Development of Severe Combined Immunodeficient (SCID) Pig Models for Translational Cancer Modeling: Future Insights on How Humanized SCID Pigs Can Improve Preclinical Cancer Research

Production and rearing of germ-free X-SCID pigs

(2018) Hiromasa Hara et al.   EXPERIMENTAL ANIMALS

Creating effective biocontainment facilities and maintenance protocols for raising specific pathogen-free, severe combined immunodeficient (SCID) pigs

(2018) Ellis J Powell et al.   LABORATORY ANIMALS

Chimeric Antigen Receptor Expressing Natural Killer Cells for the Immunotherapy of Cancer

(2018) Rohtesh S. Mehta et al.   Frontiers in Immunology

Porcine signal regulatory protein alpha binds to human CD47 to inhibit phagocytosis: Implications for human hematopoietic stem cell transplantation into severe combined immunodeficient pigs

(2018) Adeline N. Boettcher et al.   XENOTRANSPLANTATION

Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity

(2017) E Liu et al.   LEUKEMIA

An in-depth comparison of the porcine, murine and human inflammasomes; lessons from the porcine genome and transcriptome

(2017) Harry D. Dawson et al.   VETERINARY MICROBIOLOGY

Recombination activating gene-2null severe combined immunodeficient pigs and mice engraft human induced pluripotent stem cells differently

(2017) Yun-Jung Choi et al.   Oncotarget

Lung Cancer-Targeting Peptides with Multi-subtype Indication for Combinational Drug Delivery and Molecular Imaging

(2017) Yi-Hsuan Chi et al.   Theranostics

T Cell Lymphoma and Leukemia in Severe Combined Immunodeficiency Pigs following Bone Marrow Transplantation: A Case Report

(2017) Ellis J. Powell et al.   Frontiers in Immunology

Non-invasive quantitative imaging of hepatocellular carcinoma growth in mice by micro-CT using liver-targeted iodinated nano-emulsions

(2017) Nicolas Anton et al.   Scientific Reports

Autologous T Cells Expressing CD30 Chimeric Antigen Receptors for Relapsed or Refractory Hodgkin Lymphoma: An Open-Label Phase I Trial

(2016) Chun-Meng Wang et al.   CLINICAL CANCER RESEARCH

Innovation in the pharmaceutical industry: New estimates of R&D costs

(2016) Joseph A. DiMasi et al.   JOURNAL OF HEALTH ECONOMICS

Biallelic modification of IL2RG leads to severe combined immunodeficiency in pigs

(2016) Jung-Taek Kang et al.   Reproductive Biology and Endocrinology

Propagating Humanized BLT Mice for the Study of Human Immunology and Immunotherapy

(2016) Drake J. Smith et al.   STEM CELLS AND DEVELOPMENT

Generation and characterization of RAG2 knockout pigs as animal model for severe combined immunodeficiency

(2016) Shunichi Suzuki et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

NK cells are intrinsically functional in pigs with Severe Combined Immunodeficiency (SCID) caused by spontaneous mutations in the Artemis gene

(2016) Ellis J. Powell et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Increased and prolonged human norovirus infection in RAG2/IL2RG deficient gnotobiotic pigs with severe combined immunodeficiency

(2016) Shaohua Lei et al.   Scientific Reports

Toxicity and management in CAR T-cell therapy

(2016) Challice L Bonifant et al.   Molecular Therapy-Oncolytics

Optimization of Intrabone Delivery of Hematopoietic Progenitor Cells in a Swine Model Using Cell Radiolabeling with [89]zirconium

(2015) J. M. Pantin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia

(2015) S. L. Maude et al.   BLOOD

Adult porcine genome-wide DNA methylation patterns support pigs as a biomedical model

(2015) Kyle M. Schachtschneider et al.   BMC GENOMICS

Preclinical Mouse Cancer Models: A Maze of Opportunities and Challenges

(2015) Chi-Ping Day et al.   CELL

Human CD34loCD133lo fetal liver cells support the expansion of human CD34hiCD133hi hematopoietic stem cells

(2015) Kylie Su Mei Yong et al.   Cellular & Molecular Immunology

NK-92 cells engineered with anti-CD33 chimeric antigen receptors (CAR) for the treatment of Acute Myeloid Leukemia (AML)

(2015) Sarwish Rafiq et al.   CYTOTHERAPY

Livestock Models in Translational Medicine

(2015) J. A. Roth et al.   ILAR JOURNAL

Clostridium perfringensenterotoxin C-terminal domain labeled to fluorescent dyes forin vivovisualization of micrometastatic chemotherapy-resistant ovarian cancer

(2015) Emiliano Cocco et al.   INTERNATIONAL JOURNAL OF CANCER

Not All SCID Pigs Are Created Equally: Two Independent Mutations in theArtemisGene Cause SCID in Pigs

(2015) Emily H. Waide et al.   JOURNAL OF IMMUNOLOGY

Treatment of CD33-directed Chimeric Antigen Receptor-modified T Cells in One Patient With Relapsed and Refractory Acute Myeloid Leukemia

(2015) Quan-shun Wang et al.   MOLECULAR THERAPY

A multifunctional peptide for targeted imaging and chemotherapy for nasopharyngeal and breast cancers

