Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging

T-cell Immunoglobulin and ITIM Domain Contributes to CD8+ T-cell Immunosenescence

(2018) Yangzi Song et al.   AGING CELL

Intestinal Barrier Impairment and Immune Activation in HIV-Infected Advanced Late Presenters are Not Dependent on CD4 Recovery

(2018) Kamila Wójcik-Cichy et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Early Reconstitution of NK and γδ T Cells and Its Implication for the Design of Post-Transplant Immunotherapy

(2018) Moniek A. de Witte et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Increased Soluble CD137 Levels and CD4+ T-Cell-Associated Expression of CD137 in Acute Atherothrombotic Stroke

(2018) Yang He et al.   CTS-Clinical and Translational Science

HIV and Age Do Not Synergistically Affect Age-Related T-Cell Markers

(2018) Shelli Farhadian et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection

(2018) Carly A. Dillen et al.   JOURNAL OF CLINICAL INVESTIGATION

Clonal CD4+ T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation

(2018) Lillian B. Cohn et al.   NATURE MEDICINE

Microbial translocation

(2018) Alexandra M. Ortiz et al.   Current Opinion in HIV and AIDS

Working in “NK Mode”: Natural Killer Group 2 Member D and Natural Cytotoxicity Receptors in Stress-Surveillance by γδ T Cells

(2018) Bruno Silva-Santos et al.   Frontiers in Immunology

Exhaustion of the CD8+ T Cell Compartment in Patients with Mutations in Phosphoinositide 3-Kinase Delta

(2018) Marjolein W. J. Wentink et al.   Frontiers in Immunology

HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction

(2018) Hisashi Akiyama et al.   Nature Communications

Exposure to Plasmodium vivax is associated with the increased expression of exhaustion markers on γδ T lymphocytes

(2018) Dimpu Gogoi et al.   PARASITE IMMUNOLOGY

Inflammation Related Morbidity and Mortality Among HIV-Positive Adults

(2017) Brian B. Hart et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Adoptive Transfer of Phosphoantigen-Specific γδ T Cell Subset AttenuatesMycobacterium tuberculosisInfection in Nonhuman Primates

(2017) Arwa Qaqish et al.   JOURNAL OF IMMUNOLOGY

Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy

(2017) Melissa E. Schechter et al.   Science Translational Medicine

Distinctive features of tumor-infiltrating γδ T lymphocytes in human colorectal cancer

(2017) S. Meraviglia et al.   OncoImmunology

Characterization of age-associated exhausted CD8+T cells defined by increased expression of Tim-3 and PD-1

(2016) Kyoo-A Lee et al.   AGING CELL

Ageing and inflammation in patients with HIV infection

(2016) M. Nasi et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

HIV Infection, Immunosuppression, and Age at Diagnosis of Non-AIDS-Defining Cancers

(2016) Meredith S. Shiels et al.   CLINICAL INFECTIOUS DISEASES

OMIP-037: 16-color panel to measure inhibitory receptor signatures from multiple human immune cell subsets

(2016) Anna C. Belkina et al.   CYTOMETRY PART A

Do Biomarkers of Inflammation, Monocyte Activation, and Altered Coagulation Explain Excess Mortality Between HIV Infected and Uninfected People?

(2016) Kaku A. So-Armah et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Narrowing the Gap in Life Expectancy Between HIV-Infected and HIV-Uninfected Individuals With Access to Care

(2016) Julia L. Marcus et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection

(2016) Glen M. Chew et al.   PLoS Pathogens

CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART

(2016) Rémi Fromentin et al.   PLoS Pathogens

Cutting Edge: PD-1 Regulates Imiquimod-Induced Psoriasiform Dermatitis through Inhibition of IL-17A Expression by Innate γδ-Low T Cells

(2015) Yasutomo Imai et al.   JOURNAL OF IMMUNOLOGY

Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1–Infected Men

(2015) Eileen Scully et al.   JOURNAL OF INFECTIOUS DISEASES

Plasma d-Dimer and Incident Ischemic Stroke and Coronary Heart Disease

(2015) Aaron R. Folsom et al.   STROKE

Prospective study of plasma D-dimer and incident venous thromboembolism: The Atherosclerosis Risk in Communities (ARIC) Study

(2015) Aaron R. Folsom et al.   THROMBOSIS RESEARCH

Peripheral Vγ9Vδ2 T Cells Are a Novel Reservoir of Latent HIV Infection

(2015) Natalia Soriano-Sarabia et al.   PLoS Pathogens

Inhibitory Receptors Beyond T Cell Exhaustion

(2015) Silvia A. Fuertes Marraco et al.   Frontiers in Immunology

Cross-sectional Comparison of the Prevalence of Age-Associated Comorbidities and Their Risk Factors Between HIV-Infected and Uninfected Individuals: The AGEhIV Cohort Study

(2014) J. Schouten et al.   CLINICAL INFECTIOUS DISEASES

Comparison of Risk and Age at Diagnosis of Myocardial Infarction, End-Stage Renal Disease, and Non-AIDS-Defining Cancer in HIV-Infected Versus Uninfected Adults

(2014) Keri N. Althoff et al.   CLINICAL INFECTIOUS DISEASES

Monocyte-Activation Phenotypes Are Associated With Biomarkers of Inflammation and Coagulation in Chronic HIV Infection

(2014) Eleanor M. P. Wilson et al.   JOURNAL OF INFECTIOUS DISEASES

Soluble Markers of Inflammation and Coagulation but Not T-Cell Activation Predict Non–AIDS-Defining Morbid Events During Suppressive Antiretroviral Treatment

(2014) Allan R. Tenorio et al.   JOURNAL OF INFECTIOUS DISEASES

Elevated Levels of Monocyte Activation Markers Are Associated With Subclinical Atherosclerosis in Men With and Those Without HIV Infection

(2014) Rebeccah A. McKibben et al.   JOURNAL OF INFECTIOUS DISEASES

Automated identification of stratifying signatures in cellular subpopulations

(2014) Robert V. Bruggner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma fibrinogen associates independently with total and cardiovascular mortality among subjects with normal and reduced kidney function in the general population

(2014) A. G. Stack et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality

(2014) Sergio Serrano-Villar et al.   PLoS Pathogens

Severity of Cardiovascular Disease Outcomes Among Patients With HIV Is Related to Markers of Inflammation and Coagulation

(2014) Anna D. Nordell et al.   Journal of the American Heart Association

HIV-1 infection induces strong production of IP-10 through TLR7/9-dependent pathways

(2013) Rachel P. Simmons et al.   AIDS

Co-Morbidities in Persons Infected with HIV: Increased Burden with Older Age and Negative Effects on Health-Related Quality of Life

(2013) Alan T. Rodriguez-Penney et al.   AIDS PATIENT CARE AND STDS

Cause-Specific Life Expectancies After 35 Years of Age for Human Immunodeficiency Syndrome-Infected and Human Immunodeficiency Syndrome-Negative Individuals Followed Simultaneously in Long-term Cohort Studies, 1984–2008

(2013) Nikolas Wada et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Specific Recruitment of    Regulatory T Cells in Human Breast Cancer

(2013) J. Ye et al.   CANCER RESEARCH

Invariant natural killer T (iNKT) cell exhaustion in sarcoidosis

(2013) Jennifer E. Snyder-Cappione et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-Derived    Regulatory T Cells Suppress Innate and Adaptive Immunity through the Induction of Immunosenescence

(2013) J. Ye et al.   JOURNAL OF IMMUNOLOGY

The Frequency of CD127+ Hepatitis C Virus (HCV)-Specific T Cells but Not the Expression of Exhaustion Markers Predicts the Outcome of Acute HCV Infection

(2013) E.-C. Shin et al.   JOURNAL OF VIROLOGY

Immune activation and HIV persistence

(2013) Hiroyu Hatano   Current Opinion in HIV and AIDS

PD-1 Dependent Exhaustion of CD8+ T Cells Drives Chronic Malaria

(2013) Joshua M. Horne-Debets et al.   Cell Reports

Defective CD8 T Cell Responses in Aged Mice Are Due to Quantitative and Qualitative Changes in Virus-Specific Precursors

(2012) V. Decman et al.   JOURNAL OF IMMUNOLOGY

Inflammation, Coagulation and Cardiovascular Disease in HIV-Infected Individuals

(2012) Daniel A. Duprez et al.   PLoS One

Characterization of Human γδ T Lymphocytes Infiltrating Primary Malignant Melanomas

