Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation

HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3

(2016) K Yuan et al.   CELL DEATH AND DIFFERENTIATION

Hepatocellular carcinoma and lifestyles

(2016) Uttara Saran et al.   JOURNAL OF HEPATOLOGY

Upregulation of Cytosolic Phosphoenolpyruvate Carboxykinase Is a Critical Metabolic Event in Melanoma Cells That Repopulate Tumors

(2015) Y. Li et al.   CANCER RESEARCH

Enhancement of Hypothalamic STAT3 Acetylation by Nuclear Receptor Nur77 Dictates Leptin Sensitivity

(2015) Yan Chen et al.   DIABETES

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth

(2015) Emily D. Montal et al.   MOLECULAR CELL

Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation

(2015) Li Li et al.   Nature Chemical Biology

Gluconeogenesis combats cancer: opening new doors in cancer biology

(2015) M W Khan et al.   Cell Death & Disease

Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue – a review

(2014) Nickolay Fedchenko et al.   Diagnostic Pathology

Fructose-1,6-bisphosphatase opposes renal carcinoma progression

(2014) Bo Li et al.   NATURE

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gluconeogenesis in cancer: Door wide open

(2014) Katharina Leithner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

(2014) P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK-M) and glucose homeostasis: Has it been overlooked?

(2013) Romana Stark et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

(2013) Chenfang Dong et al.   CANCER CELL

Ubc9 acetylation: a new route for achieving specificity in substrate SUMOylation

(2013) Shen-Hsi Yang et al.   EMBO JOURNAL

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

(2013) Wei-jia Wang et al.   Nature Chemical Biology

DNA methylation: roles in mammalian development

(2013) Zachary D. Smith et al.   NATURE REVIEWS GENETICS

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

(2012) Dianne H. Dapito et al.   CANCER CELL

S-adenosyl methionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers

(2012) Maria Lauda Tomasi et al.   HEPATOLOGY

Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice

(2012) Daisuke Kawai et al.   HEPATOLOGY

G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer

(2012) Chenfang Dong et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatocellular carcinoma

(2012) Alejandro Forner et al.   LANCET

High expression of p300 in HCC predicts shortened overall survival in association with enhanced epithelial mesenchymal transition of HCC cells

(2011) Chihiro Yokomizo et al.   CANCER LETTERS

Orphan receptor TR3 participates in cisplatin-induced apoptosis via Chk2 phosphorylation to repress intestinal tumorigenesis

(2011) Lu-ming Yao et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling

(2011) Hang-Zi Chen et al.   GUT

High expression of transcriptional coactivator p300 correlates with aggressive features and poor prognosis of hepatocellular carcinoma

(2011) Mei Li et al.   Journal of Translational Medicine

Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase

(2011) Wenqing Jiang et al.   MOLECULAR CELL

A Unique Metastasis Gene Signature Enables Prediction of Tumor Relapse in Early-Stage Hepatocellular Carcinoma Patients

(2010) S. Roessler et al.   CANCER RESEARCH

Enrichment of Nur77 mediated by retinoic acid receptor β leads to apoptosis of human hepatocellular carcinoma cells induced by fenretinide and histone deacetylase inhibitors

(2010) Hui Yang et al.   HEPATOLOGY

Is There Glucose Production Outside of the Liver and Kidney?

(2009) Stephen F. Previs et al.   Annual Review of Nutrition

Protein Acetylation Microarray Reveals that NuA4 Controls Key Metabolic Target Regulating Gluconeogenesis

(2009) Yu-yi Lin et al.   CELL

Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate

(2009) Isao Fukuda et al.   CHEMISTRY & BIOLOGY

Insulin Resistance and Altered Systemic Glucose Metabolism in Mice Lacking Nur77

(2009) Lily C. Chao et al.   DIABETES

Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma

(2009) Muh-Hwa Yang et al.   HEPATOLOGY

Aspects of the Control of Phosphoenolpyruvate Carboxykinase Gene Transcription

(2009) Jianqi Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An additional role for SUMO in ubiquitin-mediated proteolysis

(2009) Marie-Claude Geoffroy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Born to run; the story of the PEPCK-Cmus mouse

(2008) Richard W. Hanson et al.   BIOCHIMIE

Regulation of hepatic glucose production and the role of gluconeogenesis in humans: is the rate of gluconeogenesis constant?

(2008) Frank Q. Nuttall et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Cytosporone B is an agonist for nuclear orphan receptor Nur77

(2008) Yanyan Zhan et al.   Nature Chemical Biology