Article
Nutrition & Dietetics
Ana Rocio Rivera-Martinez, Itzen Aguiniga-Sanchez, Jorge Cadena-Iniguez, Isabel Soto-Cruz, Alberto Monroy-Garcia, Guadalupe Gomez-Garcia, Edgar Ledesma-Martinez, Benny Weiss-Steider, Edelmiro Santiago-Osorio
Summary: The wild species Sechium chinantlense (SCH) has been found to have antitumor properties, inhibiting proliferation in cervical cancer cells without harming normal cells.
Article
Pharmacology & Pharmacy
Marily Gonzalez-Castillo, Maria de Jesus Loera, Juan Ascacio-Valdes, Raul Rodriguez-Herrera, Alejandro Zugasti-Cruz, Mauricio Salinas-Santander, Ana Cecilia Cepeda-Nieto, Ileana Vera-Reyes, Mayela del Angel-Martinez, Antonio Morlett-Chavez
Summary: Polyphenols extracted from pomegranate peel were purified and evaluated for their cytotoxic effects on Hela and NIH-3T3 cell lines. Punicalagin and ellagic acid (EA) isolated from pomegranate peel were found to regulate apoptosis in Hela and NIH-3T3 cells, with concentration and exposure time playing a role in determining the cytotoxic effect. Results from a commercial assay kit suggest that punicalin and EA may regulate apoptosis in these cell lines by altering protein expression levels.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Feng Chen, Hong-Mei Wang, Ling-Qi Kong, Qin-Hua Chen, Li-Na Ke, He-Liu Dai, Xiao-Hua Zeng
Summary: Heterocyclic compounds, such as pyrrolidone, have been widely used and studied in various fields. In this study, a new fluorine-containing rhopaladins' analog called RPDPD was synthesized and evaluated for its anti-tumor activity in vitro. The results showed that RPDPD inhibited the proliferation of HeLa cells and induced apoptosis, possibly through the inhibition of E6 and E7 mRNA expressions and the modulation of the TIMP3/MMP3 signaling pathway.
FRONTIERS IN CHEMISTRY
(2022)
Article
Toxicology
Yogeswari Subramaniam, Kamalraj Subban, Jayabaskaran Chelliah
Summary: The study confirmed the presence of cholestanol glucoside (CG) and its synergy with paclitaxel (PTX) in inducing apoptosis of HeLa cells, showing strong cytotoxic effects and providing a potential therapeutic strategy for cancer treatment in the future.
TOXICOLOGY IN VITRO
(2021)
Article
Energy & Fuels
Sara Ghandehari, Mohammad Taghi Goodarzi, Jafar Izadi Nia, Masoud Homayouni Tabrizi
Summary: The aim of this study was to load kombucha-fermented extract (KFE) on PLGA nanoparticles (KFE-PNPs) to increase bioavailability and to evaluate its anti-cancer effects. The results showed that KFE-PNPs had stable nanoparticle characteristics, selectively killed cancer cells, promoted apoptosis, and inhibited angiogenesis.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Biochemistry & Molecular Biology
Arti Nile, Jisoo Shin, Juhyun Shin, Gyun Seok Park, Suhyun Lee, Ji-Ho Lee, Kyung-Woo Lee, Beob Gyun Kim, Sung Gu Han, Ramesh Kumar Saini, Jae-Wook Oh
Summary: This study investigated the effects of cinnamaldehyde-rich cinnamon extract (CRCE) on colorectal cancer cell lines HCT 116 and HT-29. The results showed that CRCE inhibited cell proliferation and migration, induced cell apoptosis, and activated apoptotic proteins. In addition, CRCE also induced mitochondrial stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Justyna Stefanowicz-Hajduk, Magdalena Gucwa, Barbara Moniuszko-Szajwaj, Anna Stochmal, Anna Kawiak, J. Renata Ochocka
Summary: The bufadienolide compound bersaldegenin-1,3,5-orthoacetate exhibits strong cytotoxicity against cervical cancer cells by inducing cell cycle arrest and caspase-independent cell death through double-stranded DNA damage and overproduction of reactive oxygen species. The compound also leads to the overexpression of NF-Kappa-B inhibitor genes in the treated cells. These findings provide important insights for further research on cell death signaling pathways induced by bufadienolides.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Food Science & Technology
Jiao Xu, Zhi-Cheng Tan, Zhong-Yuan Shen, Xing-Jia Shen, Shun-Ming Tang
Summary: The study demonstrated that polysaccharides from Cordyceps cicadae inhibited Hela cell proliferation and induced apoptosis by affecting cell cycle and apoptosis-related gene expression. This lays the foundation for extending the anti-cancer effects of natural plant resources with low toxicity and high efficiency.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Chemistry, Physical
