Mechanisms of Activation of Receptor Tyrosine Kinases: Monomers or Dimers

Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor

(2013) Nicholas F. Endres et al.   CELL

An Intracellular Domain Fragment of the p75 Neurotrophin Receptor (p75NTR) Enhances Tropomyosin Receptor Kinase A (TrkA) Receptor Function

(2013) Dusan Matusica et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Analysis of the Epidermal Growth Factor (EGF) Receptor-ErbB2-ErbB3 Protein Network by Luciferase Fragment Complementation Imaging

(2013) Jennifer L. Macdonald-Obermann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand signature in the membrane dynamics of single TrkA receptor molecules

(2013) L. Marchetti et al.   JOURNAL OF CELL SCIENCE

How insulin engages its primary binding site on the insulin receptor

(2013) John G. Menting et al.   NATURE

The Insulin Receptor: Both a Prototypical and Atypical Receptor Tyrosine Kinase

(2013) S. R. Hubbard   Cold Spring Harbor Perspectives in Biology

Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family

(2012) Stephen C. Artim et al.   BIOCHEMICAL JOURNAL

Mechanisms for Kinase-mediated Dimerization of the Epidermal Growth Factor Receptor

(2012) Chafen Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Crystal Structures of TrkA and TrkB Suggest Key Regions for Achieving Selective Inhibition

(2012) T. Bertrand et al.   JOURNAL OF MOLECULAR BIOLOGY

A single ligand is sufficient to activate EGFR dimers

(2012) P. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional isolation of activated and unilaterally phosphorylated heterodimers of ERBB2 and ERBB3 as scaffolds in ligand-dependent signaling

(2012) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms

(2011) Louise Knudsen et al.   BIOCHEMICAL JOURNAL

Insulin Receptor-Related Receptor as an Extracellular Alkali Sensor

(2011) Igor E. Deyev et al.   Cell Metabolism

The Membrane-proximal Intracellular Domain of the Epidermal Growth Factor Receptor Underlies Negative Cooperativity in Ligand Binding

(2011) Sangeeta Adak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Model for p75NTR–TrkA Intracellular Domain Interaction: A Combined FRET and Bioinformatics Study

(2011) María Florencia Iacaruso et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanics of EGF Receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging

(2011) J. L. Macdonald-Obermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor

(2010) Diego Alvarado et al.   CELL

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Nerve growth factor receptor TrkA exists as a preformed, yet inactive, dimer in living cells

(2010) Jianying Shen et al.   FEBS LETTERS

The Tethering Arm of the EGF Receptor Is Required for Negative Cooperativity and Signal Transduction

(2010) Sangeeta Adak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

(2010) Fumin Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distribution of resting and ligand-bound ErbB1 and ErbB2 receptor tyrosine kinases in living cells using number and brightness analysis

(2010) P. Nagy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The proliferating role of insulin and insulin-like growth factors in cancer

(2010) Emily Jane Gallagher et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Homo-FRET Imaging Enables Quantification of Protein Cluster Sizes with Subcellular Resolution

(2009) Arjen N. Bader et al.   BIOPHYSICAL JOURNAL

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment

(2009) Natalia Jura et al.   CELL

Trk Receptor Expression and Inhibition in Neuroblastomas

(2009) G. M. Brodeur et al.   CLINICAL CANCER RESEARCH

ErbB receptors and signaling pathways in cancer

(2009) Nancy E Hynes et al.   CURRENT OPINION IN CELL BIOLOGY

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Luciferase Fragment Complementation Imaging of Conformational Changes in the Epidermal Growth Factor Receptor

(2009) Katherine S. Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Intracellular Juxtamembrane Domain of the Epidermal Growth Factor (EGF) Receptor Is Responsible for the Allosteric Regulation of EGF Binding

(2009) Jennifer L. Macdonald-Obermann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor

(2009) M. Vilar et al.   JOURNAL OF CELL SCIENCE

The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain

(2009) Monica Red Brewer et al.   MOLECULAR CELL

Harmonic oscillator model of the insulin and IGF1 receptors’ allosteric binding and activation

(2009) Vladislav V Kiselyov et al.   Molecular Systems Biology

Activation of the p75 Neurotrophin Receptor through Conformational Rearrangement of Disulphide-Linked Receptor Dimers

(2009) Marçal Vilar et al.   NEURON

Mechanisms, locations, and kinetics of synaptic BDNF secretion: An update

(2009) Volkmar Leßmann et al.   NEUROSCIENCE RESEARCH

Structure-Based View of Epidermal Growth Factor Receptor Regulation

(2008) Kathryn M. Ferguson   Annual Review of Biophysics

Acromegaly, growth hormone and cancer risk

(2008) Andrew G. Renehan et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Insulin action on glucose transporters through molecular switches, tracks and tethers

(2008) Hilal Zaid et al.   BIOCHEMICAL JOURNAL

Ligand-induced ErbB receptor dimerization

(2008) Mark A. Lemmon   EXPERIMENTAL CELL RESEARCH

All EGF(ErbB) receptors have preformed homo- and heterodimeric structures in living cells

(2008) R.-H. Tao et al.   JOURNAL OF CELL SCIENCE

Functional selectivity of EGF family peptide growth factors: Implications for cancer

(2008) Kristy J. Wilson et al.   PHARMACOLOGY & THERAPEUTICS

The insulin receptor: a prototype for dimeric, allosteric membrane receptors?

(2008) Pierre De Meyts   TRENDS IN BIOCHEMICAL SCIENCES