Article
Biochemistry & Molecular Biology
Isabel Peters, Sylvia Mueller, Claudia Kuechler, Ute Jaeger, Sebastian Drube
Summary: IL-33 induces the activation of signaling pathways in MCs, leading to the production of pro-inflammatory cytokines and allergic reactions. HSP90, which is upregulated during allergic reactions, plays a role in stabilizing cytokine mRNA and facilitating cytokine production. Therefore, targeting HSP90 could be a potential therapeutic intervention for blocking IL-33-mediated inflammatory reactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zundong Liu, Xiaolin Sang, Min Wang, Yichao Liu, Jiao Liu, Xuefei Wang, Pixu Liu, Hailing Cheng
Summary: Complete blockade of HER2 protein and its signaling network is crucial for effective HER2-targeted therapies. Melatonin plays a role in diminishing HER2 signaling by destroying HER2 protein, enhancing the cytotoxic effects of HER2 inhibitors. Dual inhibition of HER2 using Melatonin and Neratinib effectively blocks the growth of HER2(+) breast tumor xenografts in vivo, indicating a potential novel strategy for HER2(+) breast cancer treatment.
Review
Chemistry, Physical
S. Nisha Raj, E. S. Anooj, Karthikeyan Rajendran, Sugumari Vallinayagam
Summary: Nanotechnology has gained attention for its potential applications in agriculture, leading to the development of nanoagrochemicals to improve efficiency and eco-friendliness. Despite facing challenges, nanoagrochemicals are expected to provide more effective solutions for agricultural production.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biochemistry & Molecular Biology
Lili Chen, Nanami Fujisawa, Masato Takanohashi, Mazaya Najmina, Koichiro Uto, Mitsuhiro Ebara
Summary: This study demonstrates the rational fabrication of a magnetic composite nanofiber mesh that exhibits distinct hyperthermia, enhanced chemotherapeutic efficiency, and thermo-molecularly targeted therapy for potent therapeutic effects in cancer treatment. The nanofiber system represents a smart approach for localized medication delivery and may offer a new strategy for advanced cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yong Jin Oh, Sun You Park, Young Ho Seo
Summary: The development of a hydrogen peroxide-activated Hsp90 inhibitor shows promise in selectively targeting cancer cells while minimizing toxicity effects. This novel approach offers an improved therapeutic index and reduced adverse effects, demonstrating potential for clinical application.
BIOORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Ambreen Shoaib, Shamama Javed, Shadma Wahab, Lubna Azmi, Mohammad Tabish, Muhammad H. Sultan, Karim Abdelsalam, Saad S. Alqahtani, Md Faruque Ahmad
Summary: The goal of antiviral agent research is to find a drug that can reduce viral growth without harming healthy cells. Current challenges include virus transformations, new strain developments, viral resistance, and side effects. It is crucial to discover a natural antiviral agent that can destroy viruses without causing resistance or unintended side effects.
Review
Chemistry, Medicinal
Lei Wang, Qiuyue Zhang, Qidong You
Summary: Heat shock protein 90 (HSP90) is crucial in cancer cells, but its inhibitors have limited efficacy and side effects. Researchers are investigating the disruption of the HSP90-CDC37-kinase complex as an alternative solution to avoid limitations.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Oncology
Muneeb U. Rehman, Andleeb Khan, Zuha Imtiyaz, Shafat Ali, Hafiz Antar Makeen, Summya Rashid, Azher Arafah
Summary: Cancer is a major cause of death worldwide, and nanomedicine has the potential to revolutionize cancer treatment. Nanotechnology allows for the development of specific drugs that target cancer cells and increase drug bioavailability. This review article discusses the advances in nanomedicine and the current clinical status of various nanomedicines, as well as their mechanisms of action.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Matthew C. Phillips, Shaker A. Mousa
Summary: This review focuses on the safety and efficacy of nanoformulated chemotherapeutic agents in clinical trials, with a particular emphasis on anthracyclines, taxanes, and platinum compounds. Nano-based drug-delivery systems have the potential to improve efficacy and reduce adverse effects by targeting chemotherapy.
Review
Engineering, Biomedical
Thenapakiam Sathasivam, Jing Kai, Sigit Sugiarto, Yong Yu, Debbie Xiang Yun Soo, Qiang Zhu, Jasmeen Merzaban, Dan Kai
Summary: This review summarizes the latest developments in nanolignin (NL)-based biomaterials for cancer therapy. Various NL applications related to cancer therapy, including drug and gene delivery, biosensing, bioimaging, and tissue engineering, are considered. The manuscript also discusses the potential use of NL-based materials to improve the therapeutic potency of chemotherapeutic drugs by decreasing their dose and reducing their adverse effects. Moreover, the challenges in the utilization of NL-based materials for cancer therapy are discussed, along with the prospects of advances in such nanomaterials for medical research applications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
M. Joyce Nirmala, Uma Kizhuveetil, Athira Johnson, G. Balaji, Ramamurthy Nagarajan, Vignesh Muthuvijayan
Summary: Cancer is a dangerous disease with high mortality and limited treatment options. Nanomedicine offers a promising alternative due to its targeting capabilities and low toxicity. Various types of nanoparticles have been developed for cancer treatment and newer techniques involving extracellular vesicles and thermal nanomaterials are also being investigated. This review provides insights into the evolution, current status, and prospects of nanomedicine cancer studies.
Article
Chemistry, Multidisciplinary
Yu Wang, Shuting Chen, Jingyi Zhang, Qing Ye, Yin Liu
Summary: DNA nanomaterials, as a novel type of nanomaterials, have great potential in biomedical applications due to their high precision, controllability, and biocompatibility. Therapeutic drugs based on DNA nanomaterials have shown beneficial effects on various diseases. However, the instability of DNA nanomaterials greatly hinders their clinical application. In this study, we designed and synthesized a stable topological DNA nanostructure, DNA Nano Trihedron (DNT), which could enter MCF-7 cells without a transfection agent. DNT induced significant changes in gene expression and exhibited significant inhibitory effects on MCF-7 cells. Even after two months of storage, DNT still retained its inhibitory effect on MCF-7 cells.
Article
Engineering, Biomedical
Chuling Hu, Fenfen Gu, Chunai Gong, Qingming Xia, Yuan Gao, Shen Gao
Summary: Resistance to apoptosis in cancer cells can be overcome by inhibiting autophagy, as demonstrated in this study through the delivery of DOX-EMCH and si-Beclin1 using Co-PMs. The Co-PMs not only enhanced the cytotoxicity and proapoptotic ability in prostate cancer cells, but also showed passive targeting to tumor tissues, resulting in a significant antiproliferative effect in vivo. This suggests that the developed Co-PMs have the potential to combine autophagy inhibition and chemotherapy for effective cancer treatment, particularly in prostate cancer.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Fatemeh Davodabadi, Mohammad Sarhadi, Javad Arabpour, Saman Sargazi, Abbas Rahdar, Ana M. Diez-Pascual
Summary: Breast cancer is a highly heterogeneous disease with four primary molecular subtypes. BC therapeutic vaccines, when used alone or combined with other immunotherapies, have emerged as a promising class of cancer immunotherapeutics. In recent years, nanomedicine has provided new opportunities to enhance the effectiveness of breast cancer vaccinations, with various nanostructures designed to efficiently deliver vaccines to breast cancer cells.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Materials Science, Multidisciplinary
Gang Chen, Yuna Qian, Hang Zhang, Aftab Ullah, Xiaojun He, Zaigang Zhou, Hicham Fenniri, Jianliang Shen
Summary: Nanotechnologies offer potential solutions to the obstacles in cancer therapy, with hybrid nanomaterials showing great promise in a wide range of potential applications for cancer treatment. By combining the unique properties of different classes of nanomaterials, versatile new nanomaterials can be created to target and kill tumor tissues and cells synergistically.
APPLIED MATERIALS TODAY
(2021)
Article
Cell & Tissue Engineering
Vivekanandan Palaninathan, Sreejith Raveendran, Ankit K. Rochani, Neha Chauhan, Yasushi Sakamoto, Tomofumi Ukai, Toru Maekawa, D. Sakthi Kumar
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2018)
Article
Chemistry, Multidisciplinary
Srishti Agarwal, M. Sheikh Mohamed, Sreejith Raveendran, Ankit K. Rochani, Toru Maekawa, D. Sakthi Kumar
Article
Materials Science, Multidisciplinary
T. Sakai, M. Sakai, T. Kobayashi, M. Yasutake, S. Akisato, R. Mikami, N. Suganuma, Y. Takahashi, Y. Nakajima, M. Tokuda, Y. Fujii, T. Hanajiri, O. Nakamura
Article
Pharmacology & Pharmacy
Edwin Lam, Ankit Rochani, Gagan Kaushal, Brandi N. Thoma, Julian Tanjuakio, Frances Mae West, Hitoshi Hirose
CLINICAL THERAPEUTICS
(2019)
Article
Physics, Applied
A. T. M. Saiful Islam, Md. Enamul Karim, Arifuzzaman Rajib, Yuki Nasuno, Tomofumi Ukai, Shunji Kurosu, Masahide Tokuda, Yasuhiko Fujii, Yoshikata Nakajima, Tatsuro Hanajiri, Hajime Shirai
APPLIED PHYSICS LETTERS
(2019)
Article
Multidisciplinary Sciences
Hideki Kobayashi, Hirokazu Shimoshige, Yoshikata Nakajima, Wataru Arai, Hideto Takami
Article
Chemistry, Analytical
Ankit Rochani, Edwin Lam, Julian Tanjuakio, Hitoshi Hirose, Walter K. Kraft, Gagan Kaushal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2020)
Article
Nanoscience & Nanotechnology
Ankita Borah, Sindhu C. Pillai, Ankit K. Rochani, Vivekanandan Palaninathan, Yoshikata Nakajima, Toru Maekawa, D. Sakthi Kumar
Article
Physics, Applied
N. Keswani, Y. Nakajima, N. Chauhan, T. Ukai, H. Chakraborti, K. D. Gupta, T. Hanajiri, S. Kumar, Y. Ohno, H. Ohno, P. Das
APPLIED PHYSICS LETTERS
(2020)
Article
Multidisciplinary Sciences
Neeti Keswani, Ricardo J. C. Lopes, Yoshikata Nakajima, Ranveer Singh, Neha Chauhan, Tapobrata Som, D. Sakthi Kumar, Afranio R. Pereira, Pintu Das
Summary: Through the control of external magnetic fields, we have demonstrated the stabilization of isolated emergent monopole-like magnetically charged vertices in individual square artificial spin ice systems. This excitation conserves the magnetic charge without involving an excitation of opposite charge. Our experimental results, well supported by Monte Carlo simulations, allow for the creation of electron vortices and the study of electrodynamics in the presence of a monopole-like field in a solid state environment in the absence of a true elemental magnetic monopole.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Electrical & Electronic
Yudai Nakanishi, Yusuke Hayashi, Takeaki Hamachi, Tetsuya Tohei, Yoshikata Nakajima, Shiyu Xiao, Kanako Shojiki, Hideto Miyake, Akira Sakai
Summary: The micro- and nanostructures in vapor-phase-grown AlN on face-to-face annealed sputtered AlN templates formed on nanopatterned sapphire substrates were studied using transmission electron microscopy. The comparison between two different growth methods showed distinct differences in dislocation propagation, presence of voids, shape of polarity inversion boundaries, and crystal structures on the slope region of the substrate. The quality of the annealed sputtered AlN significantly influenced the threading dislocation density in the grown layer. This study provides practical information for controlling the micro- and nanostructures in AlN/nanopatterned sapphire substrate structures for high-performance deep-ultraviolet emitters.
JOURNAL OF ELECTRONIC MATERIALS
(2023)
Article
Physics, Multidisciplinary
Kaname Sato, Yutaro Takahashi, Shujiro Akisato, Ryota Mikami, Nao Suganuma, Yugo Ashizawa, Hayate Kawaguchi, Yoshikata Nakajima, Tomofumi Ukai, Yasuhiko Fuji, Tatsuro Hanajiri, Junya Kaneko, Osamu Nakamura, Pham Van Thach, Hiroyuki Awano, Shigehiko Hasegawa, Masamichi Sakai
Summary: Spin-charge coupling plays a crucial role in spintronics and can be categorized into bulk characteristic via spin-orbit interaction or interfacial characteristic provided by a junction of magnetic and nonmagnetic conductors. In this study, we explore the spin-charge coupling characteristics of a lateral junction composed of a rare-earth transition metal ferrimagnet and a compensated metal. Our results show that the inverse spin Hall effect significantly contributes to the transverse resistance. Additionally, we formulate a minimal expression of the transverse resistance for out-of-plane-polarized electron and hole spin currents injected from the magnetic electrode.
Article
Chemistry, Physical
Sreejith Raveendran, Anindito Sen, Toru Maekawa, D. Sakthi Kumar
Summary: The study explores the deleterious effects of therapeutic gold nanocages on the subcellular organelles of MCF7 cells, demonstrating significant localization of the nanocarriers within specific organelles leading to their destruction within 96 hours.
Article
Materials Science, Multidisciplinary
Neeti Keswani, Ranveer Singh, Yoshikata Nakajima, Tapobrata Som, Pintu Das
Article
Chemistry, Multidisciplinary
Sreejith Raveendran, Anindito Sen, Hiromi Ito-Tanaka, Kazunori Kato, Toru Maekawa, D. Sakthi Kumar
NANOSCALE ADVANCES
(2019)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
