Article
Immunology
Andres Fernandez, Elena Quintana, Patricia Velasco, Belen Moreno-Jimenez, Belen de Andres, Maria Luisa Gaspar, Isabel Liste, Marcal Vilar, Helena Mira, Eva Cano
Summary: The study found that aged SAMP8 mice exhibit many features of aging-related neuroinflammation, including increased protein aggregates and elevated levels of inflammatory mediator IL-1 beta. Compared to the control group, SAMP8 mice showed a more significant neuroinflammatory response.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Plant Sciences
Yue-Hu Wang
Summary: The study summarized the traditional uses of leaves from 16 Dendrobium species, revealing their effectiveness in treating dermatologic disorders, metabolic syndromes, nervous system disorders, and musculoskeletal system disorders. More than 50 chemical compounds have been identified in the leaves, showing various pharmacological activities. Among Dendrobium species, D. officinale leaves are the most extensively studied.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Xiaoyang Zhang, Yanfeng Yan, Yunxia Lv, Xin Li, Leiyao Chen, Zihui Huang, Junbo Zhou, Yong Wang, Xiaoming Wang, Xu Wang, Hongwei Gu
Summary: Urinary tract infections (UTI) caused by uropathogenic Escherichia coli (UPEC) can be attenuated by Dendrobium officinale polysaccharides (DOPs), which possess anti-inflammatory properties and inhibit the activation of NLRP3 pathway and ROS signal. DOPs effectively mitigate UPEC-induced pyroptosis in macrophage cells by reducing cell damage and pro-inflammatory cytokine secretion.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Food Science & Technology
Chuanbo Sun, Nuo Zhang, Guangpei Xu, Ping Jiang, Shiping Huang, Qun Zhao, Yanfei He
Summary: This study demonstrates that Dendrobium officinale polysaccharides (DOP) have antitumor and immunomodulatory activities, inhibiting tumor growth through multiple pathways.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Nutrition & Dietetics
Nkwachukwu Oziamara Okoro, Arome Solomon Odiba, Qi Yu, Bin He, Guiyan Liao, Cheng Jin, Wenxia Fang, Bin Wang
Summary: Dendrobium officinale, a widely used medicinal herb, has gained attention for its polysaccharide content and its potential medicinal properties. In this study, the anti-aging potential of polysaccharides extracted from D. officinale grown in different environments was investigated using Caenorhabditis elegans as a model. The findings showed that greenhouse-grown D. officinale polysaccharides had the optimal effect of extending lifespan and enhancing stress resistance. These results provide valuable information for the cultivation and medicinal applications of D. officinale.
Article
Geriatrics & Gerontology
Bo Liu, Ling-li Lv, Ping Liu, Yun-Yan Xu, Mian Guo, Jie Liu, Jing-Shan Shi
Summary: This study investigated the anti-aging effects of Dendrobium nobile alkaloids (DNLA) on cognitive deficits and neuron loss in Senescence-accelerated mouse prone 8 (SAMP8) mice. DNLA improved cognitive dysfunction and ameliorated neuronal injury in aged SAMP8 mice through the regulation of protein/gene expressions related to Alzheimer's disease.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Food Science & Technology
Qiu-Ping Zhang, Jie Cheng, Qing Liu, Guang-Hui Xu, Cheng-Fu Li, Li-Tao Yi
Summary: Dendrobium officinale polysaccharides (DOP) can alleviate perimenopausal depression symptoms by modulating gut microbiota-neuroinflammation and restoring the hypothalamic-pituitary-adrenal (HPA) axis.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Biochemistry & Molecular Biology
Wen-hua Chen, Jian-jun Wu, Xue-fei Li, Jie-miao Lu, Wei Wu, Yi-qi Sun, Bo Zhu, Lu-ping Qin
Summary: Dendrobium officinale polysaccharides exhibit a variety of biological effects, including immunomodulatory, anti-tumor, and gastro-protective effects. Further research is needed to explore extraction, purification, and structural characteristics of these polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Hang Chen, Xueqin Shi, Lanyan Cen, Lin Zhang, Yifeng Dai, Shuyi Qiu, Xiangyong Zeng, Chaoyang Wei
Summary: In this study, different fermentations were conducted on Dendrobium officinale polysaccharides, and it was found that yeast fermentation could effectively reduce the molecular weight and improve the antioxidant activity of the polysaccharides, indicating a potential way to enhance their antioxidant activity. Additionally, four homogeneous polysaccharides with different compositions and molecular weights were obtained. These findings are significant for further research on Dendrobium officinale polysaccharides.
