Engineering human megakaryocytic microparticles for targeted delivery of nucleic acids to hematopoietic stem and progenitor cells

How do megakaryocytic microparticles target and deliver cargo to alter the fate of hematopoietic stem cells?

(2017) Jinlin Jiang et al.   JOURNAL OF CONTROLLED RELEASE

Gene Editing of Human Hematopoietic Stem and Progenitor Cells: Promise and Potential Hurdles

(2016) Kyung-Rok Yu et al.   HUMAN GENE THERAPY

MYB controls erythroid versus megakaryocyte lineage fate decision through the miR-486-3p-mediated downregulation of MAF

(2015) E Bianchi et al.   CELL DEATH AND DIFFERENTIATION

Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

(2015) Gregor Fuhrmann et al.   JOURNAL OF CONTROLLED RELEASE

Exogenous DNA Loading into Extracellular Vesicles via Electroporation is Size-Dependent and Enables Limited Gene Delivery

(2015) Tek N. Lamichhane et al.   MOLECULAR PHARMACEUTICS

Differential fates of biomolecules delivered to target cells via extracellular vesicles

(2015) Masamitsu Kanada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-based, transient modulation of gene expression in human haematopoietic stem and progenitor cells

(2015) Yvonne Diener et al.   Scientific Reports

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Microvesicle-mediated delivery of transforming growth factor β1 siRNA for the suppression of tumor growth in mice

(2014) Yaqin Zhang et al.   BIOMATERIALS

MicroRNA-486 regulates normal erythropoiesis and enhances growth and modulates drug response in CML progenitors

(2014) L.-S. Wang et al.   BLOOD

Shear enhances thrombopoiesis and formation of microparticles that induce megakaryocytic differentiation of stem cells

(2014) J. Jiang et al.   BLOOD

Mesenchymal Stem Cell-Derived Microparticles: A Promising Therapeutic Strategy

(2014) Xi Tan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice

(2014) J. Mark Cooper et al.   MOVEMENT DISORDERS

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Endothelial microparticles: Sophisticated vesicles modulating vascular function

(2013) Anne M Curtis et al.   VASCULAR MEDICINE

Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo

(2012) N A McNeer et al.   GENE THERAPY

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

(2012) Arda Mizrak et al.   MOLECULAR THERAPY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

The Possible “Proton Sponge ” Effect of Polyethylenimine (PEI) Does Not Include Change in Lysosomal pH

(2012) Rikke V Benjaminsen et al.   MOLECULAR THERAPY

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

(2012) Jessica Wahlgren et al.   NUCLEIC ACIDS RESEARCH

Three-Stage Ex Vivo Expansion of High-Ploidy Megakaryocytic Cells: Toward Large-Scale Platelet Production

(2012) Swapna Panuganti et al.   TISSUE ENGINEERING PART A

Fluorescence-based evaluation of shRNA efficacy

(2011) B.J. Naughton et al.   ANALYTICAL BIOCHEMISTRY

Nucleofection induces non-specific changes in the metabolic activity of transfected cells

(2011) Fernanda Mello de Queiroz et al.   MOLECULAR BIOLOGY REPORTS

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Radius of gyration of plasmid DNA isoforms from static light scattering

(2010) David R. Latulippe et al.   BIOTECHNOLOGY AND BIOENGINEERING

c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression

(2010) E. Bianchi et al.   BLOOD

A guide to super-resolution fluorescence microscopy

(2010) Lothar Schermelleh et al.   JOURNAL OF CELL BIOLOGY

Microvesicle-mediated RNA Molecule Delivery System Using Monocytes/Macrophages

(2010) Yukihiro Akao et al.   MOLECULAR THERAPY

Nanoparticles Deliver Triplex-forming PNAs for Site-specific Genomic Recombination in CD34+ Human Hematopoietic Progenitors

(2010) Nicole A McNeer et al.   MOLECULAR THERAPY

Delivery of Macromolecules Using Arginine-Rich Cell-Penetrating Peptides: Ways to Overcome Endosomal Entrapment

(2009) Ayman El-Sayed et al.   AAPS Journal

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles

(2008) R. Flaumenhaft et al.   BLOOD