MicroRNA-196a is regulated by ER and is a prognostic biomarker in ER+ breast cancer

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples

(2018) Han Chen et al.   CELL

Estrogen-induced miR-196a elevation promotes tumor growth and metastasis via targeting SPRED1 in breast cancer

(2018) Cheng-Fei Jiang et al.   Molecular Cancer

Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer

(2018) Darren K. Patten et al.   NATURE MEDICINE

JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework

(2017) Aziz Khan et al.   NUCLEIC ACIDS RESEARCH

Superenhancer reprogramming drives a B-cell–epithelial transition and high-risk leukemia

(2016) Yeguang Hu et al.   GENES & DEVELOPMENT

Long-range regulators of the lncRNAHOTAIRenhance its prognostic potential in breast cancer

(2016) Michael J.G. Milevskiy et al.   HUMAN MOLECULAR GENETICS

Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer

(2016) Dong-Xu He et al.   Scientific Reports

Motor neuron-expressed microRNAs 218 and their enhancers are nested within introns ofSlit2/3genes

(2015) Beena Punnamoottil et al.   GENESIS

MicroRNA Therapeutics: the Next Magic Bullet?

(2015) Bridget Simonson et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

TNFα Signaling Exposes Latent Estrogen Receptor Binding Sites to Alter the Breast Cancer Cell Transcriptome

(2015) Hector L. Franco et al.   MOLECULAR CELL

Multiplexed analysis of chromosome conformation at vastly improved sensitivity

(2015) James O J Davies et al.   NATURE METHODS

DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer

(2015) Andrew Stone et al.   Nature Communications

Epigenetic and transcriptional determinants of the human breast

(2015) Philippe Gascard et al.   Nature Communications

MicroRNA-196a promotes cervical cancer proliferation through the regulation of FOXO1 and p27Kip1

(2014) T Hou et al.   BRITISH JOURNAL OF CANCER

The complexity of miRNA-mediated repression

(2014) A Wilczynska et al.   CELL DEATH AND DIFFERENTIATION

Enhancer Malfunction in Cancer

(2014) Hans-Martin Herz et al.   MOLECULAR CELL

The UCSC Genome Browser database: 2015 update

(2014) Kate R. Rosenbloom et al.   NUCLEIC ACIDS RESEARCH

Microprocessor Activity Controls Differential miRNA Biogenesis In Vivo

(2014) Thomas Conrad et al.   Cell Reports

Enhancer alterations in cancer: a source for a cell identity crisis

(2014) Ken J Kron et al.   Genome Medicine

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

Antisense Transcript Long Noncoding RNA (lncRNA) HOTAIR is Transcriptionally Induced by Estradiol

(2013) Arunoday Bhan et al.   JOURNAL OF MOLECULAR BIOLOGY

The perimenopausal woman: Endocrinology and management

(2013) Georgina E. Hale et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

A new method for stranded whole transcriptome RNA-seq

(2013) David F.B. Miller et al.   METHODS

The shaping and functional consequences of the microRNA landscape in breast cancer

(2013) Heidi Dvinge et al.   NATURE

Identification of an Enhancer That Increases miR-200b~200a~429 Gene Expression in Breast Cancer Cells

(2013) Joanne L. Attema et al.   PLoS One

Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory Factor

(2013) Hisham Mohammed et al.   Cell Reports

MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5

(2012) Xiang-hua Liu et al.   BMC CANCER

Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation

(2012) Guoliang Li et al.   CELL

Elucidating Prognosis and Biology of Breast Cancer Arising in Young Women Using Gene Expression Profiling

(2012) Hatem A. Azim et al.   CLINICAL CANCER RESEARCH

Building a Robust A-P Axis

(2012) Alysha Heimberg et al.   CURRENT GENOMICS

MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review

(2012) Marilena V. Iorio et al.   EMBO Molecular Medicine

MiR-196a Is Upregulated in Gastric Cancer and Promotes Cell Proliferation by Downregulating p27kip1

(2012) M. Sun et al.   MOLECULAR CANCER THERAPEUTICS

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

(2012) Caryn S. Ross-Innes et al.   NATURE

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Single Nucleotide Polymorphism in hsa-mir-196a-2 and Breast Cancer Risk: A Case Control Study

(2012) Dominik J. Jedlinski et al.   Twin Research and Human Genetics

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

A Rapid, Extensive, and Transient Transcriptional Response to Estrogen Signaling in Breast Cancer Cells

(2011) Nasun Hah et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

HOXC6 Is Transcriptionally Regulated via Coordination of MLL Histone Methylase and Estrogen Receptor in an Estrogen Environment

(2011) Khairul I. Ansari et al.   JOURNAL OF MOLECULAR BIOLOGY

HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4

(2011) Khairul I Ansari et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

PBX1 Genomic Pioneer Function Drives ERα Signaling Underlying Progression in Breast Cancer

(2011) Luca Magnani et al.   PLoS Genetics

Estrogen Receptors Bind to and Activate theHOXC4/HoxC4Promoter to Potentiate HoxC4-mediated Activation-induced Cytosine Deaminase Induction, Immunoglobulin Class Switch DNA Recombination, and Somatic Hypermutation

(2010) Thach Mai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXA1 is a key determinant of estrogen receptor function and endocrine response

(2010) Antoni Hurtado et al.   NATURE GENETICS

FOXM1 is a transcriptional target of ERα and has a critical role in breast cancer endocrine sensitivity and resistance

(2010) J Millour et al.   ONCOGENE

RNA Polymerase II Binding Patterns Reveal Genomic Regions Involved in MicroRNA Gene Regulation

(2010) Guohua Wang et al.   PLoS One

Long-range enhancers on 8q24 regulate c-Myc

(2010) J. Sotelo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

microRNA miR-196a-2 and Breast Cancer: A Genetic and Epigenetic Association Study and Functional Analysis

(2009) A. E. Hoffman et al.   CANCER RESEARCH

ChIP-Seq of ERα and RNA polymerase II defines genes differentially responding to ligands

(2009) Willem-Jan Welboren et al.   EMBO JOURNAL

Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13

(2009) Khairul I. Ansari et al.   FEBS Journal

Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues

(2009) Angela B Y Hui et al.   LABORATORY INVESTIGATION

An oestrogen-receptor-α-bound human chromatin interactome

(2009) Melissa J. Fullwood et al.   NATURE

Features of Mammalian microRNA Promoters Emerge from Polymerase II Chromatin Immunoprecipitation Data

(2009) David L. Corcoran et al.   PLoS One

In ovo application of antagomiRs indicates a role for miR-196 in patterning the chick axial skeleton through Hox gene regulation

(2009) E. McGlinn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women

(2008) Zhibin Hu et al.   HUMAN MUTATION

The Menopausal Transition—Endocrinology

(2008) Henry Burger   Journal of Sexual Medicine

MicroRNAs in the Hox network: an apparent link to posterior prevalence

(2008) Soraya Yekta et al.   NATURE REVIEWS GENETICS

MicroRNA-196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 downregulation in cancers

(2008) R Luthra et al.   ONCOGENE

Dynamic interactions between the promoter and terminator regions of the mammalianBRCA1gene

(2008) Sue Mei Tan-Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY