Glioblastoma’s Next Top Model: Novel Culture Systems for Brain Cancer Radiotherapy Research

An advanced glioma cell invasion assay based on organotypic brain slice cultures

(2018) Tanja Eisemann et al.   BMC CANCER

HPV Screening and Vaccination Strategies in an Unscreened Population: A Mathematical Modeling Study

(2018) Rachael M. Milwid et al.   BULLETIN OF MATHEMATICAL BIOLOGY

Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors

(2018) Marat S. Pavlyukov et al.   CANCER CELL

Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression

(2018) Xiuxing Wang et al.   Cell Stem Cell

Combinatorial Drug Testing in 3D Microtumors Derived from GBM Patient-Derived Xenografts Reveals Cytotoxic Synergy in Pharmacokinomics-informed Pathway Interactions

(2018) Ashley N. Gilbert et al.   Scientific Reports

Scalable Culturing of Primary Human Glioblastoma Tumor-Initiating Cells with a Cell-Friendly Culture System

(2018) Qiang Li et al.   Scientific Reports

Glioblastoma Model Using Human Cerebral Organoids

(2018) Junko Ogawa et al.   Cell Reports

Cell density overrides the effect of substrate stiffness on human mesenchymal stem cells’ morphology and proliferation

(2018) Balu Venugopal et al.   Biomaterials Science

Drug Screening of Human GBM Spheroids in Brain Cancer Chip

(2018) Metin Akay et al.   Scientific Reports

In situ generation of human brain organoids on a micropillar array

(2017) Yujuan Zhu et al.   LAB ON A CHIP

The Combined Influence of Hydrogel Stiffness and Matrix-Bound Hyaluronic Acid Content on Glioblastoma Invasion

(2017) Jee-Wei Emily Chen et al.   MACROMOLECULAR BIOSCIENCE

Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

(2017) Humsa S. Venkatesh et al.   NATURE

Patient-derived xenografts undergo mouse-specific tumor evolution

(2017) Uri Ben-David et al.   NATURE GENETICS

The use of brain organoids to investigate neural development and disease

(2017) Elizabeth Di Lullo et al.   NATURE REVIEWS NEUROSCIENCE

Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas

(2017) Sophie Weil et al.   NEURO-ONCOLOGY

Monoamines in glioblastoma: complex biology with therapeutic potential

(2017) Seamus Patrick Caragher et al.   NEURO-ONCOLOGY

EGFR heterogeneity and implications for therapeutic intervention in glioblastoma

(2017) Eskil Eskilsson et al.   NEURO-ONCOLOGY

Culture conditions defining glioblastoma cells behavior: what is the impact for novel discoveries?

(2017) Pítia Flores Ledur et al.   Oncotarget

Metabolic alterations underlying Bevacizumab therapy in glioblastoma cells

(2017) Vera Miranda-Gonçalves et al.   Oncotarget

Extracellular Hyaluronic Acid Influences the Efficacy of EGFR Tyrosine Kinase Inhibitors in a Biomaterial Model of Glioblastoma

(2017) Sara Pedron et al.   Advanced Healthcare Materials

Substrate stiffness influences phenotype and function of human antigen-presenting dendritic cells

(2017) Svenja F. B. Mennens et al.   Scientific Reports

An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers

(2016) Genaro R. Villa et al.   CANCER CELL

A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo

(2016) Christopher G. Hubert et al.   CANCER RESEARCH

Myc-Driven Glycolysis Is a Therapeutic Target in Glioblastoma

(2016) K. Tateishi et al.   CLINICAL CANCER RESEARCH

Radiation-Induced Dedifferentiation of Head and Neck Cancer Cells Into Cancer Stem Cells Depends on Human Papillomavirus Status

(2016) Erina Vlashi et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Dedifferentiation of Glioma Cells to Glioma Stem-like Cells By Therapeutic Stress-induced HIF Signaling in the Recurrent GBM Model

(2016) Gina Lee et al.   MOLECULAR CANCER THERAPEUTICS

Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression

(2016) Yekaterina A. Miroshnikova et al.   NATURE CELL BIOLOGY

The promises and challenges of human brain organoids as models of neuropsychiatric disease

(2016) Giorgia Quadrato et al.   NATURE MEDICINE

A novel 3D human glioblastoma cell culture system for modeling drug and radiation responses

(2016) Natividad Gomez-Roman et al.   NEURO-ONCOLOGY

Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model

(2016) Onyinyechukwu Okolie et al.   NEURO-ONCOLOGY

Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells

(2016) Hua Lin et al.   NEURO-ONCOLOGY

Origin of the U87MG glioma cell line: Good news and bad news

(2016) Marie Allen et al.   Science Translational Medicine

Preclinical Data on Efficacy of 10 Drug-Radiation Combinations: Evaluations, Concerns, and Recommendations

(2016) Helen B. Stone et al.   Translational Oncology

Cancer stem cells from human glioblastoma resemble but do not mimic original tumors after in vitro passaging in serum-free media

(2016) Noemí García-Romero et al.   Oncotarget

A three-dimensional collagen scaffold cell culture system for screening anti-glioma therapeutics

(2016) Donglai Lv et al.   Oncotarget

Differential response of patient-derived primary glioblastoma cells to environmental stiffness

(2016) Thomas James Grundy et al.   Scientific Reports

Metabolic/Proteomic Signature Defines Two Glioblastoma Subtypes With Different Clinical Outcome

(2016) G. Marziali et al.   Scientific Reports

Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion

(2015) Humsa S. Venkatesh et al.   CELL

Overcoming the blood–brain tumor barrier for effective glioblastoma treatment

(2015) O. van Tellingen et al.   DRUG RESISTANCE UPDATES

Dedifferentiation of patient-derived glioblastoma multiforme cell lines results in a cancer stem cell-like state with mitogen-independent growth

(2015) Inan Olmez et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Immunosuppressive mechanisms in glioblastoma: Fig. 1.

(2015) Edjah K. Nduom et al.   NEURO-ONCOLOGY

EGFR and β1-integrin targeting differentially affect colorectal carcinoma cell radiosensitivity and invasion

(2015) Mandy Poschau et al.   RADIOTHERAPY AND ONCOLOGY

Extracellular Matrix Properties Regulate the Migratory Response of Glioblastoma Stem Cells in Three-Dimensional Culture

(2015) Marisol Herrera-Perez et al.   TISSUE ENGINEERING PART A

Coculture with astrocytes reduces the radiosensitivity of glioblastoma stem-like cells and identifies additional targets for radiosensitization

(2015) Barbara H. Rath et al.   Cancer Medicine

Engineering strategies to mimic the glioblastoma microenvironment

(2014) Andrew Rape et al.   ADVANCED DRUG DELIVERY REVIEWS

Spatially Gradated Hydrogel Platform as a 3D Engineered Tumor Microenvironment

(2014) Sara Pedron et al.   ADVANCED MATERIALS

Bioengineered Scaffolds for 3D Analysis of Glioblastoma Proliferation and Invasion

(2014) John M. Heffernan et al.   ANNALS OF BIOMEDICAL ENGINEERING

Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis

(2014) Manuel Valiente et al.   CELL

Bioengineered 3D Brain Tumor Model To Elucidate the Effects of Matrix Stiffness on Glioblastoma Cell Behavior Using PEG-Based Hydrogels

(2014) Christine Wang et al.   MOLECULAR PHARMACEUTICS

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance

(2014) P Dahan et al.   Cell Death & Disease

Glioblastoma Behaviors in Three-Dimensional Collagen-Hyaluronan Composite Hydrogels

(2013) Shreyas S. Rao et al.   ACS Applied Materials & Interfaces

Porous chitosan-hyaluronic acid scaffolds as a mimic of glioblastoma microenvironment ECM

(2013) Stephen J. Florczyk et al.   BIOMATERIALS

Regulation of glioma cell phenotype in 3D matrices by hyaluronic acid

(2013) Sara Pedron et al.   BIOMATERIALS

Cerebral Organoids in a Dish: Progress and Prospects

(2013) Marina Bershteyn et al.   CELL

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

(2013) Kenta Masui et al.   Cell Metabolism

Ex vivo cultures of glioblastoma in three-dimensional hydrogel maintain the original tumor growth behavior and are suitable for preclinical drug and radiation sensitivity screening

