Impact of RNA–Protein Interaction Modes on Translation Control: The Versatile Multidomain Protein Gemin5

The role of survival motor neuron protein (SMN) in protein homeostasis

(2018) Helena Chaytow et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Expanding horizons: new roles for non-canonical RNA-binding proteins in cancer

(2018) Samantha Moore et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Unconventional RNA-binding proteins: an uncharted zone in RNA biology

(2018) Waleed S. Albihlal et al.   FEBS LETTERS

Sequence, Structure, and Context Preferences of Human RNA Binding Proteins

(2018) Daniel Dominguez et al.   MOLECULAR CELL

HuD Is a Neural Translation Enhancer Acting on mTORC1-Responsive Genes and Counteracted by the Y3 Small Non-coding RNA

(2018) Toma Tebaldi et al.   MOLECULAR CELL

A brave new world of RNA-binding proteins

(2018) Matthias W. Hentze et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human La binds mRNAs through contacts to the poly(A) tail

(2018) Jyotsna Vinayak et al.   NUCLEIC ACIDS RESEARCH

A translational silencing function of MCPIP1/Regnase-1 specified by the target site context

(2018) Gesine Behrens et al.   NUCLEIC ACIDS RESEARCH

The landscape of the non-canonical RNA-binding site of Gemin5 unveils a feedback loop counteracting the negative effect on translation

(2018) Rosario Francisco-Velilla et al.   NUCLEIC ACIDS RESEARCH

CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts

(2018) Ricardos Tabet et al.   Nature Communications

A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets

(2018) Fruzsina Hobor et al.   Nature Communications

Ribosome-dependent conformational flexibility changes and RNA dynamics of IRES domains revealed by differential SHAPE

(2018) Gloria Lozano et al.   Scientific Reports

The Coding Regions of Germline mRNAs Confer Sensitivity to Argonaute Regulation in C. elegans

(2018) Meetu Seth et al.   Cell Reports

Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virus

(2018) Miguel Rodríguez Pulido et al.   PLoS Pathogens

START: STructure-Assisted RNA Translation

(2018) Gilbert Eriani et al.   RNA Biology

Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation

(2018) Katharina Essig et al.   Nature Communications

The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest

(2018) Jakob Trendel et al.   CELL

Identification of new high affinity targets for Roquin based on structural conservation

(2018) Johannes Braun et al.   NUCLEIC ACIDS RESEARCH

G3BP1 interacts directly with the FMDV IRES and negatively regulates translation

(2017) Alfonso Galan et al.   FEBS Journal

Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions

(2017) Miguel Mompeán et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis

(2017) Thomas Treiber et al.   MOLECULAR CELL

Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them

(2017) Kathrin Leppek et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Does eIF3 promote reinitiation after translation of short upstream ORFs also in mammalian cells?

(2017) Vladislava Hronová et al.   RNA Biology

Deciphering the mRNP Code: RNA-Bound Determinants of Post-Transcriptional Gene Regulation

(2017) Niels H. Gehring et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural Insights into the Mechanism of Scanning and Start Codon Recognition in Eukaryotic Translation Initiation

(2017) Alan G. Hinnebusch   TRENDS IN BIOCHEMICAL SCIENCES

The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly

(2017) Paul G. Donlin-Asp et al.   Cell Reports

In Vivo Translatome Profiling in Spinal Muscular Atrophy Reveals a Role for SMN Protein in Ribosome Biology

(2017) Paola Bernabò et al.   Cell Reports

Determinants of affinity and specificity in RNA-binding proteins

(2016) Stephanie Helder et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5

(2016) Wenxing Jin et al.   GENES & DEVELOPMENT

Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly

(2016) Chao Xu et al.   GENES & DEVELOPMENT

Comprehensive Identification of RNA-Binding Domains in Human Cells

(2016) Alfredo Castello et al.   MOLECULAR CELL

CGG Repeat-Associated Non-AUG Translation Utilizes a Cap-Dependent Scanning Mechanism of Initiation to Produce Toxic Proteins

(2016) Michael G. Kearse et al.   MOLECULAR CELL

Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)

(2016) Eric L Van Nostrand et al.   NATURE METHODS

Human eIF3b and eIF3a serve as the nucleation core for the assembly of eIF3 into two interconnected modules: the yeast-like core and the octamer

(2016) Susan Wagner et al.   NUCLEIC ACIDS RESEARCH

The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translation

(2016) Rosario Francisco-Velilla et al.   NUCLEIC ACIDS RESEARCH

Translational control by 5'-untranslated regions of eukaryotic mRNAs

(2016) A. G. Hinnebusch et al.   SCIENCE

The role of eIF3 and its individual subunits in cancer

(2015) John W.B. Hershey   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

(2015) Takashi Mino et al.   CELL

Gemin5 Binds to the Survival Motor Neuron mRNA to Regulate SMN Expression

(2015) Eileen Workman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinated Ribosomal L4 Protein Assembly into the Pre-Ribosome Is Regulated by Its Eukaryote-Specific Extension