Article
Environmental Sciences
Yi Mu, Bangwei Che, Kaifa Tang, Wenjun Zhang, Shenghan Xu, Wei Li, Jun He, Miao Liu, Peng Chen, Siwen Zhong, Guangyu Li
Summary: This study explored the protective effect of Dendrobium officinale polysaccharides (DOPs) on reproductive oxidative stress injury in male mice and its mechanism. The results showed that DOPs effectively reduced the oxidative stress injury of testicular tissue and improved sperm quality and hormone levels. The protective effect of DOPs was mediated by reducing oxidative stress levels, improving the hormone environment in testes, and regulating the expression of specific genes in Sertoli cells and spermatogenic cells.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ming Cai, Hua Zhu, Lei Xu, Jian Wang, Jing Xu, Zhenhao Li, Kai Yang, Jianyong Wu, Peilong Sun
Summary: This study aimed to investigate the antifatigue and prebiotic effects of three ethanol precipitated polysaccharides from Dendrobium officinale (EPDO-40, EPDO-60, and EPDO-80) and their relationships to the structure properties. EPDOs with antifatigue activity were screened through forced swimming test, and various indicators including blood lactic acid (BLA), blood urea nitrogen (BUN), superoxide dismutase (SOD), and gut microflora were examined. The purified EPDO-60, with a molecular weight of 277.3 kDa and a backbone consisting of 4-Manp and 4-Glcp, exhibited the best antifatigue activity by significantly prolonging forced swimming time, reducing BLA and BUN levels, and increasing SOD. Treatment with EPDO-60 also led to an increase in the proportion of Bacteroidetes and Firmicutes and the abundance of Lactobacillus and Bifidobacterium in gut microflora. Therefore, EPDO-60 could influence the community structure of gut microflora, promoting the balance of oxidation and antioxidation, and accelerating fatigue metabolism in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Yingmin Liang, Ruixuan Du, Rui Chen, Pak Hin Chu, Mary Sau Man Ip, Kalin Yan Bo Zhang, Judith Choi Wo Mak
Summary: DOPs extracted from Dendrobium officinale showed therapeutic effects in reducing cigarette smoke-induced airway inflammation by decreasing oxidative stress and inflammatory cell infiltration, as well as inhibiting the activation of MAPK and NF-kappa B signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Li Hao, Xin Shi, Shunwang Qin, Jiahong Dong, Huan Shi, Yuehua Wang, Yi Zhang
Summary: In this study, 25 DoSWEET genes were identified and analyzed in D. officinale. The research revealed the evolutionary relationship, conserved motifs, chromosomal location, and expression patterns of DoSWEETs. Different DoSWEET genes play different roles in sugar transport, and some genes are regulated under stress conditions. The correlation analysis and interaction network prediction provide a foundation for further functional verification.
Article
Food Science & Technology
Chen Li, Yunwei Wang, Zijia Huang, Yi Zhang, Jiao Li, Qing Zhang, Benjamin Kofi Simpson, Jingxue Wang
Summary: This study investigated the hypoglycemic and hypolipidemic effects of polysaccharides of Dendrobium officinale compound (DOCP) on streptozotocin induced type 2 diabetic mice. DOCP significantly decreased fasting blood glucose and insulin resistance, increased serum insulin content, reduced lipid levels, improved antioxidant capability, and protected liver and pancreas. DOCP also increased the diversity of intestinal flora and up-regulated the expression of key genes related to glucose metabolism.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Chemistry, Medicinal
Martina Sutovska, Jozef Mazerik, Michaela Kocmalova, Iveta Uhliarikova, Maria Matulova, Peter Capek
Summary: The study found that Dendrobium polysaccharides have significant antitussive activity and can be used to treat coughing, especially in asthmatics, by bronchodilation and increasing the threshold of cough receptor activation.
ARCHIV DER PHARMAZIE
(2023)
Article
Biochemistry & Molecular Biology
Yangyang Shan, Panmiao Liu, Yanbo Zhou, Xin Ding, Hongtao Liu, Jianjun Yang
Summary: This study reveals the critical role of NLRP3 inflammasome and HMGB1 in sevoflurane-induced cognitive impairment. The results indicate that the HMGB1 inhibitor can suppress the activation of the NLRP3/ASC inflammasome and cognitive dysfunction caused by sevoflurane.
ACS CHEMICAL NEUROSCIENCE
(2023)
Letter
Anesthesiology
Penghui Wei, Haotian Ye, Jianjun Li, Jian-jun Yang
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Editorial Material
Anesthesiology
Haotian Ye, Penghui Wei, Jian-jun Yang
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2023)
Review
Biochemistry & Molecular Biology
Jie Guo, Di Qiu, Han-wen Gu, Xing-ming Wang, Kenji Hashimoto, Guang-fen Zhang, Jian-jun Yang
Summary: The perioperative administration of ketamine reduces postoperative depression and pain scores but increases the risk of adverse effects.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Xingming Wang, Akifumi Eguchi, Yong Yang, Lijia Chang, Xiayun Wan, Jiajing Shan, Youge Qu, Li Ma, Chisato Mori, Jianjun Yang, Kenji Hashimoto
Summary: Multiple sclerosis (MS) is a common demyelinating disease that affects the central nervous system. This study investigated the effects of subdiaphragmatic vagotomy (SDV) on demyelination in cuprizone (CPZ)-treated mice and found that SDV significantly improved demyelination and microglial activation in the brain. Analysis of gut microbiota composition and blood metabolites revealed that SDV also improved the abnormal levels in CPZ-treated mice. These findings suggest a link between the gut microbiota-brain axis and demyelination in the brain.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Endocrinology & Metabolism
Xin-Miao Wu, Yu-Zhu Gao, Ting-Ting Zhu, Han-Wen Gu, Jian-Hua Tong, Jie Sun, Jian-Jun Yang, Mu-Huo Ji
Summary: This study investigated the potential molecular mechanisms of early life inflammation-induced cognitive impairment by conducting proteomic and phosphoproteomic analysis of the hippocampus. It was found that early life lipopolysaccharide (LPS) exposure led to cognitive impairment in male mice but not in female mice. The analysis also revealed that early life LPS exposure affected the glutamatergic synapse and neuroactive ligand-receptor interaction, which are associated with synaptic function and energy metabolism.
NEUROIMMUNOMODULATION
(2023)
Article
Chemistry, Medicinal
Jin-Jin Yang, Lei Lei, Di Qiu, Sai Chen, Jing-Wei Zhao, Yuan -Yuan Mao, Jian-Jun Yang
Summary: This randomized controlled trial aimed to evaluate the relationship between remimazolam and postoperative delirium in older adult patients undergoing orthopedic surgery. The incidence of postoperative delirium in the remimazolam group was 15.6%, while it was 12.4% in the propofol group, with no significant difference observed. Although patients in the remimazolam group had a lower incidence of hypotension and consumed fewer vasoactive drugs intraoperatively, they experienced longer postoperative extubation time and PACU stay.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Medical Informatics
Cheng-Mao Zhou, Ying Wang, Jian-Jun Yang, Yu Zhu
Summary: Machine learning can predict gastric cancer patients' prognosis, but no studies have explored predicting gastric cancer death based on machine learning using related inflammatory factor variables. In this study, six machine learning algorithms were applied to predict total gastric cancer death after surgery, and the neutrophil-lymphocyte ratio, platelet lymphocyte ratio, and age were found to be the most important factors.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2023)
Article
Clinical Neurology
Sai Chen, Jin-Jin Yang, Yue Zhang, Lei Lei, Di Qiu, Hui-Min Lv, Zhen-Tao Sun, Kenji Hashimoto, Jian-Jun Yang
Summary: This study investigated the effects of a single-dose of esketamine during anesthesia induction on emergence delirium (ED) in preschool children after minor surgery. The study found that the use of esketamine was associated with a higher incidence and score of ED, as well as a longer post-anesthesia care unit stay. However, there were no significant differences in other outcomes between the two groups. Therefore, the use of esketamine in preschool children for minor surgery should be noticed.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Xingming Wang, Akifumi Eguchi, Yuko Fujita, Xiayun Wan, Lijia Chang, Yong Yang, Jiajing Shan, Youge Qu, Li Ma, Yukihiko Shirayama, Chisato Mori, Jianjun Yang, Kenji Hashimoto
