Spotlight on 17-AAG as an Hsp90 inhibitor for molecular targeted cancer treatment
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Spotlight on 17-AAG as an Hsp90 inhibitor for molecular targeted cancer treatment
Authors
Keywords
-
Journal
Chemical Biology & Drug Design
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2019-01-30
DOI
10.1111/cbdd.13486
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor: Overview and current state of the art
- (2018) Hassan Mellatyar et al. BIOMEDICINE & PHARMACOTHERAPY
- Chrysin-nanoencapsulated PLGA-PEG for macrophage repolarization: Possible application in tissue regeneration
- (2018) Akram Firouzi-Amandi et al. BIOMEDICINE & PHARMACOTHERAPY
- 17-DMAG-loaded nanofibrous scaffold for effective growth inhibition of lung cancer cells through targeting HSP90 gene expression
- (2018) Hassan Mellatyar et al. BIOMEDICINE & PHARMACOTHERAPY
- A Biomimetic Emu Oil-Blended Electrospun Nanofibrous Mat for Maintaining Stemness of Adipose Tissue-Derived Stem Cells
- (2018) Sepideh Jalilzadeh-Tabrizi et al. BIOPRESERVATION AND BIOBANKING
- A Biomimetic Emu Oil-Blended Electrospun Nanofibrous Mat for Maintaining Stemness of Adipose Tissue-Derived Stem Cells
- (2018) Sepideh Jalilzadeh-Tabrizi et al. Biopreservation and Biobanking
- Encapsulation of the HSP-90 Chaperone Inhibitor 17-AAG in Stable Liposome Allow Increasing the Therapeutic Index as Assessed, in vitro, on Leishmania (L) amazonensis Amastigotes-Hosted in Mouse CBA Macrophages
- (2018) Antonio Luis de Oliveira Almeida Petersen et al. Frontiers in Cellular and Infection Microbiology
- 17-Allylamino-17-demethoxygeldanamycin loaded PCL/PEG nanofibrous scaffold for effective growth inhibition of T47D breast cancer cells
- (2018) Sona Talaei et al. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
- Epothilone B-based 3-in-1 polymeric micelle for anticancer drug therapy
- (2017) Dae Hwan Shin et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Topically Applied Hsp90 Blocker 17AAG Inhibits Autoantibody-Mediated Blister-Inducing Cutaneous Inflammation
- (2017) Stefan Tukaj et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Synthesis of polymeric nano/microgels: a review
- (2017) Yusof Bin Hamzah et al. JOURNAL OF POLYMER RESEARCH
- Co-Delivery of Curcumin and Chrysin by Polymeric Nanoparticles Inhibit Synergistically Growth and hTERT Gene Expression in Human Colorectal Cancer Cells
- (2017) Javid Lotfi-Attari et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Multi-drug loaded micelles delivering chemotherapy and targeted therapies directed against HSP90 and the PI3K/AKT/mTOR pathway in prostate cancer
- (2017) Bao Le et al. PLoS One
- Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer
- (2017) Helga Weber et al. Oncotarget
- Macrophage repolarization using emu oil-based electrospun nanofibers: possible application in regenerative medicine
- (2017) Reza Zamani et al. Artificial Cells Nanomedicine and Biotechnology
- Watercress-based electrospun nanofibrous scaffolds enhance proliferation and stemness preservation of human adipose-derived stem cells
- (2017) Mehdi Dadashpour et al. Artificial Cells Nanomedicine and Biotechnology
- An in vitro examination of the antioxidant, cytoprotective and anti-inflammatory properties of chrysin-loaded nanofibrous mats for potential wound healing applications
- (2017) Yaghoub Deldar et al. Artificial Cells Nanomedicine and Biotechnology
- Nano-encapsulated metformin-curcumin in PLGA/PEG inhibits synergistically growth and hTERT gene expression in human breast cancer cells
- (2017) Raana Farajzadeh et al. Artificial Cells Nanomedicine and Biotechnology
- Silibinin-loaded magnetic nanoparticles inhibit hTERT gene expression and proliferation of lung cancer cells
- (2017) Soumaye Amirsaadat et al. Artificial Cells Nanomedicine and Biotechnology
- Development of quantum-dot-encapsulated liposome-based optical nanobiosensor for detection of telomerase activity without target amplification
- (2016) Ali Zavari-Nematabad et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Upregulation of Mir-34a in AGS Gastric Cancer Cells by a PLGA-PEG-PLGA Chrysin Nano Formulation
- (2016) Farideh Mohammadian et al. Asian Pacific Journal of Cancer Prevention
- Design and development of PCR-free highly sensitive electrochemical assay for detection of telomerase activity using Nano-based (liposomal) signal amplification platform
- (2016) Mohammadreza Alizadeh-Ghodsi et al. BIOSENSORS & BIOELECTRONICS
- Trends on polymer- and lipid-based nanostructures for parenteral drug delivery to tumors
- (2016) Elham Ajorlou et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Jump in the fire — heat shock proteins and their impact on ovarian cancer therapy
- (2016) M.B. Stope et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Dual mode of cancer cell destruction for pancreatic cancer therapy using Hsp90 inhibitor loaded polymeric nano magnetic formulation
- (2016) Ankit K. Rochani et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation
- (2016) Kruti S. Soni et al. JOURNAL OF CONTROLLED RELEASE
- Triolimus: A Multi-Drug Loaded Polymeric Micelle Containing Paclitaxel, 17-AAG, and Rapamycin as a Novel Radiosensitizer
- (2016) Keishiro Tomoda et al. MACROMOLECULAR BIOSCIENCE
- Marked enhancement of lysosomal targeting and efficacy of ErbB2-targeted drug delivery by HSP90 inhibition
- (2016) Srikumar M. Raja et al. Oncotarget
- Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells
- (2016) Arefeh Rouhi et al. Oncotarget
- HSP90 Inhibitor Encapsulated Photo-Theranostic Nanoparticles for Synergistic Combination Cancer Therapy
- (2016) Tzu-yin Lin et al. Theranostics
- Hyaluronic acid-decorated poly(lactic-co-glycolic acid) nanoparticles for combined delivery of docetaxel and tanespimycin
- (2015) Roshan Pradhan et al. CARBOHYDRATE POLYMERS
- Heat shock proteins in hepatocellular carcinoma: Molecular mechanism and therapeutic potential
- (2015) Cun Wang et al. INTERNATIONAL JOURNAL OF CANCER
- Inhibition of heat-shock protein 90 sensitizes liver cancer stem-like cells to magnetic hyperthermia and enhances anti-tumor effect on hepatocellular carcinoma-burdened nude mice
- (2015) Rui Yang et al. International Journal of Nanomedicine
- Phase II trial of gemcitabine and tanespimycin (17AAG) in metastatic pancreatic cancer: a Mayo Clinic Phase II Consortium study
- (2015) Katrina S. Pedersen et al. INVESTIGATIONAL NEW DRUGS
- Polypeptide-based nanogels co-encapsulating a synergistic combination of doxorubicin with 17-AAG show potent anti-tumor activity in ErbB2-driven breast cancer models
- (2015) Swapnil S. Desale et al. JOURNAL OF CONTROLLED RELEASE
- Topically Applied Hsp90 Inhibitor 17AAG Inhibits UVR-Induced Cutaneous Squamous Cell Carcinomas
- (2015) Anupama Singh et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- The HSP90 inhibitor 17-AAG exhibits potent antitumor activity for pheochromocytoma in a xenograft model
- (2015) Yunze Xu et al. TUMOR BIOLOGY
- The combination of Hsp90 inhibitor 17AAG and heavy-ion irradiation provides effective tumor control in human lung cancer cells
- (2015) Hirokazu Hirakawa et al. Cancer Medicine
- Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells
- (2015) Young Eun Choi et al. Oncotarget
- Inhibitory Effects of β-Cyclodextrin-Helenalin Complexes on H-TERT Gene Expression in the T47D Breast Cancer Cell Line - Results of Real Time Quantitative PCR
- (2014) Samaneh Ghasemali et al. Asian Pacific Journal of Cancer Prevention
- Comparison of Inhibitory Effect of 17-DMAG Nanoparticles and Free 17-DMAG in HSP90 Gene Expression in Lung Cancer
- (2014) Hassan Mellatyar et al. Asian Pacific Journal of Cancer Prevention
- Comparison of Inhibitory Effects of 17-AAG Nanoparticles and Free 17-AAG on HSP90 Gene Expression in Breast Cancer
- (2014) Masoud Gandomkar Ghalhar et al. Asian Pacific Journal of Cancer Prevention
- Formulation and in vitro evaluation of 17-allyamino-17-demethoxygeldanamycin (17-AAG) loaded polymeric mixed micelles for glioblastoma multiforme
- (2013) Vipin Saxena et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- Molecular Mechanism of 17-Allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL Receptor Tyrosine Kinase Degradation
- (2013) Gnana Prakasam Krishnamoorthy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of HSP90 with AUY922 Induces Synergy in HER2-Amplified Trastuzumab-Resistant Breast and Gastric Cancer
- (2013) Z. A. Wainberg et al. MOLECULAR CANCER THERAPEUTICS