(2015) Philipp Stelter et al.   MOLECULAR CELL

eIF3 targets cell-proliferation messenger RNAs for translational activation or repression

(2015) Amy S. Y. Lee et al.   NATURE

hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1

(2015) Yoichiro Sugimoto et al.   NATURE

Structural imprints in vivo decode RNA regulatory mechanisms

(2015) Robert C. Spitale et al.   NATURE

Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP

(2015) Nikita Vasilyev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs

(2015) Benedikt M. Beckmann et al.   Nature Communications

Structural insights into viral IRES-dependent translation mechanisms

(2015) Gloria Lozano et al.   Current Opinion in Virology

The Carboxy-Terminal Domain of Erb1 Is a Seven-Bladed ß-Propeller that Binds RNA

(2015) Wegrecki Marcin et al.   PLoS One

A census of human RNA-binding proteins

(2014) Stefanie Gerstberger et al.   NATURE REVIEWS GENETICS

The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA

(2014) Dazhi Tan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of novel non-canonical RNA-binding sites in Gemin5 involved in internal initiation of translation

(2014) Javier Fernandez-Chamorro et al.   NUCLEIC ACIDS RESEARCH

PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity

(2014) Je-Hyun Yoon et al.   Nature Communications

The RNAissance family: SR proteins as multifaceted regulators of gene expression

(2014) Jonathan M. Howard et al.   Wiley Interdisciplinary Reviews-RNA

The role of disordered protein regions in the assembly of decapping complexes and RNP granules

(2013) S. Jonas et al.   GENES & DEVELOPMENT

Human Eukaryotic Initiation Factor 4G (eIF4G) Protein Binds to eIF3c, -d, and -e to Promote mRNA Recruitment to the Ribosome

(2013) Nancy Villa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit

(2013) Yaser Hashem et al.   NATURE

Staufen1 senses overall transcript secondary structure to regulate translation

(2013) Emiliano P Ricci et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The DEAD-box helicase DDX3 substitutes for the cap-binding protein eIF4E to promote compartmentalized translation initiation of the HIV-1 genomic RNA

(2013) Ricardo Soto-Rifo et al.   NUCLEIC ACIDS RESEARCH

Structural features of Argonaute-GW182 protein interactions

(2013) J. Pfaff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel insight into the mechanism of mammalian selenoprotein synthesis

(2013) O. Kossinova et al.   RNA

Structural and functional analysis of the U3 snoRNA binding protein Rrp9

(2013) L. Zhang et al.   RNA

SMN Is Essential for the Biogenesis of U7 Small Nuclear Ribonucleoprotein and 3′-End Formation of Histone mRNAs

(2013) Sarah Tisdale et al.   Cell Reports

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

A novel function for the survival motoneuron protein as a translational regulator

(2012) Gabriel Sanchez et al.   HUMAN MOLECULAR GENETICS

Combinatorial Mutagenesis of MBNL1 Zinc Fingers Elucidates Distinct Classes of Regulatory Events

(2012) J. Purcell et al.   MOLECULAR AND CELLULAR BIOLOGY

mRNA Decay Factor AUF1 Maintains Normal Aging, Telomere Maintenance, and Suppression of Senescence by Activation of Telomerase Transcription

(2012) Adam R. Pont et al.   MOLECULAR CELL

The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts

(2012) Alexander G. Baltz et al.   MOLECULAR CELL

Gemin5 proteolysis reveals a novel motif to identify L protease targets

(2012) David Piñeiro et al.   NUCLEIC ACIDS RESEARCH

Gemin5 promotes IRES interaction and translation control through its C-terminal region

(2012) David Piñeiro et al.   NUCLEIC ACIDS RESEARCH

Implication of the SMN complex in the biogenesis and steady state level of the Signal Recognition Particle

(2012) N. Piazzon et al.   NUCLEIC ACIDS RESEARCH

The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution

(2012) Esmé Waanders et al.   PLoS Genetics

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Rhythmic Interaction between Period1 mRNA and hnRNP Q Leads to Circadian Time-Dependent Translation

(2011) K.-H. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

The STAR RNA binding proteins GLD-1, QKI, SAM68 and SLM-2 bind bipartite RNA motifs

(2009) André Galarneau et al.   BMC MOLECULAR BIOLOGY

Gemin5-snRNA interaction reveals an RNA binding function for WD repeat domains

(2009) Chi-kong Lau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of Gemin5 as a Novel 7-Methylguanosine Cap-Binding Protein

(2009) Shelton S. Bradrick et al.   PLoS One

A novel role for Gemin5 in mRNA translation

(2008) Almudena Pacheco et al.   NUCLEIC ACIDS RESEARCH

Riboproteomic analysis of polypeptides interacting with the internal ribosome-entry site element of foot-and-mouth disease viral RNA

(2008) Almudena Pacheco et al.   PROTEOMICS