(2013) Carine Jiguet Jiglaire et al.   EXPERIMENTAL CELL RESEARCH

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

(2013) William A Flavahan et al.   NATURE NEUROSCIENCE

Glioma Spheroids Obtained via Ultrasonic Aspiration Are Viable and Express Stem Cell Markers

(2013) Stine Skov Jensen et al.   NEUROSURGERY

Impact of the 3D Microenvironment on Phenotype, Gene Expression, and EGFR Inhibition of Colorectal Cancer Cell Lines

(2013) Anna C. Luca et al.   PLoS One

Astrocytes Enhance the Invasion Potential of Glioblastoma Stem-Like Cells

(2013) Barbara H. Rath et al.   PLoS One

Sugar for the brain: the role of glucose in physiological and pathological brain function

(2013) Philipp Mergenthaler et al.   TRENDS IN NEUROSCIENCES

Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma

(2012) Y.-L. Hu et al.   CANCER RESEARCH

Tumor-Associated Microglia/Macrophages Enhance the Invasion of Glioma Stem-like Cells via TGF- 1 Signaling Pathway

(2012) X.-z. Ye et al.   JOURNAL OF IMMUNOLOGY

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(2012) Salvatore Coniglio et al.   MOLECULAR MEDICINE

Allen Brain Atlas: an integrated spatio-temporal portal for exploring the central nervous system

(2012) Susan M. Sunkin et al.   NUCLEIC ACIDS RESEARCH

Genome-Wide Gene Expression Analysis in Cancer Cells Reveals 3D Growth to Affect ECM and Processes Associated with Cell Adhesion but Not DNA Repair

(2012) Oliver Zschenker et al.   PLoS One

Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform

(2011) Badriprasad Ananthanarayanan et al.   BIOMATERIALS

Mosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma

(2011) Matija Snuderl et al.   CANCER CELL

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glutamate release by primary brain tumors induces epileptic activity

(2011) Susan C Buckingham et al.   NATURE MEDICINE

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma

(2011) Olivier Keunen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification

(2010) K. Storch et al.   CANCER RESEARCH

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

(2010) John M. Heddleston et al.   CELL CYCLE

Acidic stress promotes a glioma stem cell phenotype

(2010) A B Hjelmeland et al.   CELL DEATH AND DIFFERENTIATION

Microglia/macrophages promote glioma progression

(2010) Haiyan Zhai et al.   GLIA

Matrigel: A complex protein mixture required for optimal growth of cell culture

(2010) Chris S. Hughes et al.   PROTEOMICS

Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis and Vasculogenesis via Vascular Endothelial Growth Factor and Stromal-Derived Factor 1

(2009) C. Folkins et al.   CANCER RESEARCH

Organotypic glioma spheroids for screening of experimental therapies: How many spheroids and sections are required?

(2009) Philip C. De Witt Hamer et al.   CYTOMETRY PART A

Neuroscience: Glia — more than just brain glue

(2009) Nicola J. Allen et al.   NATURE

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α

(2009) A Soeda et al.   ONCOGENE

Glutamate Promotes Cell Growth by EGFR Signaling on U-87MG Human Glioblastoma Cell Line

(2009) Daniel Pretto Schunemann et al.   PATHOLOGY & ONCOLOGY RESEARCH

3D cell cultures of human head and neck squamous cell carcinoma cells are radiosensitized by the focal adhesion kinase inhibitor TAE226

(2009) Stephanie Hehlgans et al.   RADIOTHERAPY AND ONCOLOGY

Histone Deacetylase Inhibition and Blockade of the Glycolytic Pathway Synergistically Induce Glioblastoma Cell Death

(2008) V. Egler et al.   CLINICAL CANCER RESEARCH

Regional Hypoxia in Glioblastoma Multiforme Quantified with [18F]Fluoromisonidazole Positron Emission Tomography before Radiotherapy: Correlation with Time to Progression and Survival

(2008) A. M. Spence et al.   CLINICAL CANCER RESEARCH

Angiogenesis in gliomas.

(2008) Agnieszka Lebelt et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours

(2008) Talal M. Fael Al-Mayhani et al.   JOURNAL OF NEUROSCIENCE METHODS

Presynaptic glutamate receptors: physiological functions and mechanisms of action

(2008) Paulo S. Pinheiro et al.   NATURE REVIEWS NEUROSCIENCE