CD69 Is the Crucial Regulator of Intestinal Inflammation: A New Target Molecule for IBD Treatment?

Identification of inflammatory mediators in patients with Crohn's disease unresponsive to anti-TNFα therapy

(2014) Raquel Franco Leal et al.   GUT

Imprinting of CCR9 on CD4 T Cells Requires IL-4 Signaling on Mesenteric Lymph Node Dendritic Cells

(2014) R. Elgueta et al.   JOURNAL OF IMMUNOLOGY

CD69+CD4+CD25- T Cells, a New Subset of Regulatory T Cells, Suppress T Cell Proliferation through Membrane-Bound TGF- 1

(2014) Y. Han et al.   JOURNAL OF IMMUNOLOGY

Infectious and Malignant Complications of TNF Inhibitor Therapy in IBD

(2013) Laura E Targownik et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Treatment of inflammatory bowel disease by chemokine receptor-targeted leukapheresis

(2013) Michael Eberhardson et al.   CLINICAL IMMUNOLOGY

Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation

(2013) M Zaeem Cader et al.   GUT

Transforming Growth Factor-β Signaling Controls the Formation and Maintenance of Gut-Resident Memory T Cells by Regulating Migration and Retention

(2013) Nu Zhang et al.   IMMUNITY

Ca2+-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin E

(2013) Daopeng Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypertrophy of infected Peyer’s patches arises from global, interferon-receptor and CD69-independent shutdown of lymphocyte egress

(2013) O Schulz et al.   Mucosal Immunology

Lung niches for the generation and maintenance of tissue-resident memory T cells

(2013) D L Turner et al.   Mucosal Immunology

Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease

(2013) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Curcumin Inhibits CD4+ T Cell Activation, but Augments CD69 Expression and TGF-β1-Mediated Generation of Regulatory T Cells at Late Phase

(2013) Girak Kim et al.   PLoS One

Crucial Role for CD69 in the Pathogenesis of Dextran Sulphate Sodium-Induced Colitis

(2013) Akihiro Hasegawa et al.   PLoS One

The Early Activation Marker CD69 Regulates the Expression of Chemokines and CD4 T Cell Accumulation in Intestine

(2013) Katarina Radulovic et al.   PLoS One

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

(2013) M. Shan et al.   SCIENCE

Is CD69 an effective brake to control inflammatory diseases?

(2013) Roberto González-Amaro et al.   TRENDS IN MOLECULAR MEDICINE

CD49b/CD69-Dependent Generation of Resting T Helper Cell Memory

(2013) Asami Hanazawa et al.   Frontiers in Immunology

High frequency of CD4+CD25−CD69+T cells is correlated with a low risk of acute graft-versus-host disease in allotransplants

(2012) Sheng-Ye Lu et al.   CLINICAL TRANSPLANTATION

Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity

(2012) Divya Sekar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets

(2012) Taheri Sathaliyawala et al.   IMMUNITY

Recirculating Memory T Cells Are a Unique Subset of CD4+ T Cells with a Distinct Phenotype and Migratory Pattern

(2012) S. K. Bromley et al.   JOURNAL OF IMMUNOLOGY

CD69 Regulates Type I IFN-Induced Tolerogenic Signals to Mucosal CD4 T Cells That Attenuate Their Colitogenic Potential

(2012) K. Radulovic et al.   JOURNAL OF IMMUNOLOGY

Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in Tissues

(2012) K. A. Casey et al.   JOURNAL OF IMMUNOLOGY

Intestinal intraepithelial TCRγδ+ T cells are activated by normal commensal bacteria

(2012) Sang Phil Jeong et al.   JOURNAL OF MICROBIOLOGY

Guarding the perimeter: protection of the mucosa by tissue-resident memory T cells

(2012) L S Cauley et al.   Mucosal Immunology

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

(2012) Jeremiah R. McDole et al.   NATURE

CD69 Does Not Affect the Extent of T Cell Priming

(2012) Elisenda Alari-Pahissa et al.   PLoS One

Type II membrane protein CD69 regulates the formation of resting T-helper memory

(2012) K. Shinoda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enterocytes: active cells in tolerance to food and microbial antigens in the gut

(2011) N. Miron et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina Propria

(2011) Usriansyah Hadis et al.   IMMUNITY

Innate immune signaling in defense against intestinal microbes

(2011) Melissa A. Kinnebrew et al.   IMMUNOLOGICAL REVIEWS

Mesenchymal stem cells promote the sustained expression of CD69 on activated T lymphocytes: roles of canonical and non-canonical NF-κB signalling

(2011) Felipe Saldanha-Araujo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice

(2011) Swantje I. Hammerschmidt et al.   JOURNAL OF CLINICAL INVESTIGATION

Are non-traditional CD4+CD69+CD25- regulatory T cells involved in disease progression of human hepatocellular carcinoma?