Sumit Thakral, Devinder Kumar, Suman Rani, Ramesh Kataria, Poonam Sagar, Nitin Kumar Singhal
Summary: A library of 2'-aryl-2,5'-bibenzoxoles was synthesized and characterized. Compounds 8p, 8k, and 8t showed good cytotoxicity against cervical cancer cell lines.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Pharmacology & Pharmacy
Benjaporn Buranrat
Summary: Piper nigrum extract exhibited cytotoxic effects on cervical cancer cells, inhibiting cell proliferation and migration, and inducing apoptosis. This suggests that Piper nigrum may serve as a potential preventive or therapeutic agent for cervical cancer.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Nazia Afroze, Sreepoorna Pramodh, Abdulmajeed G. Almutary, Tahir A. Rizvi, Naushad Rais, Ritu Raina, Md Faiyazuddin, Abdullah M. Alnuqaydan, Arif Hussain
Summary: This study reveals that Kaempferol can induce apoptosis, reduce cell viability, and exhibit antioxidant and anti-inflammatory effects on HeLa cells. It also inhibits excessive cell division. Therefore, Kaempferol has the potential to serve as a natural therapeutic agent.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Takashi Amemiya, Kenichi Shibata, Junpei Takahashi, Masatoshi Watanabe, Satoshi Nakata, Kazuyuki Nakamura, Tomohiko Yamaguchi
Summary: Studies have shown that highly malignant cancer cells exhibit glycolytic oscillations with higher frequencies compared to less malignant cells. Adjacent cells in spheroids oscillate with minimal frequency differences, but do not synchronize with each other.
Article
Biochemistry & Molecular Biology
Changhong Li, Linli Zhang, Chengmei Liu, Xuemei He, Mingshun Chen, Jun Chen
Summary: This study investigates the anti-cervical cancer activity of lipophilic grape seed proanthocyanidin (LGSP). LGSP showed a significant anti-proliferative effect on HeLa cells by increasing reactive oxygen species, inducing cell apoptosis, and blocking cell cycle progression. It also effectively suppressed the growth of a HeLa xenograft tumor in a zebrafish model.
Article
Toxicology
Aysun Okcesiz Haciseyitoglu, Tugbagul Cal Dogan, Sevtap Aydin Dilsiz, Hande Canpinar, Ayse Eken, Ulku Undeger Bucurgat
Summary: This study aimed to investigate the effects of Pitavastatin alone and in combination with cisplatin on cervical cancer cells in vitro. The combined treatment of Pitavastatin with cisplatin resulted in significant inhibition of cell viability. Pitavastatin induced apoptosis and increased the expression of active caspase-9 and caspase-3.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Saad Mustafa, Jogendra Singh Pawar, Ilora Ghosh
Summary: The study found that Fucoidan induces cytotoxicity in HeLa cells through the generation of ROS and mitochondrial superoxide, as well as ATP loss. Additionally, Fucoidan disrupts HDAC function, leading to autophagy and cellular senescence.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Manaswini Dash, Subhashree Singh, Bhaskar Chandra Sahoo, Suprava Sahoo, Rajesh Kumar Sahoo, Sanghamitra Nayak, Basudeba Kar
Summary: The study analyzed the volatile components in Piper longum leaf and fruit, showing that the fruit volatiles had higher antioxidant and free radical scavenging activities, exhibiting strong activity against multidrug resistant bacteria, particularly Acinetobacter baumannii. Therefore, dried fruits may be used for drug development.
NATURAL PRODUCT RESEARCH
(2022)
Article
Plant Sciences
Pradeep Kumar Kamila, Asit Ray, Sudipta Jena, Ambika Sahoo, Subrat Kumar Kar, Sanghamitra Nayak, Pratap Chandra Panda
Summary: The study investigated the variation in yield and chemical composition of essential oil isolated from seven wild populations of Hypericum gaitii from Eastern India. The essential oils were found to contain a diverse range of chemical constituents, with distinct chemotypes identified based on principal component analysis and hierarchical clustering. The results suggest that geographical origin and environmental factors significantly influence the essential oil properties of H. gaitii.
