Therapeutic Benefits of Spleen Tyrosine Kinase Inhibitor Administration on Binge Drinking-Induced Alcoholic Liver Injury, Steatosis, and Inflammation in Mice

Versican: a novel modulator of hepatic fibrosis

(2016) Terence N Bukong et al.   LABORATORY INVESTIGATION

Gut–Liver Axis in Alcoholic Liver Disease

(2015) Gyongyi Szabo   GASTROENTEROLOGY

Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat–cholesterol–sugar diet model in mice

(2015) Michal Ganz et al.   Journal of Translational Medicine

Correlation of disease activity in proliferative glomerulonephritis with glomerular spleen tyrosine kinase expression

(2015) Stephen P. McAdoo et al.   KIDNEY INTERNATIONAL

Alcoholic liver disease: mechanisms of injury and targeted treatment

(2015) Alexandre Louvet et al.   Nature Reviews Gastroenterology & Hepatology

SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia

(2014) Alexandre Puissant et al.   CANCER CELL

Expression of Variant Isoforms of the Tyrosine Kinase SYK Determines the Prognosis of Hepatocellular Carcinoma

(2014) Jian Hong et al.   CANCER RESEARCH

Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses

(2014) Young-Su Yi et al.   MEDIATORS OF INFLAMMATION

Acute Binge Drinking Increases Serum Endotoxin and Bacterial DNA Levels in Healthy Individuals

(2014) Shashi Bala et al.   PLoS One

Binge Ethanol and Liver: New Molecular Developments

(2013) Shivendra D. Shukla et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

(2013) J. Petrasek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: implications for SYK inhibitors in autoimmune disease therapy

(2013) Cheng Liao et al.   ARTHRITIS RESEARCH & THERAPY

Rodent models of alcoholic liver disease: Of mice and men

(2012) Elizabeth Brandon-Warner et al.   ALCOHOL

Inhibition of Syk activity by R788 in platelets prevents remote lung tissue damage after mesenteric ischemia-reperfusion injury

(2012) Peter H. Lapchak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pharmacokinetics of fostamatinib, a spleen tyrosine kinase (SYK) inhibitor, in healthy human subjects following single and multiple oral dosing in three phase I studies

(2012) Muhammad Baluom et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The SYK side of TLR4: signalling mechanisms in response to LPS and minimally oxidized LDL

(2012) Yury I Miller et al.   BRITISH JOURNAL OF PHARMACOLOGY

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

(2012) Jan Petrasek et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of Bcl-3 by acute binge alcohol results in Toll-like receptor 4/LPS tolerance

(2012) S. Bala et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Elevated Activation of ERK1 and ERK2 Accompany Enhanced Liver Injury Following Alcohol Binge in Chronically Ethanol-Fed Rats

(2011) Annayya R. Aroor et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Critical role for Syk in responses to vascular injury

(2011) P. Andre et al.   BLOOD

Role of Spleen Tyrosine Kinase Inhibitors in the Management of Rheumatoid Arthritis

(2011) David L. Scott   DRUGS

An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: A three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents

(2010) Mark C. Genovese et al.   ARTHRITIS AND RHEUMATISM

Mechanisms and cell signaling in alcoholic liver disease

(2010) Juliane I. Beier et al.   BIOLOGICAL CHEMISTRY

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-inflammatory actions of Syk inhibitors in macrophages involve non-specific inhibition of toll-like receptors-mediated JNK signaling pathway

(2010) Ying-Cing Lin et al.   MOLECULAR IMMUNOLOGY

Alcoholic liver disease and the gut-liver axis

(2010) Gyongyi Szabo   WORLD JOURNAL OF GASTROENTEROLOGY

Drinking patterns, dependency and life-time drinking history in alcohol-related liver disease

(2009) Jennifer Hatton et al.   ADDICTION

Binge drinking in young adults: Data, definitions, and determinants.

(2009) Kelly E. Courtney et al.   PSYCHOLOGICAL BULLETIN

Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors

(2008) Kevin M. Dennehy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY