Review
Biochemistry & Molecular Biology
Mohammad Zaki Bin Ibrahim, Amrita Benoy, Sreedharan Sajikumar
Summary: Synaptic plasticity refers to the malleability of biochemical structures between neurons, affecting learning and memory. Different forms of synaptic plasticity, such as LTP and LTD, play specific cognitive roles in reinforcement, relearning, and memory association. Apart from homosynaptic modifications, synapses can interact with each other, as described by the synaptic tagging and capture hypothesis (STC).
Review
Biochemistry & Molecular Biology
Gavin R. Hoffman, Madeline G. Olson, Allen M. Schoffstall, Ryan F. Estevez, Vincent Van den Eynde, Peter K. Gillman, Maureen E. Stabio
Summary: The discovery of monoamine oxidase inhibitors (MAOIs) in the 1950s revolutionized the field of medicine by creating a new class of powerful antidepressant drugs. However, their use has declined over time due to side effects and the introduction of other antidepressant drug classes. Recent research has sparked renewed interest in the use of MAOIs in treating depression.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Clinical Neurology
Flavia Rossano, Claudio Caiazza, Andrea Sobrino, Niccolo Solini, Alessandro Vellucci, Nicolas Zotti, Michele Fornaro, Ken Gillman, Carlo Ignazio Cattaneoc, Vincent Van den Eynde, Tom K. Birkenhagerf, Henricus G. Ruhe, Stephen Stahl, Felice Iasevoli, Andrea de Bartolomeisa
Summary: A systematic review and meta-analysis evaluated the evidence of different formulations/dosages of selegiline across different psychiatric conditions. Selegiline outperformed placebo in reducing depressive symptoms, depression, and atypical depression response, but showed no significant difference in other psychiatric disorders. The confidence in most outcomes was low, except for depressive symptoms reduction.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wonseok Chang, Jihua An, Geun Hee Seol, Seung Ho Han, Jaeyong Yee, Sun Seek Min
Summary: Trans-anethole has neuroprotective effects and can positively influence synaptic plasticity, which suggests its potential for improving cognitive impairment caused by neurodegenerative diseases.
Article
Multidisciplinary Sciences
Kif Liakath-Ali, Jai S. Polepalli, Sung-Jin Lee, Jean-Francois Cloutier, Thomas C. Sudhof
Summary: This study reveals the crucial role of presynaptic neurexin-ligand cerebellin-4 (Cbln4) in long-term potentiation (LTP) at EC -> DG synapses. Binding of presynaptic Cbln4 to postsynaptic neogenin-1 enables the EC -> DG synapses to undergo LTP, but is not necessary for the establishment or function of these synapses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Sahifeh Kazemi, Samaneh Safari, Somayeh Komaki, Seyed Asaad Karimi, Zoleikha Golipoor, Alireza Komaki
Summary: This study assessed the effects of carvacrol (CAR) and p-cymene on hippocampal long-term potentiation (LTP) in a rat model of Alzheimer's disease (AD). The results showed that CAR and p-cymene can ameliorate synaptic plasticity changes associated with AD, but their combination did not have the same effect.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Immunology
Zhen Tian, Xinyue Wang, Tianshu Han, Changhao Sun
Summary: This study demonstrates that the selective MAO-B inhibitor, selegiline, can reduce body weight gain, hepatic steatosis, and dyslipidemia induced by a high-fat diet. These protective effects may be attributed to improved inflammatory response, oxidative stress, and hepatic lipid metabolism.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Neurosciences
Sergio Valbuena, Juan Lerma
Summary: Synaptic plasticity, characterized as key processes allowing the brain to operate dynamically, involves various modulators including kainate receptors, which play an important role in regulating neurotransmitter release and bidirectionally modulating plasticity.
Review
Neurosciences
Sa Weon Hong, Paul Teesdale-Spittle, Rachel Page, Penelope Truman
Summary: Nicotine addiction is not solely due to nicotine itself, but also related to MAO inhibition caused by non-nicotinic components in tobacco smoke. This review identifies potential pharmacological candidates as MAO inhibitors from tobacco and tobacco smoke. It contributes to our understanding of the impact of smoking on MAO activity and nicotine addiction.
Article
Neurosciences
Randa Kassab
Summary: This article introduces a new method for modeling the CA3 network, focusing on the impact of long-term potentiation (LTP) on CA3 functional connectivity. The study found that only a small fraction of active synapses should be connected to activated cells to achieve optimal performance. This control of connectivity is achieved by acetylcholine modulating the trafficking and adjustment of the AMPA receptors.
Article
Psychiatry
Thomas T. Kim, Jay D. Amsterdam
Summary: This study compared the safety and effectiveness of MAOI therapy in patients with bipolar depression versus unipolar depression. The results showed that patients with bipolar depression had lower post-treatment clinical global impressions/severity scores compared to patients with unipolar depression.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Neurosciences
William Almaguer-Melian, Daymara Merceron-Martinez, Jorge Bergado-Rosado
Summary: Synaptic plasticity plays a crucial role in memory encoding and storage. The administration of erythropoietin (EPO) has been shown to restore synaptic function and improve learning and memory ability. In a study using the fimbria-fornix lesion model, it was found that EPO can recover the capacity of synapses to produce long-lasting increases in transmission efficiency.
Article
Biochemistry & Molecular Biology
Douglas A. Formolo, Thomas H. Lee, Jiasui Yu, Kangguang Lin, Gang Chen, Georg S. Kranz, Suk-Yu Yau
Summary: Sub-chronic treatment with AdipoRon has antidepressant- and anxiolytic-like effects in mice, independent of changes in hippocampal neurogenesis and synaptic plasticity.
Article
Neurosciences
Thomas E. Chater, Yukiko Goda
Summary: Synaptic strength changes based on activity, with inactive neighbouring synapses also potentially changing. These heterosynaptic changes occur in various brain circuits across species, but their molecular mechanisms remain unclear. They can mirror or oppose homosynaptic plasticity, providing useful functionality to the circuit. Unanswered questions remain, but the future of understanding synaptic plasticity looks promising.
CURRENT OPINION IN NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Tetsuya Nishimura, Kazue Takahata, Yuri Kosugi, Takaaki Tanabe, Shizuko Muraoka
JOURNAL OF NEURAL TRANSMISSION
(2017)
Article
Behavioral Sciences
Hiroko Tsunekawa, Kazue Takahata, Motoki Okano, Toshiko Ishikawa, Hiroshi Satoyoshi, Tetsuya Nishimura, Naoya Hoshino, Shizuko Muraoka
BEHAVIOURAL BRAIN RESEARCH
(2018)
Article
Neurosciences
Takeshi Amino, Toshiki Uchihara, Hiroko Tsunekawa, Kazue Takahata, Seiichiro Shimazu, Hidehiro Nlizusawa, Satoshi Orimo
NEUROSCIENCE RESEARCH
(2008)
Article
Behavioral Sciences
Motoki Okano, Kazue Takahata, Junya Sugimoto, Shizuko Muraoka
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2019)
Article
Pharmacology & Pharmacy
Junya Sugimoto, Hiroshi Satoyoshi, Kazue Takahata, Shizuko Muraoka
Summary: Fabry disease is an X-linked metabolic storage disorder caused by lysosomal alpha-galactosidase A deficiency. Research suggests that the nerve growth factor signaling pathway may be a potential cause of Fabry disease-associated pain.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Yoshitsugu Nakamura, Shigeki Arawaka, Hiroyasu Sato, Asuka Sasaki, Taro Shigekiyo, Kazue Takahata, Hiroko Tsunekawa, Takeo Kato
Summary: Inhibiting MAO-B enzymatic activity can facilitate the secretion of alpha-synuclein and delay protein aggregation and loss of dopaminergic neurons in Parkinson's disease models.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
K Takahata, S Shimazu, H Katsuki, F Yoneda, A Akaike
JOURNAL OF NEURAL TRANSMISSION
(2006)
Article
Pharmacology & Pharmacy
K Takahata, A Minami, H Kusumoto, S Shimazu, F Yoneda
EUROPEAN JOURNAL OF PHARMACOLOGY
(2005)
Article
Pharmacology & Pharmacy
C Hirami, K Takahata, S Shimazu, F Yoneda, K Hayashi, H Katsuki, A Akaike
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2005)
Article
Pharmacology & Pharmacy
K Takahata, S Shimazu, F Yoneda
PHARMACOLOGICAL RESEARCH
(2004)
Article
Clinical Neurology
K Takahata, S Shimazu, F Yoneda, M Ogawa, Y Iida, H Saji
JOURNAL OF NEURAL TRANSMISSION
(2003)
Article
Pharmacology & Pharmacy
K Takahata, H Katsuki, T Kume, K Ito, Y Tochikawa, S Muraoka, F Yoneda, S Kashii, Y Honda, A Akaike
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2003)
Article
Clinical Neurology
S Shimazu, K Takahata, A Tamashiro, F Yoneda, Y Iida, H Saji
JOURNAL OF NEURAL TRANSMISSION
(2003)
Article
Ophthalmology
K Takahata, H Katsuki, T Kume, D Nakata, K Ito, S Muraoka, F Yoneda, S Kashii, Y Honda, A Akaike
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2003)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)