(2015) Jong-Kai Hsiao et al.   Nanomedicine-Nanotechnology Biology and Medicine

A Genetic Porcine Model of Cancer

(2015) Lawrence B. Schook et al.   PLoS One

Viable pigs with a conditionally-activated oncogenic KRAS mutation

(2015) Shun Li et al.   TRANSGENIC RESEARCH

Development of a simple procedure for the treatment of femoral head osteonecrosis with intra-osseous injection of bone marrow mesenchymal stromal cells: study of their biodistribution in the early time points after injection

(2015) Angélique Lebouvier et al.   Stem Cell Research & Therapy

Comparison of minipig, dog, monkey and human drug metabolism and disposition

(2015) Lars Dalgaard   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Hematopoiesis in the equine fetal liver suggests immune preparedness

(2014) J. M. Battista et al.   IMMUNOGENETICS

Signal-regulatory proteinαfrom the NOD mouse binds human CD47 with an exceptionally high affinity - implications for engraftment of human cells

(2014) Lai Shan Kwong et al.   IMMUNOLOGY

Development and translational imaging of a TP53 porcine tumorigenesis model

(2014) Jessica C. Sieren et al.   JOURNAL OF CLINICAL INVESTIGATION

Xenograft Tolerance and Immune Function of Human T Cells Developing in Pig Thymus Xenografts

(2014) H. Kalscheuer et al.   JOURNAL OF IMMUNOLOGY

RAG1/2 Knockout Pigs with Severe Combined Immunodeficiency

(2014) J. Huang et al.   JOURNAL OF IMMUNOLOGY

Generation of Recombination Activating Gene-1-Deficient Neonatal Piglets: A Model of T and B Cell Deficient Severe Combined Immune Deficiency

(2014) Tetsuya Ito et al.   PLoS One

Engraftment of human iPS cells and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency

(2014) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment

(2013) T. Yamauchi et al.   BLOOD

Structural and functional annotation of the porcine immunome

(2013) Harry D Dawson et al.   BMC GENOMICS

The impact of breed and tissue compartment on the response of pig macrophages to lipopolysaccharide

(2013) Ronan Kapetanovic et al.   BMC GENOMICS

Generation of CD34+ cells from human embryonic stem cells using a clinically applicable methodology and engraftment in the fetal sheep model

(2013) Jaehyup Kim et al.   EXPERIMENTAL HEMATOLOGY

NOD-scid IL2R γnull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways

(2013) Maryam Zadeh-Khorasani et al.   Journal of Translational Medicine

Generation of Interleukin-2 Receptor Gamma Gene Knockout Pigs from Somatic Cells Genetically Modified by Zinc Finger Nuclease-Encoding mRNA

(2013) Masahito Watanabe et al.   PLoS One

Mesenchymal Stem Cells Systemically Injected into Femoral Marrow of Dogs Home to Mandibular Defects to Enhance New Bone Formation

(2013) Xian Liu et al.   TISSUE ENGINEERING PART A

In utero transplantation: Disparate ramifications

(2013) John S Pixley   World Journal of Stem Cells

Il2rg Gene-Targeted Severe Combined Immunodeficiency Pigs

(2012) Shunichi Suzuki et al.   Cell Stem Cell

Graft versus Host Disease in the Bone Marrow, Liver and Thymus Humanized Mouse Model

(2012) Matthew B. Greenblatt et al.   PLoS One

Inactivation and Inducible Oncogenic Mutation of p53 in Gene Targeted Pigs

(2012) Simon Leuchs et al.   PLoS One

Preliminary Findings of a Previously Unrecognized Porcine Primary Immunodeficiency Disorder

(2012) A. G. Cino Ozuna et al.   VETERINARY PATHOLOGY

Mouse models of graft-versus-host disease: advances and limitations

(2011) M. A. Schroeder et al.   Disease Models & Mechanisms

High drug attrition rates—where are we going wrong?

(2011) Lisa Hutchinson et al.   Nature Reviews Clinical Oncology

In uterocell transfer between porcine littermates

(2011) Andrea McConico et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Swine as Models in Biomedical Research and Toxicology Testing

(2011) M. M. Swindle et al.   VETERINARY PATHOLOGY

Humanized mouse models to study human diseases

(2011) Michael A Brehm et al.   Current Opinion in Endocrinology Diabetes and Obesity

Clostridium perfringens enterotoxin carboxy-terminal fragment is a novel tumor-homing peptide for human ovarian cancer

(2010) Emiliano Cocco et al.   BMC CANCER

Human T cells in hu-PBL-SCID mice proliferate in response to Daudi lymphoma and confer anti-tumour immunity

(2010) V. MALKOVSKA et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Expansion of Highly Cytotoxic Human Natural Killer Cells for Cancer Cell Therapy

(2009) H. Fujisaki et al.   CANCER RESEARCH

Predicting Circulating Human Metabolites: How Good Are We?

(2009) Shelby Anderson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pulmonary Passage is a Major Obstacle for Intravenous Stem Cell Delivery: The Pulmonary First-Pass Effect

(2008) Uwe M. Fischer et al.   STEM CELLS AND DEVELOPMENT

Toward Development and Production of Human T Cells in Swine for Potential Use in Adoptive T Cell Immunotherapy

(2008) Brenda M. Ogle et al.   TISSUE ENGINEERING PART A

Interleukin‐4–Transgenic hu‐PBL‐SCID Mice: A Model for the Screening of Antiviral Drugs and Immunotherapeutic Agents against X4 HIV‐1 Viruses

(2007) Kazu Okuma et al.   JOURNAL OF INFECTIOUS DISEASES