G protein-coupled receptors (GPCRs) That Signal via Protein Kinase A (PKA) Cross-talk at Insulin Receptor Substrate 1 (IRS1) to Activate the phosphatidylinositol 3-kinase (PI3K)/AKT Pathway

Follicle-Stimulating Hormone (FSH)-dependent Regulation of Extracellular Regulated Kinase (ERK) Phosphorylation by the Mitogen-activated Protein (MAP) Kinase Phosphatase MKP3

(2016) Elyse M. Donaubauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dephosphorylation of MAP2D enhances its binding to vimentin in preovulatory ovarian granulosa cells

(2016) Maxfield P. Flynn et al.   JOURNAL OF CELL SCIENCE

Forkhead box O member FOXO1 regulates the majority of follicle-stimulating hormone responsive genes in ovarian granulosa cells

(2016) Maria K. Herndon et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Protein Kinase A: A Master Kinase of Granulosa Cell Differentiation

(2016) Pawan Puri et al.   Scientific Reports

Intraovarian Control of Early Folliculogenesis

(2015) Aaron J. W. Hsueh et al.   ENDOCRINE REVIEWS

Insulin Receptor Substrate 1, the Hub Linking Follicle-stimulating Hormone to Phosphatidylinositol 3-Kinase Activation

(2015) Nathan C. Law et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development

(2015) Zhilin Liu et al.   MOLECULAR ENDOCRINOLOGY

A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation

(2015) Guang Yang et al.   Cell Reports

Insulin and Metabolic Stress Stimulate Multisite Serine/Threonine Phosphorylation of Insulin Receptor Substrate 1 and Inhibit Tyrosine Phosphorylation

(2014) Nancy J. Hançer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IGF1R Signaling Is Necessary for FSH-Induced Activation of AKT and Differentiation of Human Cumulus Granulosa Cells

(2014) Sarah C. Baumgarten et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Quantitative phosphoproteomics reveals novel phosphorylation events in insulin signaling regulated by protein phosphatase 1 regulatory subunit 12A

(2014) Xiangmin Zhang et al.   Journal of Proteomics

Role of serine-threonine phosphoprotein phosphatases in smooth muscle contractility

(2013) Trent Butler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

IRS1Ser307 phosphorylation does not mediate mTORC1-induced insulin resistance

(2013) Hilde Herrema et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LhcgrExpression in Granulosa Cells: Roles for PKA-Phosphorylated β-Catenin, TCF3, and FOXO1

(2013) Nathan C. Law et al.   MOLECULAR ENDOCRINOLOGY

Phosphoinositide 3-Kinase p110δ Mediates Estrogen- and FSH-Stimulated Ovarian Follicle Growth

(2013) Qian Li et al.   MOLECULAR ENDOCRINOLOGY

What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-Kinase Pathway

(2013) S. J. Klempner et al.   Cancer Discovery

Targeting the insulin-like growth factor-1 receptor in human cancer

(2013) Alexandre Arcaro   Frontiers in Pharmacology

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Follicle-stimulating Hormone Regulates Pro-apoptotic Protein Bcl-2-interacting Mediator of Cell Death-Extra Long (Bim EL )-induced Porcine Granulosa Cell Apoptosis

(2012) Xian-Long Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKA and GAB2 play central roles in the FSH signaling pathway to PI3K and AKT in ovarian granulosa cells

(2012) M. E. Hunzicker-Dunn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Label-Free Proteomic Identification of Endogenous, Insulin-Stimulated Interaction Partners of Insulin Receptor Substrate-1

(2011) Thangiah Geetha et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Phos-tag SDS-PAGE systems for phosphorylation profiling of proteins with a wide range of molecular masses under neutral pH conditions

(2011) Eiji Kinoshita et al.   PROTEOMICS

Irs1 Serine 307 Promotes Insulin Sensitivity in Mice

(2010) Kyle D. Copps et al.   Cell Metabolism

Crosstalk between Insulin/Insulin-like Growth Factor-1 Receptors and G Protein-Coupled Receptor Signaling Systems: A Novel Target for the Antidiabetic Drug Metformin in Pancreatic Cancer

(2010) E. Rozengurt et al.   CLINICAL CANCER RESEARCH

Prostaglandin E2Activates and Utilizes mTORC2 as a Central Signaling Locus for the Regulation of Mast Cell Chemotaxis and Mediator Release

(2010) Hye Sun Kuehn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The extended PP1 toolkit: designed to create specificity

(2010) Mathieu Bollen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Differential regulation of vascular smooth muscle and endothelial cell proliferation in vitro and in vivo by cAMP/PKA-activated p85αPI3K

(2009) Daniele Torella et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Obestatin stimulates Akt signalling in gastric cancer cells through β-arrestin-mediated epidermal growth factor receptor transactivation

(2009) Carlos J P Álvarez et al.   ENDOCRINE-RELATED CANCER

Mouse models of altered protein kinase A signaling

(2009) Lawrence S Kirschner et al.   ENDOCRINE-RELATED CANCER

FSH and FOXO1 Regulate Genes in the Sterol/Steroid and Lipid Biosynthetic Pathways in Granulosa Cells

(2009) Zhilin Liu et al.   MOLECULAR ENDOCRINOLOGY

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IGF1 induces up-regulation of steroidogenic and apoptotic regulatory genes via activation of phosphatidylinositol-dependent kinase/AKT in bovine granulosa cells

(2009) Arul Murugan Mani et al.   REPRODUCTION

Interplay and Effects of Temporal Changes in the Phosphorylation State of Serine-302, -307, and -318 of Insulin Receptor Substrate-1 on Insulin Action in Skeletal Muscle Cells

(2008) Cora Weigert et al.   MOLECULAR ENDOCRINOLOGY

PI3K pathway alterations in cancer: variations on a theme

(2008) T L Yuan et al.   ONCOGENE

The p110  isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110 

(2008) J. Guillermet-Guibert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA