Megakaryocytic dysfunction in immune thrombocytopenia is linked to autophagy

Aggregation is impaired in starved platelets due to enhanced autophagy and cellular energy depletion

(2018) Manoj Paul et al.   PLATELETS

The Autophagy-Lysosomal Pathways and Their Emerging Roles in Modulating Proteostasis in Tumors

(2018) Zhen Dong et al.   Cells

Induced Pluripotent Stem Cell Neuronal Models for the Study of Autophagy Pathways in Human Neurodegenerative Disease

(2017) Natalia Jiménez-Moreno et al.   Cells

Targeting autophagy as a potential therapeutic approach for immune thrombocytopenia therapy

(2016) Ning-ning Shan et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis

(2016) Qi Wang et al.   PLATELETS

Impaired Autophagy in Adult Bone Marrow CD34+ Cells of Patients with Aplastic Anemia: Possible Pathogenic Significance

(2016) Jinbo Huang et al.   PLoS One

Choose Delicately and Reuse Adequately: The Newly Revealed Process of Autophagy

(2015) Satoru Kobayashi   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Update on the role of autophagy in systemic lupus erythematosus: A novel therapeutic target

(2015) Qingjun Pan et al.   BIOMEDICINE & PHARMACOTHERAPY

Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis

(2015) M. M. Ouseph et al.   BLOOD

Biologicals, platelet apoptosis and human diseases: An outlook

(2015) R.M. Thushara et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Loss of autophagy leads to failure in megakaryopoiesis, megakaryocyte differentiation, and thrombopoiesis in mice

(2015) Yan Cao et al.   EXPERIMENTAL HEMATOLOGY

The effects of panaxadiol saponins on megakaryocytic maturation and immune function in a mouse model of immune thrombocytopenia

(2015) Xiaojie Lin et al.   EXPERIMENTAL HEMATOLOGY

Autophagy in autoimmune disease

(2015) Zhen Yang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Low-dose decitabine promotes megakaryocyte maturation and platelet production in healthy controls and immune thrombocytopenia

(2015) Hai Zhou et al.   THROMBOSIS AND HAEMOSTASIS

Dynamics and function of PtdIns(3)Pin autophagy

(2014) Keisuke Obara et al.   Autophagy

Selective mitochondrial autophagy during erythroid maturation

(2014) Min Chen et al.   Autophagy

Structural insights into E2–E3 interaction for LC3 lipidation

(2014) Zoltan Metlagel et al.   Autophagy

Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice

(2014) XiuJie Li-Harms et al.   BLOOD

Recent insights on the putative role of autophagy in autoimmune diseases

(2013) Elena Gianchecchi et al.   AUTOIMMUNITY REVIEWS

Born to survive: Autophagy in hematopoietic stem cell maintenance

(2013) Matthew R. Warr et al.   CELL CYCLE

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

The incredible journey: From megakaryocyte development to platelet formation

(2013) Kellie R. Machlus et al.   JOURNAL OF CELL BIOLOGY

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

New Fundamentals in Hemostasis

(2013) Henri H. Versteeg et al.   PHYSIOLOGICAL REVIEWS

Autophagy Plays an Essential Role in Mediating Regression of Hypertrophy during Unloading of the Heart

(2013) Nirmala Hariharan et al.   PLoS One

Autophagy in immunity

(2012) Xu-Jie Zhou et al.   Autophagy

Macroautophagy is deregulated in murine and human lupus T lymphocytes

(2012) Frédéric Gros et al.   Autophagy

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Metabolic regulation of organelle homeostasis in lupus T cells

(2012) Tiffany N. Caza et al.   CLINICAL IMMUNOLOGY

Proliferation signal inhibitors in the treatment of lupus nephritis: Preliminary experience

(2012) DESMOND YH YAP et al.   NEPHROLOGY

An Overview of Autophagy and Yeast Pseudohyphal Growth: Integration of Signaling Pathways during Nitrogen Stress

(2012) Qingxuan Song et al.   Cells

Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population

(2011) X.-j. Zhou et al.   ANNALS OF THE RHEUMATIC DISEASES

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Chasing the elusive mammalian microautophagy

(2011) Laura Santambrogio et al.   Autophagy

Autophagy is required for self-renewal and differentiation of adult human stem cells

(2011) Souzan Salemi et al.   CELL RESEARCH

Autophagy: for better or for worse

(2011) Ellen Wirawan et al.   CELL RESEARCH

Autophagy in immunity and cell-autonomous defense against intracellular microbes

(2011) Vojo Deretic   IMMUNOLOGICAL REVIEWS

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

(2011) Monika Mortensen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells

(2011) Jamie M. Ireland et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

The role of neutrophils in SLE: untangling the NET

(2011) Nick Warde   Nature Reviews Rheumatology

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Antigen processing via autophagy—not only for MHC class II presentation anymore?

(2010) Christian Münz   CURRENT OPINION IN IMMUNOLOGY

The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis

(2010) Craig M. Walsh et al.   IMMUNOLOGICAL REVIEWS

Genetic variation in the autophagy gene ULK1 and risk of Crohnʼs disease

(2010) Liesbet Henckaerts et al.   INFLAMMATORY BOWEL DISEASES

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line

(2009) Pascal Colosetti et al.   Autophagy

Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis

(2009) Mehrdad Alirezaei et al.   Autophagy

Autophagy in cells of the blood

(2009) Shida Yousefi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

International consensus report on the investigation and management of primary immune thrombocytopenia

(2009) D. Provan et al.   BLOOD

AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

(2009) C. M. Chresta et al.   CANCER RESEARCH

Distinct roles of the mTOR components Rictor and Raptor in MO7e megakaryocytic cells

(2009) Gwenny M. Fuhler et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Regulation of megakaryocyte maturation and platelet formation

(2009) D. BLUTEAU et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Erythroid precursors from patients with low-risk myelodysplasia demonstrate ultrastructural features of enhanced autophagy of mitochondria

(2009) E J Houwerzijl et al.   LEUKEMIA

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

(2009) M. Mortensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review

(2008) G Ruiz-Irastorza et al.   ANNALS OF THE RHEUMATIC DISEASES

Control of autophagy by oncogenes and tumor suppressor genes

(2008) M C Maiuri et al.   CELL DEATH AND DIFFERENTIATION

mTOR Pathway and mTOR Inhibitors as Agents for Cancer Therapy

(2008) Paolo Baldo et al.   CURRENT CANCER DRUG TARGETS

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

(2008) U. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice

(2008) S. L. Lui et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis

(2008) Padmalatha S Reddy et al.   ARTHRITIS RESEARCH & THERAPY