(2011) Dongping Xu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Increased CD4+CD69+CD25- T cells in patients with hepatocellular carcinoma are associated with tumor progression

(2011) Jiankang Zhu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Environmental and Antigen Receptor-Derived Signals Support Sustained Surveillance of the Lungs by Pathogen-Specific Cytotoxic T Lymphocytes

(2011) Y.-T. Lee et al.   JOURNAL OF VIROLOGY

Mucin dynamics and enteric pathogens

(2011) Michael A. McGuckin et al.   NATURE REVIEWS MICROBIOLOGY

Identification of M.tuberculosis-Specific Th1 Cells Expressing CD69 Generated in vivo in Pleural Fluid Cells from Patients with Tuberculous Pleurisy

(2011) Li Li et al.   PLoS One

Induction of CD69 expression bycagPAI-positiveHelicobacter pyloriinfection

(2011) Naoki Mori   WORLD JOURNAL OF GASTROENTEROLOGY

Adaptive T-cell responses regulating oral tolerance to protein antigen

(2010) M. F. du Pré et al.   ALLERGY

Soluble VEGFR-2: an antilymphangiogenic variant of VEGF receptors

(2010) Helena Pavlakovic et al.   Annals of the New York Academy of Sciences

Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development

(2010) E. Martin-Gayo et al.   BLOOD

Homeostasis and Inflammation in the Intestine

(2010) Wendy S. Garrett et al.   CELL

CD69 Limits the Severity of Cardiomyopathy After Autoimmune Myocarditis

(2010) Aranzazu Cruz-Adalia et al.   CIRCULATION

Mucosal T cells in gut homeostasis and inflammation

(2010) Femke van Wijk et al.   Expert Review of Clinical Immunology

CD69 limits early inflammatory diseases associated with immune response to Listeria monocytogenes infection

(2010) Javier Vega-Ramos et al.   IMMUNOLOGY AND CELL BIOLOGY

The leukocyte activation antigen CD69 limits allergic asthma and skin contact hypersensitivity

(2010) Pilar Martín et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dynamic T cell migration program provides resident memory within intestinal epithelium

(2010) David Masopust et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Human Latency-Associated Peptide+ T Cells: A Novel Regulatory T Cell Subset

(2010) R. Gandhi et al.   JOURNAL OF IMMUNOLOGY

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence

(2010) L. M. Wakim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

The high-resolution structure of the extracellular domain of human CD69 using a novel polymer

(2009) Petr Kolenko et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Regulatory Lymphocytes and Intestinal Inflammation

(2009) Ana Izcue et al.   Annual Review of Immunology

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

(2009) S. Brand   GUT

Professional Memory CD4+ T Lymphocytes Preferentially Reside and Rest in the Bone Marrow

(2009) Koji Tokoyoda et al.   IMMUNITY

A Central Role for Induced Regulatory T Cells in Tolerance Induction in Experimental Colitis

(2009) D. Haribhai et al.   JOURNAL OF IMMUNOLOGY

CD69 Controls the Pathogenesis of Allergic Airway Inflammation

(2009) T. Miki-Hosokawa et al.   JOURNAL OF IMMUNOLOGY

A helpers' guide to infection

(2009) Thomas Gebhardt et al.   NATURE

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

(2009) Masako Murai et al.   NATURE IMMUNOLOGY

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade

(2008) Dmitry V. Ostanin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

The critical contribution of TGF-β to the induction of Foxp3 expression and regulatory T cell function

(2008) Ethan M. Shevach et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Smad7 Controls Resistance of Colitogenic T Cells to Regulatory T Cell-Mediated Suppression

(2008) Massimo C. Fantini et al.   GASTROENTEROLOGY

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

(2008) Andre Franke et al.   NATURE GENETICS

Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells

(2008) Irina L Grigorova et al.   NATURE IMMUNOLOGY

Moving targets: cell migration inhibitors as new anti-inflammatory therapies

(2008) Charles R Mackay   NATURE IMMUNOLOGY

Homing imprinting and immunomodulation in the gut: Role of dendritic cells and retinoids

(2007) Rodrigo J. Mora   INFLAMMATORY BOWEL DISEASES