Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway

Hepatitis B virus X protein stimulates the Hedgehog–Gli activation through protein stabilization and nuclear localization of Gli1 in liver cancer cells

(2011) Hye Young Kim et al.   CANCER LETTERS

Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer

(2011) Hideya Onishi et al.   CANCER SCIENCE

Epithelial mesenchymal transition and hedgehog signaling activation are associated with chemoresistance and invasion of hepatoma subpopulations

(2011) Xiaoli Chen et al.   JOURNAL OF HEPATOLOGY

miR-338-3p suppresses invasion of liver cancer cell by targeting smoothened

(2011) Xiao-Hui Huang et al.   JOURNAL OF PATHOLOGY

Hedgehog Signaling Antagonist Promotes Regression of Both Liver Fibrosis and Hepatocellular Carcinoma in a Murine Model of Primary Liver Cancer

(2011) George M. Philips et al.   PLoS One

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

The Role of the Hedgehog Signaling Pathway in the Development of Basal Cell Carcinoma and Opportunities for Treatment

(2010) I. Caro et al.   CLINICAL CANCER RESEARCH

Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis

(2010) Nuria Martínez-López et al.   HEPATOLOGY

Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling

(2010) Hong Chang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sonic Hedgehog/GLI1 signaling pathway inhibition restricts cell migration and invasion in human gliomas

(2010) Ke Wang et al.   NEUROLOGICAL RESEARCH

The role of signaling pathways in the development and treatment of hepatocellular carcinoma

(2010) S Whittaker et al.   ONCOGENE

Mitogen-activated protein kinases in hepatocellular carcinoma development

(2010) Lihua Min et al.   SEMINARS IN CANCER BIOLOGY

Expression of the glioma-associated oncogene homolog (GLI) 1in human breast cancer is associated with unfavourable overall survival

(2009) Anette ten Haaf et al.   BMC CANCER

Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer

(2009) Fu-Guo Xu et al.   CANCER LETTERS

Epidermal Growth Factor Receptor Signaling Synergizes with Hedgehog/GLI in Oncogenic Transformation via Activation of the MEK/ERK/JUN Pathway

(2009) Harald Schnidar et al.   CANCER RESEARCH

Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9

(2009) Jing-song Chen et al.   HEPATOLOGY RESEARCH

Sonic hedgehog relates to colorectal carcinogenesis

(2009) Kozo Yoshikawa et al.   JOURNAL OF GASTROENTEROLOGY

Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells

(2009) Wei Wei et al.   Molecular Cancer

Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer

(2009) Motoko Seto et al.   MOLECULAR CARCINOGENESIS

Down-Regulation of Hedgehog-Interacting Protein through Genetic and Epigenetic Alterations in Human Hepatocellular Carcinoma

(2008) M. Tada et al.   CLINICAL CANCER RESEARCH

Hepatocellular carcinoma: latest developments

(2008) Natasha Walzer et al.   CURRENT OPINION IN GASTROENTEROLOGY

Blocking the hedgehog pathway inhibits hepatoblastoma growth

(2008) Melanie Eichenmüller et al.   HEPATOLOGY

Molecular mechanisms of hepatocellular carcinoma

(2008) Rajagopal N. Aravalli et al.   HEPATOLOGY

Extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinases (MMPs) as regulators of tumor–host interaction in a spontaneous metastasis model in rats

(2008) Ana Carolina Donadio et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Gli2 upregulates cFlip and renders basal cell carcinoma cells resistant to death ligand-mediated apoptosis

(2008) E Kump et al.   ONCOGENE

Src kinase regulates metalloproteinase-9 secretion induced by type IV collagen in MCF-7 human breast cancer cells

(2007) P CORTESREYNOSA et al.   MATRIX BIOLOGY