(2012) Adriana Cordova et al.   PLoS One

Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering

(2012) K. F. Stengel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD160 and PD-1 Co-Expression on HIV-Specific CD8 T Cells Defines a Subset with Advanced Dysfunction

(2012) Yoav Peretz et al.   PLoS Pathogens

Premature Aging and Premature Age-Related Comorbidities in HIV-Infected Patients: Facts and Hypotheses

(2011) J. Capeau   CLINICAL INFECTIOUS DISEASES

Morbidity and Aging in HIV-Infected Persons: The Swiss HIV Cohort Study

(2011) B. Hasse et al.   CLINICAL INFECTIOUS DISEASES

Premature Age-Related Comorbidities Among HIV-Infected Persons Compared With the General Population

(2011) G. Guaraldi et al.   CLINICAL INFECTIOUS DISEASES

CD160: A unique activating NK cell receptor

(2011) Philippe Le Bouteiller et al.   IMMUNOLOGY LETTERS

Cutting Edge: TIGIT Has T Cell-Intrinsic Inhibitory Functions

(2011) N. Joller et al.   JOURNAL OF IMMUNOLOGY

Valganciclovir Reduces T Cell Activation in HIV-Infected Individuals With Incomplete CD4+ T Cell Recovery on Antiretroviral Therapy

(2011) Peter W. Hunt et al.   JOURNAL OF INFECTIOUS DISEASES

Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection

(2011) Netanya G. Sandler et al.   JOURNAL OF INFECTIOUS DISEASES

Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE

(2011) Peng Qiu et al.   NATURE BIOTECHNOLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

In Vivo Systems Analysis Identifies Spatial and Temporal Aspects of the Modulation of TNF- -Induced Apoptosis and Proliferation by MAPKs

(2011) K. S. Lau et al.   Science Signaling

T lymphocyte surface expression of exhaustion markers as biomarkers of the efficacy of chemotherapy for tuberculosis

(2011) Marcela Henao-Tamayo et al.   TUBERCULOSIS

Traditional risk factors and D-dimer predict incident cardiovascular disease events in chronic HIV infection

(2010) Emily S Ford et al.   AIDS

A subset of γδ lymphocytes is increased during HIV-1 infection

(2010) P. PAOLI et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Analysis of γδ region usage in normal and diseased human intestinal biopsies and peripheral blood by polymerase chain reaction (PCR) and flow cytometry

(2010) A. BUCHT et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Inflammation and Mortality in HIV-Infected Adults: Analysis of the FRAM Study Cohort

(2010) Phyllis C Tien et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

(2010) H.-T. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Associations of factor VIIIc, D-dimer, and plasmin-antiplasmin with incident cardiovascular disease and all-cause mortality

(2009) Aaron R. Folsom et al.   AMERICAN JOURNAL OF HEMATOLOGY

Enhanced levels of soluble and membrane-bound CD137 levels in patients with acute coronary syndromes

(2009) Liu Dongming et al.   CLINICA CHIMICA ACTA

Age-associated up-regulation of a negative co-stimulatory receptor PD-1 in mouse CD4+ T cells

(2009) Yukiko Shimada et al.   EXPERIMENTAL GERONTOLOGY

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

(2009) Bruno Martin et al.   IMMUNITY

Association of C-Reactive Protein and HIV Infection With Acute Myocardial Infarction

(2009) Virginia A Triant et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Phosphoantigen‐Expanded Human γδ T Cells Display Potent Cytotoxicity against Monocyte‐Derived Macrophages Infected with Human and Avian Influenza Viruses

(2009) Gang Qin et al.   JOURNAL OF INFECTIOUS DISEASES

Advancing age leads to predominance of inhibitory receptor expressing CD4 T cells☆

(2009) Rudragouda Channappanavar et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity

(2009) N. Stanietsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging and Infectious Diseases: Workshop on HIV Infection and Aging: What Is Known and Future Research Directions

(2008) Rita B. Effros et al.   CLINICAL INFECTIOUS DISEASES

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

(2008) R. Brad Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies

(2008)   LANCET

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

(2008) Xin Yu et al.   NATURE IMMUNOLOGY

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Long-Term Interleukin-6 Levels and Subsequent Risk of Coronary Heart Disease: Two New Prospective Studies and a Systematic Review

(2008) John Danesh et al.   PLOS MEDICINE

Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection

(2008) Lewis H Kuller et al.   PLOS MEDICINE