Alpha-Synuclein and Calpains Disrupt SNARE-Mediated Synaptic Vesicle Fusion During Manganese Exposure in SH-SY5Y Cells

Manganese-induced alpha-synuclein overexpression impairs synaptic vesicle fusion by disrupting the Rab3 cycle in primary cultured neurons

(2018) Tong-Yu Wang et al.   TOXICOLOGY LETTERS

Inhibition of Calpains Protects Mn-Induced Neurotransmitter release disorders in Synaptosomes from Mice: Involvement of SNARE Complex and Synaptic Vesicle Fusion

(2017) Can Wang et al.   Scientific Reports

Manganese exposure disrupts SNARE protein complex-mediated vesicle fusion in primary cultured neurons

(2016) Can Wang et al.   ENVIRONMENTAL TOXICOLOGY

The Influence of Manganese and Glutamine Intake on Antioxidants and Neurotransmitter Amino Acids Levels in Rats’ Brain

(2016) Maria Szpetnar et al.   NEUROCHEMICAL RESEARCH

α-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses

(2016) Naoto Sugeno et al.   Scientific Reports

Manganese rescues adverse effects on lifespan and development in Podospora anserina challenged by excess hydrogen peroxide

(2015) Carolin Grimm et al.   EXPERIMENTAL GERONTOLOGY

Neuronal copper homeostasis susceptibility by genetic defects in dysbindin, a schizophrenia susceptibility factor

(2015) Avanti Gokhale et al.   HUMAN MOLECULAR GENETICS

Co-immunoprecipitation of the Mouse Mx1 Protein with the Influenza A Virus Nucleoprotein

(2015) Judith Verhelst et al.   Jove-Journal of Visualized Experiments

Inhibition of Calpain Prevents Manganese-Induced Cell Injury and Alpha-Synuclein Oligomerization in Organotypic Brain Slice Cultures

(2015) Bin Xu et al.   PLoS One

Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo

(2014) Edward Rockenstein et al.   BRAIN

The protective role of tea polyphenols against methylmercury-induced neurotoxic effects in rat cerebral cortex via inhibition of oxidative stress

(2014) W. Liu et al.   FREE RADICAL RESEARCH

Ca2+–Calmodulin regulates SNARE assembly and spontaneous neurotransmitter release via v-ATPase subunit V0a1

(2014) Dong Wang et al.   JOURNAL OF CELL BIOLOGY

Three calpain isoforms are autolyzed in rat fast-twitch muscle after eccentric contractions

(2014) Keita Kanzaki et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Quantitative neuropathology associated with chronic manganese exposure in South African mine workers

(2014) Luis F. Gonzalez-Cuyar et al.   NEUROTOXICOLOGY

Correction: Acute Stress Increases Depolarization-Evoked Glutamate Release in the Rat Prefrontal/Frontal Cortex: The Dampening Action of Antidepressants

(2014) Laura Musazzi et al.   PLoS One

The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation

(2014) Yasuko Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA interference targeting α-synuclein attenuates methamphetamine-induced neurotoxicity in SH-SY5Y cells

(2013) Ling Chen et al.   BRAIN RESEARCH

Leptomeningeal Cells Transduce Peripheral Macrophages Inflammatory Signal to Microglia in Reponse toPorphyromonas gingivalisLPS

(2013) Yicong Liu et al.   MEDIATORS OF INFLAMMATION

Alpha-Synuclein is Involved in Manganese-Induced ER Stress via PERK Signal Pathway in Organotypic Brain Slice Cultures

(2013) Bin Xu et al.   MOLECULAR NEUROBIOLOGY

Sporadic Alzheimer’s Disease Begins as Episodes of Brain Ischemia and Ischemically Dysregulated Alzheimer’s Disease Genes

(2013) Ryszard Pluta et al.   MOLECULAR NEUROBIOLOGY

rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration

(2013) Marusela Oliveras-Salvá et al.   Molecular Neurodegeneration

Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle

(2013) Thomas C. Südhof   NEURON

Large  -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

(2013) B.-K. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress involvement in manganese-induced alpha-synuclein oligomerization in organotypic brain slice cultures

(2013) Bin Xu et al.   TOXICOLOGY

Molecular machines governing exocytosis of synaptic vesicles

(2012) Reinhard Jahn et al.   NATURE

Intranasal exposure to manganese disrupts neurotransmitter release from glutamatergic synapses in the central nervous system in vivo

(2012) Andrew H. Moberly et al.   NEUROTOXICOLOGY

Effect of Spermidine on Misfolding and Interactions of Alpha-Synuclein

(2012) Alexey V. Krasnoslobodtsev et al.   PLoS One

Impaired neurotransmission caused by overexpression of  -synuclein in nigral dopamine neurons

(2012) M. Lundblad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prolonged Exposure of Cortical Neurons to Oligomeric Amyloid-β Impairs NMDA Receptor Function Via NADPH Oxidase-Mediated ROS Production: Protective Effect of Green Tea (-)-Epigallocatechin-3-Gallate

(2011) Yan He et al.   ASN Neuro

Synaptic Vesicle Exocytosis

(2011) T. C. Sudhof et al.   Cold Spring Harbor Perspectives in Biology

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Effect of manganese exposure on intracellular Ca2+ homeostasis and expression of NMDA receptor subunits in primary cultured neurons

(2009) Bin Xu et al.   NEUROTOXICOLOGY

Oxidative damage and neurodegeneration in manganese-induced neurotoxicity

(2009) Dejan Milatovic et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Calpain activity contributes to the control of SNAP-25 levels in neurons

(2008) Carlotta Grumelli et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research

(2008) Yuen-Ting Cheung et al.   NEUROTOXICOLOGY