Review
Plant Sciences
Bhaskar Chandra Sahoo, Suprava Sahoo, Sanghamitra Nayak, Basudeba Kar
Summary: Zingerone is a nonvolatile and nontoxic compound found in ginger, with multiple pharmacological activities such as antimicrobial, antioxidant, and anti-inflammatory effects. This review summarizes the diverse pharmacological activities of zingerone against important diseases like cancer, inflammation, and infection, and discusses its molecular regulation.
PLANT SCIENCE TODAY
(2022)
Article
Biochemistry & Molecular Biology
Subhashree Singh, Suprava Sahoo, Bhaskar Chandra Sahoo, Manaswini Dash, Sanghamitra Nayak, Basudeba Kar
Summary: The essential oil of Kaempferia galanga L., commonly known as sand ginger, has been in high demand in the national and international market. This study evaluated the essential oil yield and constituents of 36 accessions from three provinces in Eastern India. It identified quality chemovars that can be used for commercial cultivation and further improvement of the taxa.
Article
Biochemistry & Molecular Biology
Bibhuti Bhusan Champati, Bhuban Mohan Padhiari, Asit Ray, Tarun Halder, Sudipta Jena, Ambika Sahoo, Basudeba Kar, Pradeep Kumar Kamila, Pratap Chandra Panda, Biswajit Ghosh, Sanghamitra Nayak
Summary: This study used a multilayer perceptron artificial neural network to investigate the abiotic factors affecting the andrographolide content of Andrographis paniculata and select suitable cultivation sites with high andrographolide content. The results showed that nitrogen, phosphorus, and potassium were the predominant factors influencing the andrographolide content.
Article
Biochemistry & Molecular Biology
Sudipta Jena, Asit Ray, Omprakash Mohanta, Prabhat Kumar Das, Ambika Sahoo, Sanghamitra Nayak, Pratap Chandra Panda
Summary: The bark and leaf essential oils of Neocinnamomum caudatum exhibit anti-inflammatory properties, with the bark essential oil showing stronger effects. They could potentially be used as therapeutic agents for inflammatory diseases.
Article
Biochemistry & Molecular Biology
Shibani Mohapatra, Saumya Ranjan Barik, Prasanta K. Dash, Devidutta Lenka, Kartika Chandra Pradhan, K. R. Reshmi Raj, Shakti Prakash Mohanty, Mihir Ranjan Mohanty, Ambika Sahoo, Binod Kumar Jena, Alok Kumar Panda, Debabrata Panigrahi, Sushanta Kumar Dash, Jitendriya Meher, Chitta Ranjan Sahoo, Arup Kumar Mukherjee, Lipi Das, Lambodar Behera, Sharat Kumar Pradhan
Summary: Ranidhan, a popular rice variety in Odisha state, India, is prone to damage from flash floods and susceptible to bacterial blight disease. In order to enhance its resistance and submergence tolerance, researchers used marker-assisted backcross breeding to introduce BB resistance genes and submergence tolerance genes into Ranidhan. Through selection and backcrossing, a new rice variety with high resistance and similar qualities to Ranidhan was developed.
Article
Plant Sciences
Bibhuti Bhusan Champati, Bhuban Mohan Padhiari, Asit Ray, Sudipta Jena, Ambika Sahoo, Tirthabrata Sahoo, Pratap Chandra Panda, Sanghamitra Nayak
Summary: This study conducted qualitative and quantitative analysis of Shatavarin IV in marketed products of A. racemosus using HPTLC. The results showed the presence of Shatavarin IV in all of the analyzed products, and its amount varied within a normal range. These findings can serve as a reference for future quality assessment of commercial A. racemosus products.
PLANT SCIENCE TODAY
(2023)
Article
Chemistry, Medicinal
Sudipta Jena, Asit Ray, Ambika Sahoo, Prabhat Kumar Das, Bibhuti Bhusan Champati, Sanghamitra Nayak, Pratap Chandra Panda
CHEMISTRY OF NATURAL COMPOUNDS
(2022)