Article
Biology
Kristen Kurtzeborn, Hyuk Nam Kwon, Vladislav Iaroshenko, Imrul Faisal, Martin Ambroz, Xing Jin, Talha Qureshi, Jussi Kupari, Anneliis Ihermann-Hella, Juho Vaananen, Henna Tyynismaa, Iva Bousova, Sunghyouk Park, Satu Kuure
Summary: Through RNA sequencing and tissue-specific MAPK/ERK inactivation experiments, we found that MAPK/ERK signaling maintains ureteric bud tip cells, potentially playing a regulatory role in collecting duct progenitors. Additionally, we provide new mechanistic insights on how MAPK/ERK signaling regulates progenitor maintenance through its effects on chromatin accessibility and energy metabolism.
Article
Neurosciences
Haritha Kunhiraman, Leon McSwain, Shubin W. Shahab, Timothy R. Gershon, Tobey J. MacDonald, Anna Marie Kenney
Summary: This study found that the Sonic Hedgehog (SHH) subtype of medulloblastoma (MB) has a unique tumor microenvironment compared to other subtypes. The SHH MB cells were found to produce elevated levels of IGFBP2, which is required for SHH MB cell proliferation, colony formation, and cell migration. These findings suggest that targeting the IGFBP2-STAT3 axis could be a novel therapeutic approach for SHH medulloblastoma.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Cell Biology
Ewelina Trela, Qiang Lan, Satu-Marja Myllymaki, Clementine Villeneuve, Riitta Lindstrom, Vinod Kumar, Sara A. Wickstrom, Marja L. Mikkola
Summary: The early growth of the mammary rudiment is primarily accomplished by migration-driven cell influx, with minor contributions of cell hypertrophy and proliferation. Additionally, an invagination mechanism of the mammary bud is driven by thin, elongated keratinocytes-ring cells forming a contractile rim, likely exerting force via the actomyosin network. Additionally, conditional deletion of nonmuscle myosin IIA impairs invagination, resulting in abnormal mammary bud shape.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jin Hee Kim, In Gyoung Ju, Namkwon Kim, Eugene Huh, So-Ri Son, Joon Pyo Hong, Yujin Choi, Dae Sik Jang, Myung Sook Oh
Summary: This study aimed to investigate the anti-neuroinflammatory effects of yomogin, isolated from Artemisia iwayomogi. The results showed that yomogin suppressed neuroinflammatory factors and regulated the MAPK pathway, suggesting its potential as a therapeutic candidate for inflammation-mediated neurological diseases.
Article
Agriculture, Multidisciplinary
Junxing Jiang, Jitao Hai, Weiyi Liu, Yan Luo, Keqi Chen, Yirong Xin, Junping Pan, Yang Hu, Qin Gao, Fei Xiao, Huanmin Luo
Summary: Gallic acid can promote the differentiation and proliferation of neural stem cells by activating the MAPK/ERK pathway, while 3,4-dihydroxybenzoic acid is the main active structure with neurotrophic activity. The introduction of different groups may lead to different effects on neural stem cells.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Plant Sciences
Hui Xiong, Miao Luo, Yankun Ju, Zhongqiu Zhao, Man Zhang, Ran Xu, Yongshen Ren, Guangzhong Yang, Zhinan Mei
Summary: The triterpene saponins from Entada phaseoloides have been found to have therapeutic effects on collagen-induced arthritis in rats, reducing symptoms, decreasing the production of inflammatory cytokines, and inhibiting the MAPK signaling pathway, which ultimately prevents the progression of rheumatoid arthritis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Natalia A. Muraleva, Nataliya G. Kolosova, Natalia A. Stefanova
Summary: SkQ1 alleviates AD pathology by suppressing MEK1/2-ERK1/2 signaling pathway activity in the OXYS rat hippocampus, making it a promising candidate drug for human AD treatment.
Article
Oncology
Xitao Zhang, Tianlai Liu, Jinlin Huang, Jianping He
Summary: This study revealed that PICALM promotes CRC progression through the ERK/MAPK signaling pathway, highlighting its potential as a therapeutic target in clinical applications.
CANCER CELL INTERNATIONAL
(2022)
Article
Biology
Mamoru Ishii, Tomoko Tateya, Michiyuki Matsuda, Tsuyoshi Hirashima
Summary: This study explores how the activation waves of extracellular signal-regulated kinase (ERK) control collective cell migration during murine cochlear duct development, promoting duct elongation and development. Through deep tissue live-cell imaging and mathematical modeling, they reveal how the multicellular flow occurring on the lateral side is influenced by the propagating ERK activation.
Article
Cell Biology
Hanlin Ma, Gonghua Qi, Fang Han, Panpan Gai, Jiali Peng, Beihua Kong
Summary: HMGB3 promotes the proliferation and metastasis of ovarian cancer through the MAPK/ERK signaling pathway. Targeting HMGB3 is a promising strategy for the treatment of ovarian cancer and can improve the prognosis of patients.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Multidisciplinary Sciences
Alan D. Stern, Gregory R. Smith, Luis C. Santos, Deepraj Sarmah, Xiang Zhang, Xiaoming Lu, Federico Iuricich, Gaurav Pandey, Ravi Iyengar, Marc R. Birtwistle
Summary: We investigated the single-cell dynamics of ERK and Akt pathways and their correlation with cell division events in non-transformed MCF10A epithelial cells. We found that both ERK and Akt activities were significantly higher during the S-G2 phase of cell division. ERK activity was more strongly associated with division fates compared to Akt activity, suggesting a greater role for ERK in driving cell division in this context.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Kyung Min Chung, Hyunha Kim, Claudio Gouveia Roque, Ethan P. McCurdy, Trang T. T. Nguyen, Markus D. Siegelin, Jee-Yeon Huang, Ulrich Hengst
Summary: This study reveals a mechanism in which cells secrete a factor, TAILS, to enhance antioxidant signaling and mitochondrial function in neighboring neurons, providing protection against oxidative stress. This mechanism plays a critical role in preserving cognitive function in ischemic brain injury.
Article
Cell Biology
Jia-Yun Chen, Clemens Hug, Jose Reyes, Chengzhe Tian, Luca Gerosa, Fabian Frohlich, Bas Ponsioen, Hugo J. G. Snippert, Sabrina L. Spencer, Ashwini Jambhekar, Peter K. Sorger, Galit Lahav
Summary: Oncogene-induced senescence is a phenomenon where abnormal oncogene expression leads to non-proliferative state in non-transformed cells. The heterogeneity in cellular response during oncogenic induction remains unclear. However, our study on human epithelial cells revealed that a narrow range of BRAFV600E expression resulted in a wide range of downstream ERK activities, which displayed a non-monotonic relationship with proliferation. We identified four distinct ERK response classes that together contribute to ERK-proliferation response and generation of heterogeneity.
Article
Biochemistry & Molecular Biology
Ana Dunatov Huljev, Nela Kelam, Benjamin Benzon, Violeta Soljic, Natalija Filipovic, Valdi Pesutic Pisac, Merica Glavina Durdov, Katarina Vukojevic
Summary: Clear cell renal cell carcinoma (ccRCC) is the deadliest neoplasm of the urinary tract. The expression of Sonic Hedgehog (SHH) was found to be higher in grade 1 tumors and decreased with tumor progression. PTCH expression was lower in grades 1 and 2 compared to the control and grade 4, while SMO expression was higher in grade 4 than in other grades and the control. High PTCH and low SMO expression were associated with better survival rates in ccRCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Hongxv Wang, Danyu Du, Jianwen Huang, Shuai Wang, Xv He, Shengtao Yuan, Jing Xiao
Summary: This study reveals the role of GPR27 in hepatocellular carcinoma (HCC) progression. The results demonstrate that downregulation of GPR27 inhibits cell proliferation and colony formation, while overexpression of GPR27 has the opposite effect. Furthermore, GPR27 expression affects the activation of the MAPK/ERK signaling pathway in HCC cells, thereby modulating cell proliferation.
CANCER MANAGEMENT AND RESEARCH
(2022)