Oxymatrine Attenuates Tumor Growth and Deactivates STAT5 Signaling in a Lung Cancer Xenograft Model

Pan-HDAC inhibition by panobinostat mediates chemosensitization to carboplatin in non-small cell lung cancer via attenuation of EGFR signaling

(2018) Lingzhi Wang et al.   CANCER LETTERS

Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model

(2018) Chulwon Kim et al.   CANCER LETTERS

Pharmacologic inhibition of STAT5 in acute myeloid leukemia

(2018) Bettina Wingelhofer et al.   LEUKEMIA

Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer

(2018) Bettina Wingelhofer et al.   LEUKEMIA

Bergamottin Suppresses Metastasis of Lung Cancer Cells through Abrogation of Diverse Oncogenic Signaling Cascades and Epithelial-to-Mesenchymal Transition

(2018) Jeong-Hyeon Ko et al.   MOLECULES

Oxymatrine induces cell cycle arrest and apoptosis and suppresses the invasion of human glioblastoma cells through the EGFR/PI3K/Akt/mTOR signaling pathway and STAT3

(2018) Zhibo Dai et al.   ONCOLOGY REPORTS

Targeting activator protein 1 signaling pathway by bioactive natural agents: Possible therapeutic strategy for cancer prevention and intervention

(2018) Devesh Tewari et al.   PHARMACOLOGICAL RESEARCH

Ophiopogonin D modulates multiple oncogenic signaling pathways, leading to suppression of proliferation and chemosensitization of human lung cancer cells

(2018) Jong Hyun Lee et al.   PHYTOMEDICINE

Anti-myeloma Effects of Icariin Are Mediated Through the Attenuation of JAK/STAT3-Dependent Signaling Cascade

(2018) Young Yun Jung et al.   Frontiers in Pharmacology

The Cooperative Relationship between STAT5 and Reactive Oxygen Species in Leukemia: Mechanism and Therapeutic Potential

(2018) Tian Mi et al.   Cancers

A functional in vitro assay for screening inhibitors of STAT5B phosphorylation

(2018) Elvin D. de Araujo et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Efficacy and Safety of Compound Kushen Injection on Patients with Advanced Colon Cancer: A Meta-Analysis of Randomized Controlled Trials

(2017) Lixiu Yu et al.   Evidence-based Complementary and Alternative Medicine

Do STAT3 inhibitors have potential in the future for cancer therapy?

(2017) Andrea L.A. Wong et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies

(2017) P Freund et al.   LEUKEMIA

Jak Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition

(2017) Bernd Groner et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Oxymatrine induces nasopharyngeal cancer cell death through inhibition of PI3K/AKT and NF-κB pathways

(2017) Zhili Ni et al.   Molecular Medicine Reports

Oxymatrine inhibits proliferation of human bladder cancer T24 cells by inducing apoptosis and cell cycle arrest

(2017) Shun Li et al.   Oncology Letters

Oxymatrine suppresses the growth and invasion of MG63 cells by up-regulating PTEN and promoting its nuclear translocation

(2017) Ming He et al.   Oncotarget

Oxymatrine inhibits non-small cell lung cancer via suppression of EGFR signaling pathway

(2017) Wei Li et al.   Cancer Medicine

Matrine alters microRNA expression profiles in SGC-7901 human gastric cancer cells

(2017) HAILONG LI et al.   ONCOLOGY REPORTS

Oxymatrine synergistically enhances antitumor activity of oxaliplatin in colon carcinoma through PI3K/AKT/mTOR pathway

(2016) Yan Liu et al.   APOPTOSIS

A novel combinatorial strategy using Seliciclib® and Belinostat® for eradication of non-small cell lung cancer via apoptosis induction and BID activation

(2016) Pei-Shi Ong et al.   CANCER LETTERS

Reduced apurinic/apyrimidinic endonuclease activity enhances the antitumor activity of oxymatrine in lung cancer cells

(2016) Zhiqiang Wang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Ginkgolic Acid Inhibits Invasion and Migration and TGF-β-Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation

(2016) Seung Ho Baek et al.   JOURNAL OF CELLULAR PHYSIOLOGY

STAT5 in Cancer and Immunity

(2016) Aradhana Rani et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Oxymatrine inhibits the proliferation of CaSki cells via downregulating HPV16E7 expression

(2016) ZHIJUN PEI et al.   ONCOLOGY REPORTS

Oxymatrine inhibits the migration of human colorectal carcinoma RKO cells via inhibition of PAI-1 and the TGF-β1/Smad signaling pathway

(2016) Xiaoyu Wang et al.   ONCOLOGY REPORTS

Bioactive natural products in cancer prevention and therapy: Progress and promise

(2016) Anupam Bishayee et al.   SEMINARS IN CANCER BIOLOGY

Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds

(2016) Muthu K Shanmugam et al.   SEMINARS IN CANCER BIOLOGY

Targeting arachidonic acid pathway by natural products for cancer prevention and therapy

(2016) Nagendra Sastry Yarla et al.   SEMINARS IN CANCER BIOLOGY

Capsazepine inhibits JAK/STAT3 signaling, tumor growth, and cell survival in prostate cancer

(2016) Jong Hyun Lee et al.   Oncotarget

Oncogenic STAT5 signaling promotes oxidative stress in chronic myeloid leukemia cells by repressing antioxidant defenses

(2016) Jerome Bourgeais et al.   Oncotarget

Oxymatrine Inhibits Proliferation and Migration While Inducing Apoptosis in Human Glioblastoma Cells

(2016) Feili Liu et al.   Biomed Research International

HMGB1-mediated autophagy decreases sensitivity to oxymatrine in SW982 human synovial sarcoma cells

(2016) Yongsong Cai et al.   Scientific Reports

Anti-tumor activities of active ingredients in Compound Kushen Injection

(2015) Wei Wang et al.   ACTA PHARMACOLOGICA SINICA

Oxymatrine inhibited cell proliferation by inducing apoptosis in human lung cancer A549 cells

(2015) Baiyan Wang et al.   BIO-MEDICAL MATERIALS AND ENGINEERING

The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours

(2015) S J Thomas et al.   BRITISH JOURNAL OF CANCER

Farnesol inhibits tumor growth and enhances the anticancer effects of bortezomib in multiple myeloma xenograft mouse model through the modulation of STAT3 signaling pathway

(2015) Jong Hyun Lee et al.   CANCER LETTERS

Oxymatrine suppresses proliferation and induces apoptosis of hemangioma cells through inhibition of HIF-1a signaling

(2015) Z-W Fei et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Oxymatrine suppresses proliferation and facilitates apoptosis of human ovarian cancer cells through upregulating microRNA-29b and downregulating matrix metalloproteinase-2 expression

(2015) JINGWEI LI et al.   Molecular Medicine Reports

MicroRNA-10a silencing reverses cisplatin resistance in the A549/cisplatin human lung cancer cell line via the transforming growth factor-β/Smad2/STAT3/STAT5 pathway

(2015) WEI SUN et al.   Molecular Medicine Reports

Oxymatrine inhibits the proliferation of prostate cancer cells in vitro and in vivo

(2015) CUNZAO WU et al.   Molecular Medicine Reports

Oxymatrine synergistically enhances the inhibitory effect of 5-fluorouracil on hepatocellular carcinoma in vitro and in vivo

(2015) Yan Liu et al.   TUMOR BIOLOGY

Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells

(2015) Can Küçük et al.   Nature Communications

Artesunate suppresses tumor growth and induces apoptosis through the modulation of multiple oncogenic cascades in a chronic myeloid leukemia xenograft mouse model

(2015) Chulwon Kim et al.   Oncotarget

Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel

(2015) Jong Hyun Lee et al.   Oncotarget

Oxymatrine DownregulatesHPV16E7Expression and Inhibits Cell Proliferation in Laryngeal Squamous Cell Carcinoma Hep-2 Cells In Vitro

(2015) Xin-Jiang Ying et al.   Biomed Research International

Natural Bioactives in Cancer Treatment and Prevention

(2015) Yih-Shou Hsieh et al.   Biomed Research International

Stat5 Exerts Distinct, Vital Functions in the Cytoplasm and Nucleus of Bcr-Abl+ K562 and Jak2(V617F)+ HEL Leukemia Cells

(2015) Axel Weber et al.   Cancers

Inhibition of STAT5: A therapeutic option in BCR-ABL1-driven leukemia

(2015) Angelika Berger et al.   Oncotarget

Effects of oxymatrine on the apoptosis and proliferation of gallbladder cancer cells

(2014) Xiang-Song Wu et al.   ANTI-CANCER DRUGS

Oxymatrine targets EGFRp-Tyr845 and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells

(2014) Bingyu Guo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Oxymatrine Extracted from Sophora flavescens Inhibited Cell Growth and Induced Apoptosis in Human Osteosarcoma MG-63 Cells In Vitro

(2014) Jianghua Wei et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy

(2014) S. Bibi et al.   HAEMATOLOGICA

The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse

(2014) O. R. Bandapalli et al.   HAEMATOLOGICA

Stat5 Regulates the Phosphatidylinositol 3-Kinase/Akt1 Pathway during Mammary Gland Development and Tumorigenesis

(2014) J. W. Schmidt et al.   MOLECULAR AND CELLULAR BIOLOGY

Expression of STAT5, COX-2 and PIAS3 in Correlation with NSCLC Histhopathological Features

(2014) Dorota Pastuszak-Lewandoska et al.   PLoS One

Anti-tumor activities of matrine and oxymatrine: literature review

(2014) Yan Liu et al.   TUMOR BIOLOGY

Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein

(2014) Abbarna A. Cumaraswamy et al.   ACS Medicinal Chemistry Letters

STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b

(2014) Sarah Walker et al.   Cancers

Oxymatrine induces apoptosis in human cervical cancer cells through guanine nucleotide depletion

(2013) Mu Li et al.   ANTI-CANCER DRUGS

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Epidemiology of Lung Cancer

(2013) Anthony J. Alberg et al.   CHEST

Therapeutic Applications of Herbal Medicines for Cancer Patients

(2013) Shu-Yi Yin et al.   Evidence-based Complementary and Alternative Medicine

Natural Bioactives and Phytochemicals Serve in Cancer Treatment and Prevention

(2013) Shun-Fa Yang et al.   Evidence-based Complementary and Alternative Medicine

Dynamic trafficking of STAT5 depends on an unconventional nuclear localization signal

(2013) H. Y. Shin et al.   JOURNAL OF CELL SCIENCE

STAT inhibitors for cancer therapy

(2013) Muhammad Furqan et al.   Journal of Hematology & Oncology

Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer

(2013) Sarah R. Walker et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Antiangiogenic effects of oxymatrine on pancreatic cancer by inhibition of the NF-κB-mediated VEGF signaling pathway

(2013) HUI CHEN et al.   ONCOLOGY REPORTS

Oxymatrine induces mitochondria dependent apoptosis in human osteosarcoma MNNG/HOS cells through inhibition of PI3K/Akt pathway

(2013) Yong Zhang et al.   TUMOR BIOLOGY

Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF-κB signaling pathway

(2013) HONGMIN SHAO et al.   Oncology Letters

JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer

(2012) Adrian Britschgi et al.   CANCER CELL

Matrine Inhibits Breast Cancer Growth ViamiR-21/PTEN/AktPathway in MCF-7 Cells

(2012) Lin-Qiang Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Antitumor Activities of Kushen: Literature Review

(2012) Mingyu Sun et al.   Evidence-based Complementary and Alternative Medicine

Nuclear Stat5a/b predicts early recurrence and prostate cancer–specific death in patients treated by radical prostatectomy

(2012) Tuomas Mirtti et al.   HUMAN PATHOLOGY

Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c

(2011) Qi Ling et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting Cell Signaling and Apoptotic Pathways by Dietary Agents: Role in the Prevention and Treatment of Cancer

(2011) Muthu Shanmugam et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Effects of Oxymatrine on the apoptosis of human esophageal carcinoma Eca109 cell line and its mechanism

(2010) Yi Jin et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Oxymatrine diminishes the side population and inhibits the expression of β-catenin in MCF-7 breast cancer cells

(2010) Ying Zhang et al.   MEDICAL ONCOLOGY

Mammary Epithelial Reconstitution with Gene-Modified Stem Cells Assigns Roles to Stat5 in Luminal Alveolar Cell Fate Decisions, Differentiation, Involution and Mammary Tumor Formation

(2010) Vida Vafaizadeh et al.   STEM CELLS

Perspectives for Cancer Prevention With Natural Compounds

(2009) A.R.M. Ruhul Amin et al.   JOURNAL OF CLINICAL ONCOLOGY

Matrine induces apoptosis in gastric carcinoma cells via alteration of Fas/FasL and activation of caspase-3

(2009) Zhi-jun Dai et al.   JOURNAL OF ETHNOPHARMACOLOGY