BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology

Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6

(2018) Kaichuan Zhu et al.   BIOLOGICAL PSYCHIATRY

BACE inhibition-dependent repair of Alzheimer’s pathophysiology

(2017) Aylin D. Keskin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High plasticity of axonal pathology in Alzheimer’s disease mouse models

(2017) Lidia Blazquez-Llorca et al.   Acta Neuropathologica Communications

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease

(2016) Katherine R. Sadleir et al.   ACTA NEUROPATHOLOGICA

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

The BACE1 inhibitor verubecestat (MK-8931) reduces CNS  -amyloid in animal models and in Alzheimers disease patients

(2016) M. E. Kennedy et al.   Science Translational Medicine

Early changes in CSF sTREM2 in dominantly inherited Alzheimers disease occur after amyloid deposition and neuronal injury

(2016) M. Suarez-Calvet et al.   Science Translational Medicine

Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions

(2015) Severin Filser et al.   BIOLOGICAL PSYCHIATRY

Beneficial Effects of the β-Secretase Inhibitor GRL-8234 in 5XFAD Alzheimer’s Transgenic Mice Lessen During Disease Progression

(2015) Latha Devi et al.   Current Alzheimer Research

Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice

(2015) D. R. Thakker et al.   JOURNAL OF NEUROSCIENCE

The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central A  Pharmacodynamic Responses in Mice, Dogs, and Humans

(2015) P. C. May et al.   JOURNAL OF NEUROSCIENCE

Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level

(2015) Katherine R Sadleir et al.   Molecular Neurodegeneration

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

(2015) Ulf Neumann et al.   Molecular Neurodegeneration

Effects of BACE1 haploinsufficiency on APP processing and Aβ concentrations in male and female 5XFAD Alzheimer mice at different disease stages

(2015) L. Devi et al.   NEUROSCIENCE

Lessons from a BACE1 inhibitor trial: Off-site but not off base

(2014) Debomoy K. Lahiri et al.   Alzheimers & Dementia

Lessons from a Failed γ-Secretase Alzheimer Trial

(2014) Bart De Strooper   CELL

Combined Treatment with a BACE Inhibitor and Anti-A  Antibody Gantenerumab Enhances Amyloid Reduction in APPLondon Mice

(2014) H. Jacobsen et al.   JOURNAL OF NEUROSCIENCE

In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques

(2014) Steffen Burgold et al.   Acta Neuropathologica Communications

Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer’s disease

(2013) Joanna F. McCarter et al.   ACTA NEUROPATHOLOGICA

The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

(2013) Patty C. Kandalepas et al.   ACTA NEUROPATHOLOGICA

Elevated Aβ42 in Aged, Non-demented Individuals with Cerebral Atherosclerosis

(2013) Katherine Sadleir et al.   Current Alzheimer Research

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles

(2013) Cyril Cheret et al.   EMBO JOURNAL

Increased Expression of Reticulon 3 in Neurons Leads to Reduced Axonal Transport of β Site Amyloid Precursor Protein-cleaving Enzyme 1

(2013) Minzi Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Fluid Biomarkers in Alzheimer Disease

(2013) K. Blennow et al.   Cold Spring Harbor Perspectives in Medicine

Amyloid plaque formation precedes dendritic spine loss

(2012) Tobias Bittner et al.   ACTA NEUROPATHOLOGICA

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

(2012) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer’s Disease and Beyond

(2012) Bastian Dislich et al.   Frontiers in Physiology

In Vivo Imaging of Intersynaptic Vesicle Exchange Using VGLUT1Venus Knock-In Mice

(2011) E. Herzog et al.   JOURNAL OF NEUROSCIENCE

Long-Term In Vivo Imaging of  -Amyloid Plaque Appearance and Growth in a Mouse Model of Cerebral  -Amyloidosis

(2011) J. K. Hefendehl et al.   JOURNAL OF NEUROSCIENCE

Robust Central Reduction of Amyloid-  in Humans with an Orally Available, Non-Peptidic  -Secretase Inhibitor

(2011) P. C. May et al.   JOURNAL OF NEUROSCIENCE

In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks

(2010) Steffen Burgold et al.   ACTA NEUROPATHOLOGICA

β-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice

(2010) Wan-Pin Chang et al.   FASEB JOURNAL

A Noncompetitive BACE1 Inhibitor TAK-070 Ameliorates A  Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease

(2010) H. Fukumoto et al.   JOURNAL OF NEUROSCIENCE

Amyloid β-Protein Aggregation Produces Highly Reproducible Kinetic Data and Occurs by a Two-Phase Process

(2009) Erik Hellstrand et al.   ACS Chemical Neuroscience

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

β-Secretase-1 elevation in transgenic mouse models of Alzheimer’s disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development

(2009) Xue-Mei Zhang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Molecular insights into  -galactoside  2,6-sialyltransferase secretion in vivo

(2009) S. Kitazume et al.   GLYCOBIOLOGY

β-Secretase Inhibitor Potency Is Decreased by Aberrant β-Cleavage Location of the “Swedish Mutant” Amyloid Precursor Protein

(2009) Hidekuni Yamakawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Secretase Inhibition Reduces Spine Density In Vivo via an Amyloid Precursor Protein-Dependent Pathway

(2009) T. Bittner et al.   JOURNAL OF NEUROSCIENCE

Characterizing the Appearance and Growth of Amyloid Plaques in APP/PS1 Mice

(2009) P. Yan et al.   JOURNAL OF NEUROSCIENCE

Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window

(2009) Anthony Holtmaat et al.   Nature Protocols

Worldwide variation in the doubling time of Alzheimer's disease incidence rates

(2008) Kathryn Ziegler-Graham et al.   Alzheimers & Dementia

Widespread Changes in Dendritic Spines in a Model of Alzheimer's Disease

(2008) S. Knafo et al.   CEREBRAL CORTEX

γ-Secretase Inhibition and Modulation for Alzheimers Disease

(2008) Michael Wolfe   Current Alzheimer Research