Summary: This study found that gut microbiota and microbiome-derived metabolites play important roles in susceptibility versus resilience in rats exposed to inescapable electric stress. The relative abundances of Asaccharobacter, Eisenbergiella, and Klebsiella in the gut microbiota of susceptible rats were significantly higher than that of resilient rats. Additionally, several microbiome and metabolites were found to be significantly altered between susceptible and resilient rats.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Immunology
Xiao-Yu Yin, Xiao-Hui Tang, Shi-Xu Wang, Yong-Chang Zhao, Min Jia, Jian-Jun Yang, Mu-Huo Ji, Jin-Chun Shen
Summary: This study found that in sepsis-associated encephalopathy, high mobility group box-1 protein (HMGB1) induces microglial activation-mediated neuroinflammation and cognitive impairment. Modulating HMGB1 secretion can reverse these changes, suggesting that HMGB1 may be a potential target for the treatment of brain diseases.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Medicine, Research & Experimental
Wei-tong Pan, Pan-miao Liu, Daqing Ma, Jian-jun Yang
Summary: Cognitive function is a crucial ability of the brain, but it can be impaired in various neurological conditions or diseases. Photobiomodulation therapy, a noninvasive physical therapy, has emerged in the field of neuroscience. Transcranial photobiomodulation is commonly used to regulate neural activity in the superficial cortex, while advanced techniques involving photosensitive nanoparticles have been developed to stimulate deeper brain activity. This review examines the mechanisms, advantages, disadvantages, and potential applications of photobiomodulation and its combination with photosensitive nanoparticles on neurons and neural networks. These strategies may offer promising treatments for cognitive improvement.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Neurosciences
Yu-zhu Gao, Xin-miao Wu, Zhi-qiang Zhou, Pan-miao Liu, Jian-jun Yang, Mu-huo Ji
Summary: Accumulating evidence suggests that many sepsis survivors experience long-term cognitive impairments after hospital discharge, causing reduced quality of life and burden for their families. This study utilized a mouse model and various techniques to investigate the role of NRG1/ErbB4 signaling, PV interneurons, and hippocampal neural oscillations in memory decline after repeated LPS injections. The results demonstrated that dysfunction of NRG1/ErbB4 signaling in the hippocampus may contribute to the long-term memory decline observed in the systemic inflammation mouse model. Targeting NRG1/ErbB4 signaling in the hippocampus could be a promising approach for preventing and treating this memory decline.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Ting-ting Zhu, He Wang, Han-wen Gu, Ling-sha Ju, Xin-miao Wu, Wei-tong Pan, Ming-ming Zhao, Jian-jun Yang, Pan-miao Liu
Summary: Inflammatory depression is closely related to neuroinflammation. Melanin-like polydopamine nanoparticles (PDA NPs) were synthesized using nano-based drug delivery technology to overcome the low permeability of current anti-inflammatory drugs. PDA NPs, with abundant phenolic hydroxyl groups, showed excellent antioxidative properties and were effective in treating lipopolysaccharide-induced inflammatory depression in mice. PDA NPs reduced inflammation, restored synaptic loss, and exhibited good biocompatibility.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Anesthesiology
Wen Duan, Cheng-Mao Zhou, Jin-Jin Yang, Yue Zhang, Ze-Ping Li, Da-Qing Ma, Jian-Jun Yang
Summary: This study investigated the association between the duration of intraoperative hypotension and the incidence of postoperative delirium (POD) in elderly patients undergoing thoracic and orthopedic surgery. The results showed that a duration of hypotension of 5 minutes or longer was closely related to an increased incidence of POD.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