- The HSP90 inhibitor 17-N-allylamino-17-demethoxy geldanamycin (17-AAG) synergizes with cisplatin and induces apoptosis in cisplatin-resistant esophageal squamous cell carcinoma cell lines via the Akt/XIAP pathway
- (2013) TAKASHI UI et al. ONCOLOGY REPORTS
- Combination of Rapamycin, CI-1040, and 17-AAG Inhibits Metastatic Capacity of Prostate Cancer via Slug Inhibition
- (2013) Guanxiong Ding et al. PLoS One
- The Effects of Heat Shock Protein 90 Inhibitors on Apoptosis and Viral Replication in Primary Effusion Lymphoma Cells
- (2012) Chizuka Higashi et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- HSP90 Inhibitor 17-AAG Selectively Eradicates Lymphoma Stem Cells
- (2012) B. Newman et al. CANCER RESEARCH
- The heat shock protein 90 inhibitor 17-AAG suppresses growth and induces apoptosis in human cholangiocarcinoma cells
- (2012) Jianjun Zhang et al. CLINICAL AND EXPERIMENTAL MEDICINE
- Folate receptor targeted 17-allylamino-17-demethoxygeldanamycin (17-AAG) loaded polymeric nanoparticles for breast cancer
- (2012) Vipin Saxena et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- The Therapeutic Target Hsp90 and Cancer Hallmarks
- (2012) Yoshihiko Miyata et al. CURRENT PHARMACEUTICAL DESIGN
- Paclitaxel-incorporated nanoparticles of hydrophobized polysaccharide and their antitumor activity
- (2012) Sang Joon Lee et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs
- (2012) Ying Lu et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Pharmacokinetics and dose escalation of the heat shock protein inhibitor 17-allyamino-17-demethoxygeldanamycin in combination with bortezomib in relapsed or refractory acute myeloid leukemia
- (2012) Alison R. Walker et al. LEUKEMIA & LYMPHOMA
- Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG
- (2012) J. R. Hasenstein et al. MOLECULAR CANCER THERAPEUTICS
- Nano Self-Assembly of Recombinant Human Gelatin Conjugated with α-Tocopheryl Succinate for Hsp90 Inhibitor, 17-AAG, Delivery
- (2011) Young-Wook Won et al. ACS Nano
- Hsp90 inhibitors and drug resistance in cancer: The potential benefits of combination therapies of Hsp90 inhibitors and other anti-cancer drugs
- (2011) Xiangyi Lu et al. BIOCHEMICAL PHARMACOLOGY
- Aggregation-enhanced fluorescence in PEGylated phospholipid nanomicelles for in vivo imaging
- (2011) Dan Wang et al. BIOMATERIALS
- A phase II study of 17-allylamino-17-demethoxygeldanamycin in metastatic or locally advanced, unresectable breast cancer
- (2011) Elaina M. Gartner et al. BREAST CANCER RESEARCH AND TREATMENT
- Tanespimycin and bortezomib combination treatment in patients with relapsed or relapsed and refractory multiple myeloma: results of a phase 1/2 study
- (2011) Paul G. Richardson et al. BRITISH JOURNAL OF HAEMATOLOGY
- A phase I trial of docetaxel and pulse-dose 17-allylamino-17-demethoxygeldanamycin in adult patients with solid tumors
- (2011) Gopa Iyer et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab
- (2011) S. Modi et al. CLINICAL CANCER RESEARCH
- Phase I and pharmacological study of cytarabine and tanespimycin in relapsed and refractory acute leukemia
- (2011) S. H. Kaufmann et al. HAEMATOLOGICA
- Synthesis and evaluation of poly(styrene-co-maleic acid) micellar nanocarriers for the delivery of tanespimycin
- (2011) Nate Larson et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Multi-drug delivery to tumor cells via micellar nanocarriers
- (2011) Usha Katragadda et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Hsp90 inhibitor 17-AAG inhibits progression of LuCaP35 xenograft prostate tumors to castration resistance
- (2011) Katherine J. O'Malley et al. PROSTATE
- 17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells
- (2010) Panagiotis K Karkoulis et al. BMC CANCER
- A combination of Trastuzumab and 17-AAG induces enhanced ubiquitinylation and lysosomal pathway-dependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cells
- (2010) Srikumar M. Raja et al. CANCER BIOLOGY & THERAPY
- Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of the Combination of Sorafenib and Tanespimycin
- (2010) U. N. Vaishampayan et al. CLINICAL CANCER RESEARCH
- Design and evaluation of micellar nanocarriers for 17-allyamino-17-demethoxygeldanamycin (17-AAG)
- (2010) Thripthy Chandran et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- A Phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma
- (2010) Simon Pacey et al. INVESTIGATIONAL NEW DRUGS
- Phase I study of 17-allylamino-17 demethoxygeldanamycin, gemcitabine and/or cisplatin in patients with refractory solid tumors
- (2010) Joleen Hubbard et al. INVESTIGATIONAL NEW DRUGS
- MEK Inhibition Potentiates the Activity of Hsp90 Inhibitor 17-AAG against Pancreatic Cancer Cells
- (2010) Tao Zhang et al. MOLECULAR PHARMACEUTICS
- EGFR Signaling and Drug Discovery
- (2010) Georg Lurje et al. ONCOLOGY
- Combination of rapamycin and 17-allylamino-17-demethoxygeldanamycin abrogates Akt activation and potentiates mTOR blockade in breast cancer cells
- (2009) Matthew M. Roforth et al. ANTI-CANCER DRUGS
- Targeting Heat Shock Protein 90 Overrides the Resistance of Lung Cancer Cells by Blocking Radiation-Induced Stabilization of Hypoxia-Inducible Factor-1α
- (2009) Woo-Young Kim et al. CANCER RESEARCH
- HSP90 is essential for Jak-STAT signaling in classical Hodgkin lymphoma cells
- (2009) Nils Schoof et al. Cell Communication and Signaling
- 17 AAG for HSP90 Inhibition in Cancer – From Bench to Bedside
- (2009) Saad Usmani et al. CURRENT MOLECULAR MEDICINE
- Folate-targeted therapeutic and imaging agents for cancer
- (2009) Philip Stewart Low et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Tanespimycin: the opportunities and challenges of targeting heat shock protein 90
- (2009) Charles Erlichman EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs
- (2009) Ho-Chul Shin et al. JOURNAL OF CONTROLLED RELEASE
- Heat Shock Protein-90 Inhibitors Increase MHC Class I-Related Chain A and B Ligand Expression on Multiple Myeloma Cells and Their Ability to Trigger NK Cell Degranulation
- (2009) C. Fionda et al. JOURNAL OF IMMUNOLOGY
- Inhibition of 90-kD heat shock protein potentiates the cytotoxicity of chemotherapeutic agents in human glioma cells
- (2009) Shigeo Ohba et al. JOURNAL OF NEUROSURGERY
- Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice
- (2009) Matheus Santos de Sá et al. PARASITOLOGY RESEARCH
- Heat shock protein 90 inhibition is cytotoxic to primary AML cells expressing mutant FLT3 and results in altered downstream signalling
- (2008) Laila Al Shaer et al. BRITISH JOURNAL OF HAEMATOLOGY
- An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models
- (2008) Udai Banerji et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- The heat shock protein antagonist 17-AAG potentiates the activity of enzastaurin against malignant human glioma cells
- (2008) Esther P. Jane et al. CANCER LETTERS
- Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Metastatic Melanoma
- (2008) D. B. Solit et al. CLINICAL CANCER RESEARCH
- A Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Hormone-Refractory Metastatic Prostate Cancer
- (2008) E. I. Heath et al. CLINICAL CANCER RESEARCH
- A Phase I Study of 17-Allylamino-17-Demethoxygeldanamycin Combined with Paclitaxel in Patients with Advanced Solid Malignancies
- (2008) S. S. Ramalingam et al. CLINICAL CANCER RESEARCH
- VIP-grafted sterically stabilized phospholipid nanomicellar 17-allylamino-17-demethoxy geldanamycin: A novel targeted nanomedicine for breast cancer
- (2008) H ONYUKSEL et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- A Cremophor-Free Formulation for Tanespimycin (17-AAG) Using PEO-b-PDLLA Micelles: Characterization and Pharmacokinetics in Rats
- (2008) May P. Xiong et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- 17-Allylamino-17-Demethoxygeldanamycin Down-Regulates Hyaluronic Acid-Induced Glioma Invasion by Blocking Matrix Metalloproteinase-9 Secretion
- (2008) M.-S. Kim et al. MOLECULAR CANCER RESEARCH
- Cisplatin abrogates the geldanamycin-induced heat shock response
- (2008) Andrea K. McCollum et al. MOLECULAR CANCER THERAPEUTICS
- Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells
- (2008) Claire Marie-Elisabeth Sauvageot et al. NEURO-ONCOLOGY
- 17-AAG sensitized malignant glioma cells to death-receptor mediated apoptosis
- (2008) Markus David Siegelin et al. NEUROBIOLOGY OF DISEASE
- HSP90 inhibitor 17AAG causes apoptosis in ATRA-resistant acute promyelocytic leukemia cells
- (2007) Paul N. Meyer et al. LEUKEMIA RESEARCH
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started