAL CANCER RESEARCH

Extralarge XLαs (XXLαs), a Variant of Stimulatory G Protein α-Subunit (Gsα), Is a Distinct, Membrane-AnchoredGNASProduct that Can Mimic Gsα

(2009) Cumhur Aydin et al.   ENDOCRINOLOGY

Complex landscapes of somatic rearrangement in human breast cancer genomes

(2009) Philip J. Stephens et al.   NATURE

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

(2008) Nicholas C Turner et al.   EMBO JOURNAL

Wheels within Wheels: Clues to the Evolution of the Gnas and Gnal Loci

(2008) S. Wadhawan et al.   MOLECULAR BIOLOGY AND EVOLUTION